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      • 염화 제 2철의 적합치가 유도하는 쥐의 경동맥 혈전증 모델 : 은행 나무 추출물의 효과

        진복희 대한임상검사과학회 2011 대한임상검사과학회지(KJCLS) Vol.43 No.4

        Obstructive sleep apnea (OSA) is the most common type of sleep apnea and is caused by obstruction of the upper airway. Since it is closely related to sleep parameter and body indices, the study was focused on the relationship with them. The results of polysomnography (PSG) in obstructive sleep apnea was done at ENT department of Ewha women university Mokdong hospital from March to September 2010 with 52 subjects (male 35, female 17). The leads were placed to measure electroencephalogram (EEG), electrooculogram (EOG), mandibular and anterior tibialis electromyogram (EMG), airflow in nasal and oral cavity, chest and abdominal breathing pattern, snoring sound and arterial oxygen saturation (SpO2) level. From sleep parameter and body indices of adult obstructive sleep apnea compared to normal adult revealed that age (p<0.01) and snoring sound (p<0.05) were increased, stage 1 sleep (p<0.01) was increased, the deeper stages (3&4) of sleep (p<0.05) were reduced. Respiratory disturbance index (RDI) (p<0.01), mean SpO2 (p<0.05) and lowest SpO2 (p<0.01) were also decreased. The correlation analysis from sleep parameter and body indices of OSA showed the positive correlation with age (r=0.463, p<0.001), snoring sound (r=0.278, p<0.05), stage 1 sleep (r=0.391, p<0.01) and RDI (r=0.409, p<0.01), but showed the negative correlation with the deeper stages (3&4) of sleep (r=-0.307, p<0.05), mean SpO2=(r=-0.274, p<0.05) and lowest SpO2 (r=-0.392, p<0.01). This study proves that obstructive sleep apnea and indices have closed related. .

      • KCI등재후보

        뇌졸중 환자의 동맥경직도에 따른 임상검사결과와 유병률의 비교

        진복희,한민호 대한임상검사과학회 2014 대한임상검사과학회지(KJCLS) Vol.46 No.4

        Pulse wave velocity (PWV) is used to non-invasively estimate the severity of arteriosclerosis by measuring the patient's arterial stiffness comparing with each normal reference range according to their ages. Increased arterial stiffness is closely related to both atherosclerosis and arteriosclerosis, which have been known for causes of cardiovascular disease and stroke, also negatively affects the prognosis and the re-occurrence in patients with stroke. The study is focused on how brachial-ankle pulse wave velocity (baPWV) is related to cardiovascular disease risk factors in patients with acute stroke. There were 114 subjects, 69 males and 45 females, all in their 60's and had PWV test for acute stroke. The results are as follows: the group with increased arterial stiffness showed significant increase in HbAlc, total cholesterol, RSBP (resting systolic blood pressure), CSBP (central systolic blood pressure) and CDBP (central diastolic blood pressure). Cross tabulation test showed that there was a significant relationship only between the group with increased arterial stiffness and diabetes mellitus (DM). Therefore, it might be useful for preventing re-occurrence and making a favorable prognosis to promptly adjust DM and hypertension-related risk factors in patients with acute stroke.

      • Apnea-Hypopnea 지수에 따른 수면 매개 변수의 비교

        진복희 대한임상검사과학회 2012 대한임상검사과학회지(KJCLS) Vol.44 No.4

        Obstructive sleep apnea (OSA) is the most common type of sleep apnea and is caused by obstruction of the upper airway. It is characterized by repetitive pauses in breathing during sleep despite the effort to breathe. Apnea is closely related to clinical findings and respiratory disturbance index (RDI). The total subjects were 42 (male 26, female 16) and examined by polysomography (PSG) in terms of RDI above 5 and below 5 at Mok-Dong Hospital in Ewha Womans University from January to June, 2012. The study revealed the followings: The comparison of clinical findings and RDI above 5 showed significant increase in age, BMI, and snoring sound although lowest SpO2 level decreased. The correlation coefficient analysis between clinical findings and RDI showed statistically significant correlation in age, BMI, lowest SpO2 although snoring sound and average SpO2 showed statistically insignificant correlation. .

      • KCI등재

        혈청 총 콜레스테롤과 혈압, 비만 및 일상 생활습관의 관련성에 관한 연구

        진복희,김주영 대한보건협회 1995 대한보건연구 Vol.21 No.2

        고혈압과 동맥경화성 지질의 상승은 매우 높은 관련성을 갖고 있으나, 그 상관성에 대한 역학조사에서는 일치된 결과를 보여주지 못하고 있다. 고혈압과 혈청 지질의 관계를 명확히 규명하는 것은 고혈압이 어떻게 관상동맥 질환의 위험요인으로 작용하고 있는지에 대한 기전을 밝히는데 중요한 정보를 제공할 수 있다. 본 연구는 30-69세의 직장 성인 남자 5,011명(평균연령 50.5±9.9)과 여자 1,171명(평균연령 577±9.0)을 대상으로 혈청 총 콜레스테롤과 혈압 및 기타 신체지수와의 관련성을 조사하였다. 혈청 총 콜레스테롤과 혈압, 체중 등은 공복시에 측정하였으며, 가족력, 음주 및 흡연습관은 설문지를 통하여 조사하였다. 수축기 혈압의 평균은 남자 120.7±14.7 mmHg, 여자 111.2±12.2 mmHg, 이완기 혈압의 평균은 남자 77.5士10.l mmHg, 여자 71.5±9.5 mmHg였으며, 혈청 총 콜레스테롤은 남자 190.9±38.9 mg/dL, 여자 183.9±39.4 mg/dL였다. PIBW는 남자 107.7±13.0%, 여자 102.6±12.7%였으며, BMI는 남자 23.6±26 ㎏/㎡ 여자 21.4±2.9 ㎏/㎡였다. 수축기 혈압과 이완기 혈압은 남녀 모두 연령이 증가함에 따라 증가하였으나, 총 콜레스테롤, PIBW 및 BMI는 남녀 모두 연령이 증가함에 따라 감소하였다. 총 콜레스테롤은 혈압이 높아짐에 따라 남녀 모두 증가하였으며, 특히 PIBW가 증가함에 따라 매우 유의하게 증가하였다. 남자의 수축기 및 이완기 혈압은 PIBW가 증가함에 따라 매우 유의하게 증가하였으며, 여자는 약간 증가하였다. PIBW와 BNI의 증가에 따른 총 콜레스테롤의 증가가 혈압에 따른 총 콜레스테롤의 증가 보다 매우 유의하게 더 컸다. 가족력은 총 콜레스테롤 및 혈압에 미치는 영향이 적었으며, 음주량은 혈압과 양(positive)의 상관성이 있었으나, 흡연량은 음(negative)의 상관성이 있었다. 위의 결과는 혈청 총 콜레스테롤이 특히 혈압 및 비만과 밀접한 상호 관련성이 있음을 보여주었다. High blood pressure has been associated with elevated atherogenic blood lipid fraction, but epidemiological surveys often give inconsistent results across population subgroups. A better understanding of relation between blood pressure and blood lipids may provide insight into the mechanism whereby hypertension is associated with increased risk of coronary heart disease. We assessed the cross-sectional relations of serum total cholesterol with other health parameters in a population of 5,011 men and 1,171 women 30-69 years old. Measurements of percent ideal body weight (PIBW), body mass index (BMI), blood pressure and cholesterol were made and a questionnaire on family history, smoking, drinking habit was given to each adult subjects. The mean systolic and diastolic blood pressure were 119.0±14.8 mmHg and 76.4±10.2 mmHg, respectively. The mean serum total cholesterol level was 190.9±38.9 mg/dL in men, 183.9±39.4 mg/dL in women, respectively. The systolic and diastolic blood pressure levels increased with age in both sexes, but the levels of serum total cholesterol, PIBW and BMI decreased with age in both sexes. Total cholesterol levels increased significantly with increasing systolic and diastolic blood pressure in both sexes. Total cholesterol levels increased very significantly with increasing PIBW index in both sexes. In men, systolic & diastolic blood pressure levels were very significantly increased with increasing PDBW index, but in women, its increased slightly. The PIBW and BMI index had more influence on the total cholesterol level than blood pressure. Family history had little influence on the cholesterol and blood pressure. Alcohol consumption correlated positively with blood pressure, but cigaretting smoking correlated negatively with blood pressure. These results support the hypothesis that there are biological interrelations between blood pressure and blood lipids that may influence the mechanisms whereby blood pressure is associated with risk of coronary heart disease.

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