TEC Genetic Polymorphism is Associated with TNF-α Inhibitor Treatment Response in Rheumatoid Arthritis Patients

Jun Hyeob Kim(Jun Hyeob Kim),Woorim Kim(Woorim Kim),Jin Yeon Gil(Jin Yeon Gil),Kyung Hyun Min(Kyung Hyun Min),Ji Min Han(Ji Min Han),Kyung Eun Lee(Kyung Eun Lee) 대한약학회 2023 약학회지 Vol.67 No.3

Numerous genetic and clinical factors influence the progression of rheumatoid arthritis and treatment response. Single nucleotide polymorphisms (SNPs) have been associated with different treatment responses in TNF-α inhibitor users. This study aimed to determine if Tec protein tyrosine kinase (TEC), which belongs to the Tec family of non-receptor protein tyrosine kinases, is associated with treatment response in rheumatoid arthritis (RA) patients. RA patients from three university hospitals were recruited, and clinical data were collected from electronic medical records. One hundred fourteen patients treated with TNF-α inhibitor were included in the analysis. SNP-response associations were evaluated using logistic regression. Among the five SNPs analyzed, rs1472971 and rs11727166 were statistically significant genetic factors of TNF-α inhibitor treatment response. This study provides genetic evidence that TEC polymorphism can be a prognostic marker in treating RA patients.

Pseudahrensia todarodis sp. nov., isolated from the gut of a Japanese flying squid, Todarodes pacificus

Kim, Hyun Sik,Kim, Pil Soo,Hyun, Dong-Wook,Lee, June-Young,Kang, Woorim,Shin, Na-Ri,Whon, Tae Woong,Bae, Jin-Woo Microbiology Society 2016 International journal of systematic and evolutiona Vol.66 No.-

<P>A novel Gram-stain-negative, non-motile, non-spore-forming, non-flagellated, aerobic, beige-coloured and rod-shaped bacterium, designated strain KHSO2(T), was isolated from the intestinal tract of a Japanese flying squid, Todarodes pacificus, which was collected from the East Sea, Korea. Phylogenetic analysis of 16S rRNA gene sequences revealed that strain KHSO2(T) formed a monophyletic Glade with Pseudahrensia aquimaris HDW-32(T), with which it had the highest sequence similarity (98.67 %). Strain KHS02(T) grew optimally at pH 7 with 2 % (w/v) NaCI at 25 degrees C on marine broth 2216, but could not grow without Nat The predominant isoprenoid quinone was ubiquinone-10 (C1-10). The major fatty acids (>10 % of the total) were summed feature 8 C-18 : (1)omega 7C and/or C-18 : (1)omega 7C and 11-methyl C-18 : (1)omega 7C. The polar lipids of strain KHSO2(T) comprised phosphatidylcholine, phosphatidylglycerol, phosphatidylethanolamine, two unidentified aminolipids, an unidentified phospholipid and an unidentified lipid. The genomic DNA G+C content was 58.6 mol%. DNA DNA hybridization showed that the isolate shared 16.2+1.3 % (reciprocal, 15.7 +/- 2.8 %) genomic relatedness with the type strain of the closest species. In conclusion, this isolate is suggested to represent a novel species of the genus Pseudahrensia, for which the name Pseudahrensia todarodis is proposed. The type strain is KHSO2(T) (=KACC 18257(T)=JCM 30419(T)).</P>

Does having various types of fear related to COVID-19 disrupt individuals’ daily life?: Findings from a nationwide survey in Korea

Kim Woorim,Ju Yeong Jun,이순영 한국역학회 2022 Epidemiology and Health Vol.44 No.-

OBJECTIVES: Unexpected changes in daily routines caused by the coronavirus disease 2019 (COVID-19) pandemic may affect psychological health. This study investigated the association between various types of COVID-19-related fear and the subjective level of disturbance in daily activities experienced by individuals. METHODS: This cross-sectional study used the Korea Community Health Survey conducted from August through November 2020. COVID-19-related fear included fear of infection, death, public criticism, family members getting infected, and economic loss. The subjective level of disruption in daily activities was measured using a 0-100 numeric rating scale developed by the Korea Disease Control and Prevention Agency. Multivariable linear regression was used to analyze the associations between the independent and dependent variables. A subgroup analysis was performed based on income level. RESULTS: Participants who reported fear of infection (β= -3.37, p< 0.001), death (β= -0.33, p= 0.030), public criticism (β= -1.63, p< 0.001), a family member getting infected (β= -1.03, p< 0.001), and economic loss (β= -3.52, p< 0.001) experienced more disturbances in daily activities. The magnitude of this association was most significant in the lowest-income group. CONCLUSIONS: Individuals reporting COVID-19-related fear experienced higher levels of subjective disruption in daily activities.

The Ability to Rest at Home During COVID-19 Symptom Manifestation and Depressive Symptoms: Evidence From Korea

Woorim Kim,Yeong Jun Ju,Soon Young Lee 대한신경정신의학회 2022 PSYCHIATRY INVESTIGATION Vol.19 No.2

Objective This study investigated the association between ability to rest at home in times of coronavirus disease 2019 (COVID-19) symptom manifestation and depressive symptoms.Methods The 2020 Korea Community Health Survey data were used. The presence of depressive symptoms was determined using the Patient Health Questionnaire-9. The relationship between depressive symptoms and ability to rest at home was examined using logistic regression analysis. Additional analysis was performed on the reasons for the inability to stay at home.Results Depressive symptoms were more common in participants who could not rest at home if symptoms manifested (4.1%) than those who could rest at home (2.7%). Participants who could not rest at home (OR 1.53, 95% CI 1.34–1.74) were more likely to have depressive symptoms, particularly when they had to report to work (OR 1.50, 95% CI 1.30–1.74) or purchase daily necessities (OR 2.40, 95% CI 1.15–5.03).Conclusion Inability to rest at home in the case of COVID-19 symptom manifestation was associated with depressive symptoms. The findings suggest the need to address the identified vulnerable groups to mitigate the mental health consequences of the pandemic.

Regional Differences in Access to Clinical Trials for Cancer in Korea

Kim, Woorim,Jang, Seongkyeong,Chang, Yoon Jung Korean Society for Quality in Health Care 2021 한국의료질향상학회지 Vol.27 No.1

Purpose: The ability to access clinical trials for cancer treatment is important. This study investigated whether regional differences exist in oncologic clinical trial protocols conducted in South Korea. Methods: Records of all approved oncologic clinical trials conducted in 2019 were downloaded from the Republic of Korea Ministry of Food and Drug Safety. The study covered Seoul, the capital area, other metropolitan cities, and provincial areas. Descriptive statistics summarized the distribution patterns of clinical trials by region. Results: A total of 202 oncologic clinical trials were conducted in 63 institutions in 2019. Of these protocols, 186 (92%) were available in Seoul, 120 (59%) in the capital area, 64 (32%) in metropolitan cities, and 66 (33%) in provincial areas. More regional differences in protocol availability were observed in domestic trials, investigator-initiated trials, phase 1 and 2 trials, and smaller-scale trials. Conclusion: Most oncologic clinical trials were conducted in medical institutions located in Seoul, with the rest conducted in the capital area, metropolitan cities, and provincial areas. The findings reveal clear differences in protocol availability between Seoul and the other regions. Measures designed to improve geographical access to oncologic clinical trials may be needed given their growing importance in cancer treatment.

Sedimentitalea todarodis sp. nov., isolated from the intestinal tract of a Japanese flying squid

Kim, Hyun Sik,Hyun, Dong-Wook,Lee, June-Young,Kim, Pil Soo,Whon, Tae Woong,Kang, Woorim,Bae, Jin-Woo Microbiology Society 2016 International journal of systematic and evolutiona Vol.66 No.-

Impact of Changes in Medical Aid Status on Health Care Utilization

( Woorim Kim ),( Chung Mo Nam ),( Sang Gyu Lee ),( Sohee Park ),( Tae Hyun Kim ),( Eun-cheol Park ) 한국보건행정학회 2019 보건행정학회지 Vol.29 No.4

Background: South Korea operates a Medical Aid (MA) program targeting selected low-income individuals to ensure medical service delivery to the disadvantaged while enhancing self-sufficiency of work-capable beneficiaries. However, as reasons behind welfare exits are diverse and do not always infer poverty relief or the provision of appropriate levels of health care services, this study aimed to investigate the association between changes in MA status and health care utilization. Methods: This study used the 2006 to 2015 National Health Insurance claims data. The impact of changes in annual MA status on health care utilization (yearly number of outpatient visits, inpatient visits, length of stay, and emergency department [ED] visits) was investigated using the generalized estimating equation model. Results: In 117,943 adult subjects aged 20 to 64, compared to the ‘MA to MA’ group, the ‘MA to MA exit’ group showed general decreases in utilization (outpatient visits: β=-3.93, p<0.0001; hospital admissions: relative risk [RR], 0.87; 95% confidence interval [CI], 0.83-0.91; length of stay: β=-3.64, p<0.0001; ED visits: RR, 0.83; 95% CI, 0.77-0.90). Similar patterns were found in the ‘MA exit to MA exit’ group (outpatient visits: β=-5.72, p<0.0001; admissions: RR, 0.91; 95% CI, 0.87-0.94; length of stay: β=-5.87; p<0.0001; ED visits: RR, 0.81; 95% CI, 0.75-0.88). Likewise, in 74,747 older adult subjects aged 65 or above, the ‘MA to MA exit’ group showed reduced levels of utilization (outpatient visits: β=-1.51; p=0.0020), as well as the ‘MA exit to MA exit’ group (admissions: RR, 0.92; 95% CI, 0.89-0.95; length of stay: β, -5.45; p<0.0001; ED visits: RR, 0.90; 95% CI, 0.83-0.97). Conclusion: MA exit was associated with general decreases in health care utilization. Utilization patterns of individuals with experiences of receiving MA benefits should be monitored to promote the ideal use of health care services while preventing potential financial barriers present in accessing medical care.

2015 재난적 의료비 경험률과 추이

김우림 ( Woorim Kim ),박은철 ( Eun-cheol Park ) 한국보건행정학회 2017 보건행정학회지 Vol.27 No.1

Catastrophic healthcare expenditure refers to out-of-pocket spending for healthcare exceeding a certain proportion of a household`s income and can lead to subsequent impoverishment. The aim of this study was to investigate the proportion of South Korean households that experienced catastrophic healthcare expenditure between 2006 and 2015 using available data from the Korea Health Panel, National Survey of Tax and Benefit, and Household Income and Expenditure Survey. Frequencies and trend tests were conducted to analyze the proportion of households with catastrophic healthcare expenditure. Subgroup analysis was performed based on income level. The results of the Household Income and Expenditure Survey revealed that around 2.88% of households experienced catastrophic healthcare expenditure in 2015 and that this proportion was highest in the low income group. Results also showed a statistically significant increasing trend in the number of households with catastrophic healthcare expenditure (annual percentage change=0.92%, p-value <0.0001). Therefore, the findings infer a need to strengthen public health care financing and to particularly monitor catastrophic healthcare expenditure in the low income group.

정수 및 하수처리 공정에서 오존 및 UV/H₂O₂ 시스템적용 시의 할로겐화 메틸파라벤류의 반응 동역학 및 제거효율 평가

이우림(Woorim Lee),이윤호(Yunho Lee),염훈식(Hoon-Sik Yeom),김희영(Hee-Young Kim),정태욱(Taeuk Jeong),김상구(Sang-Goo Kim),손희종(Heejong Son) 대한환경공학회 2021 대한환경공학회 학술발표논문집 Vol.2021 No.11

암환자의 진단-치료 소요기간에 따른 생존분석과 지역사회별 격차 및 시계열적 추이

김우림 ( Woorim Kim ),한규태 ( Kyu-tae Han ) 한국보건행정학회 2021 보건행정학회지 Vol.31 No.1

Background: The Korean government introduced National Cancer Control Program and strengthening national health insurance coverage for cancer patients. Although many positive effects have been observed, there are also many concerns about cancer management such as patient concentration or time-to-treatment. Thus, we investigated the association between the time-to-treatment and survival of cancer patients, and compared regional differences by time trend. Methods: The data used in this study were national health insurance claims data that included patients diagnosed with lung cancer and received surgical treatment between 2005 and 2015. We conducted survival analysis with Cox proportional hazard model for the association between time-to-treatment and survival in lung cancer. Additionally, we compared the regional differences for time-to-treatment by time trend. Results: A total of 842 lung cancer patients were included, and 52.3% of lung cancer patients received surgical treatment within 30 days. Patients who received surgical treatment after 31 days had higher 5-year or 1-year mortality compared to treatment within 30 days (5-year: hazard ratio [HR], 1.566; 1-year: HR, 1.555; p<0.05). There were some regional differences for time-to-treatment, but it was generally reduced after 2010. Conclusion: Delayed surgical treatment after diagnosis can negatively affect patient outcomes in cancer treatment. To improve cancer control strategies, there are needed to analyze the healthcare delivery system for cancer care considering the severity and types of cancer.