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      • Experimental Study on Spray Characteristics of The Internal Impinging Nozzle

        ( Jiachen Zhai ),( Zongjie Hu ),( Wei Xie ),( Huizhi Chen ),( Cong Xue ),( Yufeng Wang ),( Zhijun Wu ) 한국액체미립화학회 2017 한국액체미립화학회 학술강연회 논문집 Vol.2017 No.-

        The internal impinging nozzle with a bluff body set inside can form a periodic oscillating spray, which is a novel approach of atomization. In this paper, the flow distribution characteristics of the spray are studied with low-pressure water as the medium. Meanwhile, the characteristics of spray cone angle, oscillating frequency, spatial distribution of droplet velocity and particle size are also studied with high-speed Schllieren technique and Malwen particle size analyzer. The results demonstrate that with the increase of the injection pressure, the spray cone angle is almost constant, while the spray oscillating frequency increases gradually, which is tantamount to the variation trend of axial velocity and radial velocity of the droplet. When the injection pressure is elevated from 0.16MPa to 0.18MPa, at the same position, the increase of droplet axial velocity distinctly reaches a maximum. Furthermore, with the development of the spray, the particle size decreases accordingly, and the velocity of the well atomized area near the spray symmetrical center axis is also gradually reduced. The farther away from the nozzle outlet, the more pronounced the symmetry of the spatial distribution of the axial velocity and radial velocity becomes. Moreover, when the injection pressure reaches 0.16MPa, at the position 250mm away from the outlet, the particle size achieves a minimum, and the spray obtains a stable distribution, which is rarefied and uniform in the middle area, while generous on both sides. With the injection pressure increasing to 0.18MPa, the flow of the well atomized area near the spray symmetrical center axis reaches its maximum, and that of the area farthest away from the symmetry center is also raised by degrees as the injection pressure increases.

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        Long noncoding RNA NEAT1 is involved in the protective effect of Klotho on renal tubular epithelial cells in diabetic kidney disease through the ERK1/2 signaling pathway

        Yan-Lin Yang,Meng Xue,Yijie Jia,Fang Hu,Zongji Zheng,Ling Wang,Ze-Kun Si,Yaoming Xue 생화학분자생물학회 2020 Experimental and molecular medicine Vol.52 No.-

        Klotho, an antiaging protein, has been shown to play a protective role in renal tubular epithelial-mesenchymal transition (EMT) during the development of diabetic kidney disease (DKD). Long noncoding RNAs (lncRNAs) participate in the progression of EMT in many diseases. However, the effect of Klotho on lncRNAs during the development of DKD is still unknown. In this study, we found that Klotho overexpression in high-fat diet (HFD)- and streptozotocin (STZ)- induced DKD mice significantly inhibited the expression of lncRNA nuclear-enriched abundant transcript 1 (Neat1). We demonstrated that NEAT1 was significantly upregulated in both bovine serum albumin (BSA)-stimulated HK2 cells and mice with HFD- and STZ-induced diabetes. In addition, we observed that Klotho displays colocalization with NEAT1. Furthermore, overexpression of Klotho can inhibit the high expression of NEAT1 in BSA-stimulated HK2 cells, while silencing Klotho can further upregulate the expression of NEAT1. Silencing NEAT1 in HK2 cells resulted in inhibition of the EMT-related markers alpha smooth muscle actin (α-SMA) and vimentin (VIM) and the renal fibrosis-related markers transforming growth factor-β1 (TGF-β1) and connective tissue growth factor (CTGF). The effect of NEAT1 on DKD was partly mediated by regulation of the ERK1/2 signaling pathway. Finally, we found that silencing NEAT1 can reverse the activation of EMT and fibrosis caused by Klotho silencing in a manner dependent on the ERK1/2 signaling pathway. These findings reveal a new regulatory pathway by which Klotho regulates ERK1/2 signaling via NEAT1 to protect against EMT and renal fibrosis, suggesting that NEAT1 is a potential therapeutic target for DKD.

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        Development of a 120 Hz 110 ultra-high-definition a-Si liquid crystal display panel

        Yanping Liao,Xibin Shao,Yufan Du,송용지,Weihao Hu,Zhenyu Zhang,Yuqiong Chen,Ying Wang,Qing Ma,윤대근,Dan Wang,Jianfeng Yuan,Hongjiang Wu,Zongjie Guo,Zhaohui Hao,Ji Zhang,Jing Lv 한국정보디스플레이학회 2014 Journal of information display Vol.15 No.2

        A prototype 120 Hz 110-inch ultra-high-definition a-Si liquid crystal display (LCD) panel was successfully developed using the BOE exclusive advanced superdimensional switching technology. This LCD has a panel consisting of 3840 × 2160 pixels, four times the number of pixels in the conventional full-high-definition LCD. For the brightness and contrast ratio, 1000 nits and 1200:1 have been achieved, respectively. Additionally, the liquid crystal charging time has been extended through quad area driving and 2G2D line structures. Furthermore, the local dimming and mirror-scanning techniques are applied to realize excellent image display. Finally, the system utilizes 3D shutter glasses, allowing the viewer to achieve the highest sense of realness and immersion.

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