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- 저자 : 曺方煥 (검색결과 18 건)
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과민성 대장염에 대한 Trimebutine(polybutine)의 임상적 효과
조방환,백정민 순천향대학교 1982 논문집 Vol.5 No.3
Thirty patients with functional disturbance of gastro-intestinal tract received polybutine orally for 2 Months. At the end of trial, the therapeutic effect of polybutine was as follows. 1) Female was higher than male in functional disturbance of gastro-intestinal tract. 2) 40∼50 years old in age was higher than other's age groups. 3) High incidence of Symptoms with abdominal pain, flatulence, anorexia, and diarrhea were complained. 4) Therapeutic effect with ???????, for 4 to 6 weeks. 5) Specific effect among the symptoms, especially nausea, vomiting, diarrhea, abdominal pain and constipation by ??????? administration, orally, approximately 88%.
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조방환 ( B. H. Cho ),( H. H. Woo ),( S. H. Lee ),( S. Y. Bae ),( H. S. Lee ) 대한내과학회 1968 대한내과학회지 Vol.11 No.5
It has been believed that there might be significant changes of bacterial endocarditis in incidence and in bacteriologic and clinical behabior since the advent of effective new antibiotic therapy. A significant aspect of the changing picture of this disease is an increasing involvement of agents such as fungi and even rickettsias; there fore, some authors prefer the term infective endocarditis to common designation bacterial endocarditis. We have observed 44 cases of bacterial endocarditis over the past 8 years since 1959. The diagnosis of bacterial endocarditis was made by autopsy studies when characteristic clinical features were obscure and blood cultures sterile. From clinical and laboratory examinations, following results were obtained. 1. The range of age was between 2 weeks and 69 years with the highest incidence in the 4th decade. 2. Positive blood culture in 28 out of 33 cases was established. 19 were caused by staphylococcus aureus, but 3 of the present group were infected by mixed organisms. Beta-hemolytic streptococcus albus in 2, streptococcus viridans in 2, and fungus in 2 cases. 3. Other uncommon organisms were cultured in the cases of staph albus, strept viridans or fungus endocarditis. Micro-organisms studied sensitivity to sufa drugs, penicillin, methicillin, streptomycin, chloramphenicol, tetracycline, erythromycin and furadantin, were sensitive to methicillin in all 23 cases. 4. Out of 44 cases, underlying heart diseases were observed in 14 cases, of which 6 were rheumatic valvular heart disease, 4 congenital heart disease, 3 arteriosclerotic heart disease and a syphylitic aortic insufficiency.
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月經週期에 따른 子宮 Protransglutaminase量의 變動 및 이에 미치는 Estrogen 및 Progesterone의 影響
曺方煥 순천향대학교 1980 논문집 Vol.3 No.1
Transglutaminase from its zymogen, protransglutaminases which have been observed in blood plasma, platelets, uterus and placenta, catalyzes the covalent intermolecular polymerization of fibrin, through formation of E(r-glutamy) lysine crosslink. However, little is known concerning the physiological role of the protransglutaminase of the uterus. There fore we made an attempt to observe the changes of the level of the protransglutaminase of the uterus during menstrual cycle and the effect of both estrogen and progesterone on the level of that zymogen. Fluorescent antibody technique was employed for Immunohistological observation. The results were as follows: 1. Protransglutaminase of the uterus appears to be located in the endometrial glandular epithelial cells. 2. The levels of the protransglutaminase of the uterus in orders are as follows, ie. e., proliferative phase, secretory phase and menstrual phase. 3. Estrogen increased the level of the uterine protransglutaminase, whereas progesterone decreased the level of it. 4. The synthesis of the uterine protransglutaminase appears to be dependent upon both estrogen and progesterone.
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曺方煥 순천향의과대학 1978 Journal of Soonchunhyang Medical Science Vol.1 No.1
Disturbances of gastric secretion as related to thyroidal gland dysfunction have heen noted for many years. In both old and recent literature one finds conflicting statements regarding the gastric contents in thyroidal diseases. King stated that in exophthalmic goitre there might be a complete cessation of hydrochoric acid resulting in practically achylia gastrica, and the good results were obtained by acid therapy and diet regulations were sometimes striking. Lookwood studied the gastric contents of 24 patients with hyperthyroidism who had gastrointestinal symptoms and found 10 or 41.1 persent showing no free hypdrochloric acid and 3 low acid. Keeper and Bloomfield mentioned 30 persent as the incidence of achlorhydria in hyperthyroidism. In a series of 21 cases more found achlorhydria in 76 persent. Lerman and Mean noted that 19 (38 persnet) of their 50 patients with thyrotoxicosis had achlorhydria, where as only 26(13 persent) of 200 normal persons had achlorhydria after histamine test. In contrast to a large number of erports on gastric secretion in thyrotoxicosis published before 1941, few observations have been made since. Very recently, some reports were published on the results of the augmented histamine test in patients with thyrotoxicosis. On the other hand Neilson considered hypoacidity as one of the early signs of hyperthyroidism. Lewit reported that thyroxin administration, either subcutaneously or by mouth, resulted in an increase in of the gastric acid secretion in the majority (69 percent) of 26 patients examined. Boenheim found no characteristic gastric secretion pattern in exophthalmic goitre. The same confusion exists in the reports on the gastric secretion in myxedema and hypothyroidism. Katz cited cases with low thyroid function and hyperacidity relieved by thyroid hormons. Levy also found hyperacidity in all but one of 10 cases of hypothyroidism. On the other hand, Boenheim observed achlorthdria in the 3 patients studied by him. In two of these, gastric acidity became normal after thyrcid medication. Lockwood reported on 10 cases of myxedema and found achlorhydria in 60 percent. A general criticism may be applied to all the results obtained by the above investigators, particularly those who dealt with the incidence of achlorhydria in thyroidal diseases namely, that the gastric juice was obtained by means of test meals and not histamine. Althouth it is now well recognized that free achlorhydria cannot be diagnosed with any certainty unless the gastric juice is obtained by means of a maximum stimulation as with histamine, our studies were carried out in an attempt to obtain the knowledge of the gastric acidity in some thyroidal diseases by means of the conventional test meals. A total of 45 patients with diffuse tixic goitre had gastric analyses done by the method described. Almost all the patients were in the age of 20 to 60, only two below 20 and one over 60 years of age. The majority of patients were under 40 years of age, There were 11 males and 34 females. The striking result is the high incidence of anacidity 40.0 persent for the proup. The incidence of anacidity in 129 normal Korean adult examined the same way by us was found to be 10.6 percent. The difference becomes all the more significant if the result of the same age group in the normal and thyrotoxic subject are compared. The result also shows that the incidence of hypoacidity is higher in the diffuse toxic goitre group than in the normal, whereas that of hyperacidity is much lower. The relationships between the acidity of the gastric juice, the metabolic rate and the thyroidal 131I-uptake were also analyzed. A probable inverse relationship exists between the metabolic rate and 131I uptake, and gastric acidity. The gastric acidity of 22 patoients with diffuse nontoxic goitre was the same as in the normal. Twenty eight patients with myxedema were studied. All but two of the patiens wer females, Here also the remarkable results are the relatively low acidity in the group as a whole and the high incidence of anacidity-26.9percent for the group. The acidity of myxedema has also been correlated with various factors such as age, B.M.R., and thyroidal 131I uptake. This group also indicated a probable relationship between B.M.R. and thyroidal 131I uptake, but definite conclusions regarding the relationship between gastric acidity and age, B.M.R. and thyroid uptake cannot be drown until more cases of myxedema have been studied. The gestric acidity has been studied for 6 months to 2 years following the proper medical or surgical treatment in 12 patients with diffuse toxic goitre and in 8 patinets with myxedema. In most of them, the gastric acidity returned to within normal limits.
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증례 : 심한 단핵구증을 특징으로 한 급성 과립구성 백혈구 1 예
조방환 ( B. H. Cho ),김학열 ( H. Y. Kim ),이상종 ( S. J. Lee ),박정로 ( J. R. Park ),이유복 ( Y. B. Lee ) 대한내과학회 1970 대한내과학회지 Vol.13 No.11
Though many clinical studies of acute and chronic leukemias have been reported in this country, it was thought that there is lacking the report of acute granulocytic leukemia with monocytosis or myelomonocytic leukemia. We have seen recently such a patient
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조방환 ( B. H. Cho ),이영선 ( Y. S. Lee ),이돈성 ( D. S. Lee ),김학열 ( H. Y. Kim ),이상종 ( S. J. Lee ) 대한내과학회 1970 대한내과학회지 Vol.13 No.6
Disturbances of gastric secretion as related to thyroidal gland dysfunction have been noted for many years. In both old and recent literature one finds conflicting statements regarding the gastric contents in thyroidal diseases. King stated that in exophth
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