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Xufeng Xiao,Caijun Wu,Zhiyun Xu,Yingui Yang,Shuying Fan,Heng Wang 한국유전학회 2015 Genes & Genomics Vol.37 No.4
Bolting and flowering enhance the commercial value of flowering Chinese cabbage. FLOWERING LOCUS C (FLC) and FRIGIDA (FRI) are two key flowering time genes in Arabidopsis thaliana. Here we reported on the cloning and characterization of three ‘classical’ genes from the autonomous pathway from flowering Chinese cabbage, BrcuFCA, BrcuFLD and BrcuFVE. The results of expression analysis showed BrcuFLC was a gradually up-regulated with the developmental stages. However, temporal mRNA expression of BrcuFRI, BrcuFCA, BrcuFVE, and BrcuFLD were found to follow the opposite transcription patterns. The spatial expression patterns of BrcuFCA, BrcuFLD, and BrcuFVE were similar with the highest levels in flowers, whereas the highest transcription levels of BrcuFLC occurred in leaves and stems and that of BrcuFRI in roots. We presumed that the main pathway of bolting– flowering regulation in flowering Chinese cabbage might be the autonomous pathway and different from the vernalization pathway and FRI-dependent pathway.
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TIEJUN ZHAO,HEZHONG CHEN,LIXIN YANG,HAI JIN,ZHIGANG LI,LIN HAN,FANGLIN LU,ZHIYUN XU 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2013 NANO Vol.8 No.2
Oral chemotherapy is a great way to cancer treatment because it is less stressful being that the patient will have less hospital visits and can still maintain a close relationship with health care professionals. In this research, three types of nanoparticle formulation from commercial PCL and self-synthesized TPGS-b-(PCL-ran-PGA) diblock copolymer were fabricated for oral delivery of antitumor agents, including DDAB-modified PCL nanoparticles, unmodified TPGS-b-(PCL-ran-PGA) nanoparticles and DDAB-modified TPGS-b-(PCL-ran-PGA) nanoparticles. Firstly, the TPGS-b-(PCL-ran-PGA) diblock copolymer was synthesized and characterized. DDAB was adopted to increase retention time at the cell surface, thus increasing the chances of nanoparticle uptake by the gastrointestinal mucosa and improving drug absorption. The TPGS-b-(PCL-ran-PGA) nanoparticles were found by FESEM of spherical shape and around 200 nm in diameter. The surface charge of TPGS-b-(PCL-ran-PGA) nanoparticles was reversed from anionic to cationic after DDAB modification. The DDAB-modified TPGS-b-(PCL-ran-PGA) nanoparticles have significantly higher level of the cell uptake than that of DDAB-modified PCL nanoparticles and unmodified TPGS-b-(PCL-ran-PGA) nanoparticles. In vitro cell viability studies showed advantages of the DDAB-modified TPGS-b-(PCL-ran-PGA) nanoparticles over Taxotere® in terms of cytotoxicity against A549 cells. In conclusion, oral chemotherapy by DDAB-modified TPGS-b-(PCL-ran-PGA) nanoparticle formulation may provide a promising outcome for lung cancer patients.
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Xiaoqin Ha,Junhua Peng,Hongbin Zhao,Zhiyun Deng,Juzi Dong,Hongyan Fan,Yong Zhao,Bing Li,Qiangsheng Feng,Zhihua Yang 대한의학회 2017 Journal of Korean medical science Vol.32 No.2
The present study developed an oral hepatocyte growth factor (HGF) gene therapy strategy for gastric ulcers treatment. An attenuated Salmonella typhimurium that stably expressed high HGF (named as TPH) was constructed, and the antiulcerogenic effect of TPH was evaluated in a rat model of gastric ulcers that created by acetic acid subserosal injection. From day 5 after injection, TPH (1 × 109 cfu), vehicle (TP, 1 × 109 cfu), or sodium bicarbonate (model control) was administered orally every alternate day for three times. Then ulcer size was measured at day 21 after ulcer induction. The ulcer area in TPH-treated group was 10.56 ± 3.30 mm2, which was smaller when compared with those in the TP-treated and model control groups (43.47 ± 4.18 and 56.25 ± 6.38 mm2, respectively). A higher level of reepithelialization was found in TPH-treated group and the crawling length of gastric epithelial cells was significantly longer than in the other two groups (P < 0.05). The microvessel density in the ulcer granulation tissues of the TPH-treated rats was 39.9 vessels/mm2, which was greater than in the TP-treated and model control rats, with a significant statistical difference. These results suggest that TPH treatment significantly accelerates the healing of gastric ulcers via stimulating proliferation of gastric epithelial cells and enhancing
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( Xinhui Wang ),( Xiaoli Liu ),( Zhibo Dang ),( Lihua Yu ),( Yuyong Jiang ),( Xianbo Wang ),( Zhiyun Yang ) 대한간학회 2020 Gut and Liver Vol.14 No.2
Background/Aims: Studies have shown that nucleos(t)ide analogue (NA) treatment can reduce the risk of hepatocel lular carcinoma (HCC) in chronic hepatitis B (CHB) patients, but it is unclear which NA is most effective. We performed a meta-analysis and systematic review comparing the effica cies of NAs in CHB patients. Methods: We searched litera ture databases for randomized controlled trials (RCTs) and observational studies that analyzed the hepatic biochemical response, virological response, seroconversion rate, drug re sistance rate, and HCC incidence rate in CHB patients treat ed with NAs. Meta-analyses were performed with RevMan and Stata/SE software. Results: Twelve cohort studies and one RCT were selected, in which entecavir (ETV), lamivudine (LAM), telbivudine (LdT), and/or tenofovir disoproxil fumarate (TDF) were evaluated in CHB patients. The meta-analysis showed that ETV was superior to LAM with regard to the HCC incidence (p<0.001), biochemical response (p=0.001), viro logical response (p=0.02), and drug resistance (p<0.001), and ETV was superior to LdT with regard to the virological re sponse (p<0.001) and drug resistance (p<0.001). We found no significant difference between ETV and TDF with regard to the HCC incidence (p=0.08), biochemical response (p=0.39), virological response (p=0.31), serological conversion (p=0.38), or drug resistance (p=0.95). NA-treated patients with pre-existing cirrhosis had a 5.49 times greater incidence of HCC than those without cirrhosis (p<0.001). Conclusions: ETV or TDF should be used for long-term first-line mono therapy in CHB patients according to the current guidelines. Standardized protocols are needed for future studies of ETV and TDF to facilitate conclusive comparisons. Patients with cirrhosis are at significantly elevated risk for HCC, despite the benefits of NA treatment. (Gut Liver 2020;14:232-247)
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