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Sonoi, Mika,Kayashita, Jun,Yamagata, Yoshie,Tanimoto, Keiji,Miyamoto, Ken-ichi,Sakurama, Kazufumi Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.7
Aims: To determine suitable food textures for videofluoroscopic study of swallowing (VFSS), in order to predict and prevent subsequent aspiration pneumonia in esophageal cancer patients with dysphagia after surgery. Materials and Methods: We evaluated 45 hospitalized esophageal cancer patients who underwent surgery between January 2012 and December 2013. The control group consisted of 43 patients treatmed from January 2010 until December 2011 and were not examined by VFSS. Test foods, which were presented in order of increasing thickness, included thin barium sulfate (Ba) liquid (3 or 10 ml), slightly thickened Ba liquid (3 or 10 ml), a spoonful of Ba jelly, and a spoonful of Ba puree. Results: Patients could most safely swallow puree, followed by jelly. The 3-mL samples of both the thin and thick liquids put patients at risk for aspiration pneumonia, with incidence rates of 13% and 11%, respectively. While 64.4% of patients could swallow all test foods and liquids safely, 35.6% were at risk for aspiration pneumonia when swallowing liquids. Even though >30% of patients were at risk, only 1 (2.2%) in the VFSS group developed aspiration pneumonia, which occurred at the time of admission. Following VFSS, no incidence of aspiration pneumonia was observed. However, aspiration pneumonia occurred in 4 (9.3%) control patients during hospitalization. Conclusions: Postoperative esophageal cancer patients were more likely to aspirate any kind of liquid than solid foods, such as jellies. VFSS is very useful in determining suitable food textures for postoperative esophageal cancer patients.
Park, Hee-Juhn,Kwon, Sang-Hyuk,Han, Yong-Nam,Choi, Jong-Won,Miyamoto, Ken-ichi,Lee, Sung-Ho,Lee, Kyung-Tae The Pharmaceutical Society of Korea 2001 Archives of Pharmacal Research Vol.24 No.4
In a course of obtaining more amount of bioactive costunolide and successive phytochemical isolation from Magnolia sieboldii (Magnoliaceae), a novel acyclic monoterpene 1 named deoxygeraniol (2,6(E)-dimethyl-2,6-octadiene) was isolated along with $\beta$-sitosterol 3-O-linoleate (2), trilinolein (3) and high amount of costunolide (4) in the pure state. The structure of compound 1 was determined on the basis of spectroscopic data. Costunolide was found to induce apoptotic cell death in a dose-dependent manner by nucleosomal DNA ladder and flow cytometric analysis. Immunoblot analysis showed that the level of the anti-apoptotic protein, Bcl-2, was decreased, whereas the cleavage of poly-(ADP-ribose) polymerase was, activated furthermore, the N-acetyl-L-cysteine antioxidant effectively prevented costunolide-induced cytotoxicity. These results suggest that costunolide-induced cell death is mediated by reactive oxygen species.
Park, Hee-Juhn,Kwon, Sang-Hyuk,Lee, Joo-Han,Lee, Kyou-Heung,Miyamoto, Ken-ichi,Lee, Kyung-Tae 경희대학교 동서의학연구소 2001 東西醫學硏究所 論文集 Vol.2001 No.-
Hederagenin, δ-hederin {hederagenin α_-L-arabinoside}, kalopanax-saponin A (hederagenin 3-O-α_-L-rhamnosyl(1→2) -α_-L-arabinoside}, kalopanaxaponin I {hederagenin 3-O-β-_D-xylosyl(1→3)-α-_L-rhamnosyl(1→2)-α-L-arabinoside}, and sapindoside C {hederagenin 3-O-β-_D-glucosyl(1→4)-β-_D-xylosyl(1→3)-α-_L-rhamnosyl(1→2)-α-_L-arabinoside} were isolated from stem bark of Kalopanax pictus Nakai (Araliaceae). Among glycosides of hederagenin, disaccharide (kalopanaxaponin A, commonly also called α-hederin), trisaccharide (kalopanaxaponin l), and tetrasaccharide (sapindoside C) showed significant cytotoxicity on several types of tumor cells, while hederagenin itself exhibited only weak cytotoxicity and its monosaccharide (δ-hederin) was non-cytotoxic. From these results, it suggests that the arabinosyl moiety at C-3 blocks the activity of hederagenin and the position of the second sugar for glycoside linkage is also important for cytotoxicity. In the in vivo experiments, kalopanaxsaponin A (15 mg/kg, i.p.) apparently increased the life span of mice bearing Colon 26 and 3LL Lewis lang carcinoma, as well as cisplatin (3 mg/kg, i.p.). These results indicated that kalopanaxsaponin A has potential anti-tumor applications.
Park, Hee Juhn,Kwon, Sang Hyuk,Han, Yong Nam,Choi, Jong Won,Miyamoto, Ken-ichi,Lee, Sung Ho,Lee, Kyung Tae 경희대학교 동서의학연구소 2001 東西醫學硏究所 論文集 Vol.2001 No.-
In a course of obtaining more amount of bioactive costunolide and successive phytochemical isolation from Magnolia siegoldii (Magnoliaceae), a novel acyclic monoterpene 1 named deoxygeranlol {2,6(E)-dimethyl-2,6-octadiene} was isolated along with β-sitosterol 3-O-linoleate (2), trilinolein (3) and high amount of costunolide (4) in the pure state. The structure of compound 1 was determined on the basis of spectroscopic data. Costunolide was found to induce apoptotic cell death in a dose-dependent manner by nucleosomal DNA ladder and flow cytometric analysis. Immunoblot analysis showed that the level of the anti-apoptotic protein, Bcl-2, was decreased, whereas the cleavage of poly-(ADP-ribose) polymerase was activated. Furthermore, the N-acetyl-L-cysteine antioxidant effectively prevented costunolide-induced cytotoxicity. These results suggest that costunolide-induced cell death is mediated by reactive oxygen species.
Studies on Constituents with Cytotoxic Activity from the Stem Bark of Syringa velutina
HAN, Yong-Nam,LEE, Kyung-Tae,PARK, Hee-Juhn,LEE, Myung-Sun,SOHN, Il-Cheol,MIYAMOTO, Ken-ichi WHO COLLABORATING CENTRE FOR TRADITIONAL MEDICINE 1999 東西醫學硏究所 論文集 Vol.1999 No.-
Cytotoxic compounds, oleuropein (1) and a phenylethanoid glycoside (2) were isolated from the stem bark ot Syringa velutinu Kom. along with coniferydehyde 4-0-glucoside, syringin, ligstroside (+)-syringaresinol 4-0-glucoside, (+)-medioresinol 4"-0-glucoside and (-)-olivil 4"-0-glucoside. Phenylethanoid glycoside (2) was identified to be 3,4-dihydroxyphenylethyl alcohol 8-0-β-D-glucopyranoside. This compound showed the most potent cytotoxic effect on several tumor cell lines (P-388, L-1210, SNU-5 and HL-60) among eight compounds isolated in the present study. We suggest that the 3,4-dihydroxvphenylethoxy moiety of this compound contributes to cytotoxicity.
Lee, Kyung-Tae,Kim, Joo-Il,Park, Hee-Juhn,Yoo, Ki-Oug,Han, Yong-Nam,Miyamoto, Ken-ichi 경희대학교 동서의학연구소 2001 東西醫學硏究所 論文集 Vol.2000 No.-
Cichorium intybus contains 1β-hydroxyeudesmanolides, magnolialide and artesin, together with several constituents. Magnolialide inhibits the growth of several tumor cell lines and appears to induce differentiation of human leukemia HL-60 and U-937 cells to monocyte/macrophage-like cells. Another 1β-hydroxyeudesmanolide, artesin, and other constituents were inactive. The content of magnolialide was shown to be highest in the leaves of Inje cultivar among the cultivars investigated in this study.
Hypericin Induces Both Differentiation and Apoptosis in Human Promyelocytic Leukemia HL-60 Cells
JUNG, Jee-Chang,CHANG, Seoung-Goo,Lee, Kyung Tae,RHO, Young-Soo,KIM, Joo-Il,PARK, Jae-Hoon,PARK, Hee-Joun,MIYAMOTO, Ken-ichi WHO COLLABORATING CENTRE FOR TRADITIONAL MEDICINE 1999 東西醫學硏究所 論文集 Vol.1999 No.-
Hpperiein is a unique photosensitizing, plant pigment and has been separately reported to induce differentiation and apotosis in neoplastiec cells, In this study, we examined the relationship between activities to induce differerentiation and apoptosis in human promyelocytic leukemia HL-60 cells, at a concentration range of 0.15 to 0.2㎛. When treated with hypericin, the cell ratio reducible of nitroblue tetrazolium was significantly increased and the cell size was enlarged by flow cytometry analysis. Hypericin also significantly increased the ratio of the cells, which were of positive α-naphthyl acetate esterasc activity and phagocytic activity, whereas it hardly influenced the naphthol AS-D chloroacetate esterase activity in the cells, as well as l α25(OH)₂D₃, ( ). ln addition, hypericin increased hypodiploid nuclei and caused a nucleosomal ladder. These results indicate that hypericin induces both differentiation toward monocyte/macrophagc lineage and apoptosis in HL-60 cells.
Lee, Kyung-Tae,Sohn, Il-Cheol,Kim, Young-Kwan,Chio, Jung-Hye,Choi, Jong-Won,Park, Hee-Juhn,Itoh, Yoshie,Miyamoto, Ken-ichi 경희대학교 경희동서약학연구소 2001 경희약대 논문집 Vol.29 No.-
Cytotoxic effects of six isoflavonoids, tectorigenin, glycitein, tectoridin, glycitin, 6”-O-xylosyltectoridin, and 6”-O-xylosylglycitin isolated from the flower of Pueraria thunberglane BENTH, together with genistein, a known differentiation and apoptosis inducer, were examined. Among these isoflavonoids, Tectorigenin and genistein exhibited cytotoxicity against various human cancer cells; glycitein showed only mild cytotoxicity. These results suggest that the isoflavone structure and S-hydroxyl group are crucial for the cytotoxic properties and that glycosides are inactive. Moreover, tectorigenin induced differentiation of human promyelocytic leukemia HL-60 cells to granulocytes and monocytes/macrophages, and caused apoptotic changes of DNA in the cells, as did genistein. Tectorigenin also inhibited autophosphorylation of epidermal growth factor (EGF) receptor by EGF and decreased the expression of Bel-2 protein, with less activity than genistein. From these results, tectorigenin may be a possible therapeutic agent for leukemia.