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중추도파민신경활성에 미치는 뇌기능개선 후보약물의 행동약리학적 연구
이순철,유관희,山本經之 충남대학교 약학대학 의약품개발연구소 1995 藥學論文集 Vol.11 No.-
The present study was undertaken to elucidate the behavioral characteristics of nootropic candidates, centrophenoxine, N-methyl-D-glucamine, piracetam and red ginseng saponin components on stereotyped sniffing behavior induced by apomorphine in rats. Apomorphine, a direct dopaminergic receptor agonist, induced stereotyped behaviors including sniffing, licking, gnowing and biting in a dose dependent manner, and that behaviors were completely inhibited when measured at 1 week after 6-hydroxydopamine(6-OHDA) treatment. Centrophenoxine, N-methyl-D-glucamine, red ginseng total sapomin (TS), panaxatriol (PT), and Rg_1 enhanced but panaxadiol (PD) inhibited, whereas priacetam and Rb1 were not effective of the stereotyped sniffing behavior induced by apomorphine (1 ㎎/㎏). The enhanced stereotyped behavior by centrophenoxine, N-methyl-D-glucamine, red ginseng total saponin, panaxatriol(PT), and Rg_1 was blocked by pretreatment of 6-OHDA. These results suggest that dopaminergic neuronal activity plays an important role in the action of some nootropic candidates. Red ginseng total saponin, panaxatriol and Rg_1 seems to have a similiarity to centrophenoxine, N-methyl-D-glucamate in modulating of dopaminergic neuronal activity and also may be useful for the nootropic candidates.