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식이성 인삼이 백서의 간 기능 저항 예방에 미치는 영향
강효신,조용호,신상주 ( Hyo Shin Kang,Yong Ho Cho,Sang Jou Shinn ) 생화학분자생물학회 1975 BMB Reports Vol.8 No.3
The enzymatic activity of serum glutamic-pyruvic transaminase is influenced by the addition of ginseng into diet at one percent level and the difference between the treatments is significant. at the same level of dietary protein, ginseng decreases slightly this enzymatic activity. Serum glutamic-oxaloacetic transaminase activity is highly influenced by dietary ginseng in rats administered with ethanol. The feeding of this plant to rats maintained with a same level of dietary protein significantly reduced its enzymatic activity. A similar tendency is also observed with the increase of dietary protein level. Both the addition of dietary ginseng and the increase in dietary protein level exert a profound influence on the enzymatic activity of serum lactic dehydrogenase, indicating that ginseng really hase protective effect on liver from deterioration caused by a prolonged and repeated ethanol ingestion.
식이성 인삼이 Alcoholic Rat 의 간 Vitamin A 와 혈액내 성분에 미치는 영향
강효신,조용호,신상주 ( Hyo Shin Kang,Yong Ho Cho,Sang Jou Shinn ) 생화학분자생물학회 1975 BMB Reports Vol.8 No.3
Preformed hepatic eitamin A conent was increased with the augmentation of dietary protein level in a significant rate but the reverse was true in the case of dietary ginseng treatment to alcoholic rats. Neither dietary protein level nor ginseng feeding changed the amount of serum protein, indicating that 14 percent of dietary protein satisfy the requirement of this nutrient in ethanol treated rats. Both the increase in protein level of diet and the feeding of ginseng tended to decrease blood cholesterol level in rats treated with ethanol for a period of four weeks. No definite changes were brought about on the blood glucose content either by an increase in dietary protein level or by the dietary ginseng treatment.
알츠하이머병 치매 환자에서 도네페질(Donepezil)에 대한 최초 투약군과 전환군 간의 임상적 효용 비교 평가 : 12개월 추적관찰 연구
강효신(Hyo Shin Kang),안인숙(Inn Sook Ahn),윤지혜(Ji Hae Yun),문유진(Yu Jin Moon),황태영(Tae Young Hwang),이영민(Young Min Lee),김혜란(Hyeran Kim),정재원(Jae Won Chung),김도관(Doh Kwan Kim) 대한노인정신의학회 2010 노인정신의학 Vol.14 No.2
Objectives : The purpose of this study was to compare the efficacy between switching patients with Alzheimer's disease (AD) from galantamine or rivastigmine to donepezil because they were not responding adequately, and naive patients with AD who initiated therapy with donepezil. Methods : A total of 108 patients were recruited for this 52-week study. The effect of donepezil on cognitive function was measured using Alzheimer's Disease Assessment Scale-cognitive subscale-preliminary Korean version (ADAS-cog-K). Patients' activities of daily living using Seoul-Activities of Daily Living (S-ADL) and the Seoul-Instrumental Activities of Daily Living (S-IADL);behavioral symptoms using the Korean version Neuropsychiatric Inventory (K-NPI) were measured at baseline, 13-weeks, 26-weeks, 39-weeks and 52-weeks. We defined the responsive patients to donepezil at those who showed a cognitive improvement or no change during the first six-month clinical trial. Results : 86 naive patients and 22 switching patients were enrolled in the study. 74 patients completed the study and 34 discontinued their treatment before week 52. There was no significant difference between two patient groups in demographic data, baseline characteristics and dementia severity except duration of illness. The total ADAS-cog-K scores were not significantly different from baseline after 52 weeks of treatment in both groups. Both groups demonstrated deterioration of S-ADL and S-IADL at 52 weeks. The NPI scores did not significantly change in both groups. Based on the operational criteria, 61.6% of the naive group and 54.5% of the switching group were responders to donepezil. Conclusion : The switching group had similar levels of efficacy with the naive group who initiated therapy with donepezil. These results suggest that patients not responding adequately to rivastigmine or galantamine may improve or stabilize after switching to donepezil and prior medication does not effect donepezil's efficacy.
치매환자 보호자 부양 부담의 요인구조 : 보호자 부담 조사의 탐색적 요인분석과 확인적 요인분석
강효신(Hyo Shin Kang),이수지(Soo Ji Lee),김지혜(Ji Hae Kim),권정혜(Jung Hye Kwon),김도관(Doh Kwan Kim) 대한노인정신의학회 2017 노인정신의학 Vol.21 No.2
Objective:Zarit Burden Interview (ZBI) was the most commonly used measure of caregiver burden for demented older adults. The aim of this study was to investigate dimensions of caregiver burden through factor analysis of ZBI. Methods:The participants were 706 outpatients with dementia and their caregivers in Korea. We assessed the caregiver burden using the Korean version of ZBI. The participants were randomly divided into two groups, for the purpose of identifying the most optimal factor structure through exploratory factor analysis in group 1 (n=368) and confirmatory factor analysis in group 2 (n=338). Results:The results of exploratory factor analysis in group 1 suggested 3-factor structure, which was labeled ‘personal strain,’ ‘patient dependency,’ and ‘self-criticism.’ The confirmatory factor analysis results indicated the 3-factor structure which was discovered through exploratory factor analysis was the best-fitting model for explaining the caregiver burden in group 2. Conclusion:The current study has significant implications for advancing our understanding of ZBI as multidimensional burden scale. Furthermore, differentiating the dimensions may allow researchers to assess the effects of interventions more precisely.
갈란타민(Galantamine) 투여 후 순수 알츠하이머병 치매와 혼합성 치매 환자의 주의력, 일상생활능력 및 신경정신행동 증상에 대한 효과 평가
강효신(Hyo Shin Kang),윤지혜(Ji Hae Yun),안인숙(Inn Sook Ahn),문유진(Yu Jin Moon),황태영(Tae Young Hwang),이영민(Young Min Lee),김혜란(Hyeran Kim),김도관(Doh Kwan Kim) 대한노인정신의학회 2012 노인정신의학 Vol.16 No.1
Objectives:The purpose of this study was to compare the efficacy of galantamine treatment, especially attention ability between patients with pure Alzheimer’s disease (AD) and Mixed dementia (MD) during a 24-week trial. Methods:A total of 40 patients were recruited for this 24-week study. The effect of galantamine on attention was measured using Seoul Computerized NeuroCognitive Function Test (SCNT) and frontal functions test of Seoul Neuropsychological Screening Battery (SNSB). Patients’activities of daily living using the Seoul-Activities of Daily Living (S-ADL) and the Seoul-Instrumental Activities of Daily Living (S-IADL) ; behavioral symptoms using the Korean version Neuropsychiatric Inventory (K-NPI) were measured at baseline and 24-week. Results:17 pure AD patients and 23 MD patients were analyzed in this study. Attention as measured by SCNT was not significantly different from baseline after 24 weeks of treatment in both groups. There was no significant difference between two groups in mean change from baseline in the SCNT, S-ADL, S-IADL and K-NPI scores at 24-week. Conclusion:Galantamine showed a therapeutic effect on cognition, activities of daily living, neuropsychiatric symptoms in pure AD and MD. Furthermore, Galantamine may specifically help to maintain attention and it may have positive effects on other cognitive and functional abilities.
순수 알츠하이머병 치매 환자군과 혼합성 치매 환자군에서 12개월간의 도네페질(Donepezil) 투여에 따른 치료 성적의 비교 평가
강효신(Hyo Shin Kang),안인숙(Inn Sook Ahn),윤지혜(Ji Hae Yun),문유진(Yu Jin Moon),황태영(Tae Young Hwang),이영민(Young Min Lee),김혜란(Hyeran Kim),정재원(Jae Won Chung),김도관(Doh Kwan Kim) 대한노인정신의학회 2010 노인정신의학 Vol.14 No.1
Objectives:The purpose of this study was to compare the efficacy of donepezil treatment between patients with pure Alzheimer’s disease (AD) and Mixed dementia (MD) during a 12-month trial. Methods:A total of 139 patients were recruited for this 52-week study. The effect of donepezil on cognitive function was measured using Alzheimer’s Disease Assessment Scale-cognitive subscale-preliminary Korean version (ADAS-cog-K). Patients’ activities of daily living using the Seoul-Instrumental Activities of Daily Living (S-IADL) and Seoul-Activities of Daily Living (S-ADL);behavioral symptoms using the Korean version Neuropsychiatric Inventory (K-NPI) were measured at baseline, 13-weeks, 26-weeks, 39-weeks and 52-weeks. We defined the responsive patients to donepezil at those who showed a cognitive improvement or no change during the first six-month clinical trial. Results:84 pure AD patients and 34 MD patients were available for intent-to-treat (ITT) last observation carried forward (LOCF) analysis. There was no significant difference between two groups in mean change from baseline in the total ADAS-cog-k, S-ADL, SIADL and K-NPI scores at 52-week. Based on the operational criteria, 60.7% of pure AD patients and 58.8% of MD patients were responders to donepezil. Conclusion:MD patients had similar levels of efficacy with pure AD patients and donepezil was well tolerated in both groups. These results suggest that donepezil is an effective and well-tolerated treatment for MD patients as well as for pure AD patients.
강효신,조용호,신상주 ( Hyo Shin Kang,Yong Ho Cho,Sang Jou Shinn ) 생화학분자생물학회 1975 BMB Reports Vol.8 No.3
Clearance rate of circulatory ethanol was definitely influenced by dietary ginseng and the differences between treatment were highly significant. On the contrary the increase in protein level did not affect the clearance rate of blood ethanol in rats. The dietary ginseng reversely affected the blood content of acetaldehyde; the higher the circulatory ethanol content, the lower the acetaldehyde content and the difference between treatments was highly significant. An increase in dietary protein level resulted in a higher content of acetaldehyde. The hepatic alochol dehydrogenase activity of rats given with one percent of dietary ginseng is definitely lower than that of control, the difference being highly significant.