폐의 암육종 1예

허방,황적준,허만하 대한병리학회 1986 Journal of Pathology and Translational Medicine Vol.20 No.2

실험적 간섬유화 병변의 미세혈관계 변화에 관한 주사 전자현미경적 연구

허방,이명종,천봉권,신동훈,이충한 고신대학교 의학부 2004 高神大學校 醫學部 論文集 Vol.19 No.1

Background: The lover parenchymal cells are supported by delicate sinusoidal vessels and portal tract connective tissue. Hepatic fibrosis cause disorganization of these supporting structures, which lead to abnormal microcirculation. Material & methods: Morphological changes of hepatic microvasculature were examined bu scanning electron microscopy (SEM) in N-diethylnitrosamine (DEN)-induced experimental hepatic fibrosis of rat. Experimental animal livers were perfused with warm saline and fixed with mixture of 0.5% glutaradehyde and 0.5% paraformaldehyde. And then, methacrylate resin (Mercox CL-2R) was injected through the hepatic artery. Vascular casts were prepared with 20% NaOH maceration. Results: Hepatic fibrosis with nodular regeneration was seen after 9 week DEN treatment. Microvasculature of DEN-induced liver tissues showed marked distortion and dilatation of major branches of hepatic arteries and portal veins. These changes were initially noticed in 6 week DEN-treated group. Abnormal connection between increased peribiliary plexus (PBP) and branches of hepatic artery and portal veins, and between PBP and sinusoidal vasculature were frequently observed around regenerating nodules. Conclustions: These findings suggest that development of abnomal microvasculature, especially in PBP and arteriolo-portal anastomosis, in experimental hepatic fibrosis may potentiate the hepatic fibrosis and play a role micro-collateral circulation in portal hypertension of liver cirrhosis.

과립성 에나멜아세포종 1례 : A Case Report

허방,김혜숙,장희경,허만하 고신대학교 의학부 1988 高神大學校 醫學部 論文集 Vol.4 No.1

An ameloblastoma is a rare odontogenic tumor, in which several morphologic types have been described. Among these types, granular cell ameloblastoma is most uncommon in occurance and ocntroversial in histogenesis of granular cell and its nature. The authors experienced a rare case of pathologically confirmed granular cell ameloblastoma of mandible in 45-year-old Korean female. We report this case with literature review emphasizing the histogenesis of granular cell and its granule of the granular cell ameloblastoma. To our knowledge, this is the second reported case of granular cell ameloblastoma of Jaw, in Korea.

늑막에 발생한 양성 한국성 섬유성 중피 세포종 : 병리발생을 고찰한 1예 A case report with a review on histogenesis

허방,허만하 高神大學 醫學部 1989 高神大學醫學部 論文集 Vol.5 No.1

과립성 에나멜아세포종 1례

허방,김혜숙,장희경,허만하 고신대학교(의대) 고신대학교 의과대학 학술지 1988 고신대학교 의과대학 학술지 Vol.4 No.1

An ameloblastoma is a rare odontogenic tumor, in which several morphologic types have been described. Among these types, granular cell ameloblastoma is most uncommon in occurance and ocntroversial in histogenesis of granular cell and its nature. The authors experienced a rare case of pathologically confirmed granular cell ameloblastoma of mandible in 45-year-old Korean female. We report this case with literature review emphasizing the histogenesis of granular cell and its granule of the granular cell ameloblastoma. To our knowledge, this is the second reported case of granular cell ameloblastoma of Jaw, in Korea.

N-DEN에 의한 백서의 간섬유화 병변의 동모양혈관의 미세 구조의 변화

허방,김경원,김영옥,윤명희,이충한 고신대학교 의학부 2004 高神大學校 醫學部 論文集 Vol.19 No.1

Background: Hepatic sinusoid is lined by specialized endothelial cells showing numerous tiny fenestrae, and is not supported by an intact basement membrane, which permit direct transportation of fluid and micromolecules between Disse space and sinusoidal vascular lumen. Material & Methods: The purpose of this study is to investigate the ultrastructural changes of hepatic sinusoid during experimentally induced hepatic fibrosis with 12 week N-diethylnitrosamine (DEN, 200 ppm) oral intake. The rat liver tissues were examined under the light microscope, transmission and scanning electron microscope. Results: Comparing with number of sieve plate(10±3) and number of fenestrae(42±15) per a sieve plate in control group, their numbers were reduced in all DEN-treated groups, which were significantly correlated with duration of DEN intake. And also noted were decreased size of fenestrae. Although discontinous basal lamina around the sinusoidal endothelium and deposition of amorphous material in Disse space were initially noted in 6 week DEN-treated group, intact basal lamina was observed in 12 week DEN-treated group. Ito cells showed decreased fat droplets and well developed RER after 6 week DEN treatment. Conclusions: These results suggest that ultrastructural changes of fenestrae in sinusoidal endothelial cells precede the deposition of extracellular matrix in Disse space, leading to development of basement membrane, and that Ito cells are participated in the capillarization process of hepatic sinusoid. It could be speculated that inhibition of Ito cell proliferation might delay the process of hepatic fibrosis in cirrhosis.

會計變更에 關한 考察

許昉 숭전대학교 1983 崇營論集 Vol.2 No.1

자궁 내막 선암종을 동반한 Stein-Leventhal 증후군 : 1증례 보고 A Case Report

허방,전인선,허만하 고신대학교 의학부 1990 高神大學校 醫學部 論文集 Vol.6 No.1

Stein-Leventhal first described a syndrome consisting of amenorrhea, infertility, and a pathologic feature of bilateral polycystic ovries This syndrome is not infrequently associated with endometrial hyperplasia or carcinoma Through a number of possible theories regarding etiologic factors have been explored, the pathogenetic mechanisms are including hypothalamus-pituitary axis, adrenal factors, and ovarian steroidogenesis. The authors present a case of Stein-Leventhal syndrome associated with endometrial adenocarcinoma in a 30-year-old female, who complained of intermittent vaginal bleeding for 10 years and infertility for 5 years of marriage. A diagnostic endometrial curettage showed grade I endometrial adenocarcinoma Total hysterectomy with bilateral salpingo-oophorectomy was performed. Both ovaries revealed symmetrical enlargement and disclosed multiple subcapsular cystic follicles. Numerous primodial follicles were noted. However, corpus luteum and albicans were not identified. The endometrial mucosal surface showed irregular mucosal elevation which was confirmed to be endometrial adenocarcinoma. We report this case in view of its rarity and academic interest along with a literature review on the pathogenesis.

자궁 내막 선암종을 동반한 Stein-Leventhal 증후군 - 1증례 보고 -

허방,전인선,허만하 고신대학교(의대) 고신대학교 의과대학 학술지 1990 고신대학교 의과대학 학술지 Vol.6 No.1

Stein-Leventhal first described a syndrome consisting of amenorrhea, infertility, and a pathologic feature of bilateral polycystic ovaries. This syndrome is not infrequently associated with endometrial hyperplasia or carcinoma. Through a number of possible theories regarding etiologic factors have been explored, the pathogenetic mechanisms are including hypothalamus-pituitary axis, adrenal factors, and ovarian steroidogenesis. The authors present a case of Stein-Leventhal syndrome associated with endometrial adenocarcinoma in a 30-year-old female, who complained of intermittent vaginal bleeding for 10 years and infertility for 5 years of marriage. A diagnostic endometrial curettage shwed grade 1 endometrial adenocarcinoma. Total hysterectomy with bilateral salpingo0oophorectomy was performed. Both ovaries revealed symmetrical enlargement and disclosed multiple subcapsular cystic follicles. Numerous primodial follicles were noted. However, corpus luteum and albicans were not identified. The endometrial mucosal surface showed irregular mucosal elevation which was confirmed to be endometrial adenocarcinoma. We report this case in view of its rarity and academic interest along with a literature review on the pathogenesis.

늑막에 발생한 양성 한국성 섬유성 중피세포증

허방,허만하 고신대학교(의대) 고신대학교 의과대학 학술지 1989 고신대학교 의과대학 학술지 Vol.5 No.1

Localized fibrous mesothelioma of pleura is a relatively uncommon tumor of which histogenesis of the tumor cells is still controversial. It remains uncertain whether this tumor takes origin from mesothelial cells or submesothelial connective tissue. Although some of tissue culture and electron microscopic studies reveal both epithelial and fibroblastic nature, others, employing immunohistochemical studies, fail to reveal an evidence of epithelial characteristics. The authors report a typical case of histologically benign form of localized fibrous mesothelioma of the night pleura in a 54-year-old Korean female along a brief review of some related literatures with a special reference on the histogenesis of the tumor cells. This is the second reported case of benign localized fibrous mesothelioma of pleura, followed by the report of Kwon etal(1984) in Korea.