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- 저자 : ( Wei Xiong ) (검색결과 148 건)
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Xiong, Wei,Jiang, Yong-Xin,Ai, Yi-Qin,Liu, Shan,Wu, Xing-Rao,Cui, Jian-Guo,Qin, Ji-Yong,Liu, Yan,Xia, Yao-Xiong,Ju, Yun-He,He, Wen-Jie,Wang, Yong,Li, Yun-Fen,Hou, Yu,Wang, Li,Li, Wen-Hui Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.8
Background: Preoperative 5-fluorouracil (5-FU)-based chemoradiotherapy is a standard treatment for locally advanced colorectal cancer (CRC). However, CRC cells often develop chemoradiation resistance (CRR). Recent studies have shown that long non-coding RNA (lncRNA) plays critical roles in a myriad of biological processes and human diseases, as well as chemotherapy resistance. Since the roles of lncRNAs in 5-FU-based CRR in human CRC cells remain unknown, they were investigated in this study. Materials and Methods: A 5-FU-based concurrent CRR cell model was established using human CRC cell line HCT116. Microarray expression profiling of lncRNAs and mRNAs was undertaken in parental HCT116 and 5-FU-based CRR cell lines. Results: In total, 2,662 differentially expressed lncRNAs and 2,398 mRNAs were identified in 5-FU-based CRR HCT116 cells when compared with those in parental HCT116. Moreover, 6 lncRNAs and 6 mRNAs found to be differentially expressed were validated by quantitative real time PCR (qRT-PCR). Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis for the differentially expressed mRNAs indicated involvement of many, such as Jak-STAT, PI3K-Akt and NF-kappa B signaling pathways. To better understand the molecular basis of 5-FU-based CRR in CRC cells, correlated expression networks were constructed based on 8 intergenic lncRNAs and their nearby coding genes. Conclusions: Changes in lncRNA expression are involved in 5-FU-based CRR in CRC cells. These findings may provide novel insight for the prognosis and prediction of response to therapy in CRC patients.
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Parecoxib: an Enhancer of Radiation Therapy for Colorectal Cancer
Xiong, Wei,Li, Wen-Hui,Jiang, Yong-Xin,Liu, Shan,Ai, Yi-Qin,Liu, Rong,Chang, Li,Zhang, Ming,Wang, Xiao-Li,Bai, Han,Wang, Hong,Zheng, Rui,Tan, Jing Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.2
Background: To study the effect of parecoxib, a novel cyclooxygenase-2 selective inhibitor, on the radiation response of colorectal cancer (CRC) cells and its underlying mechanisms. Materials and Methods: Both in vitro colony formation and apoptosis assays as well as in vivo mouse xenograft experiments were used to explore the radiosensitizing effects of parecoxib in human HCT116 and HT29 CRC cells. Results: Parecoxib sensitized CRC cells to radiation in vitro with a sensitivity enhancement ratio of 1.32 for HCT116 cells and 1.15 for HT29 cells at a surviving fraction of 0.37. This effect was partially attributable to enhanced apoptosis induction by parecoxib combined with radiation, as illustrated using an in vitro apoptosis assays. Parecoxib augmented the tumor response of HCT116 xenografts to radiation, achieving growth delay more than 20 days and an enhancement factor of 1.53. In accordance with the in vitro results, parecoxib combined with radiation resulted in less proliferation and more apoptosis in tumors than radiation alone. Radiation monotherapy decreased microvessel density (MVD) and microvessel intensity (MVI), but increased the hypoxia level in xenografts. Parecoxib did not affect MVD, but it increased MVI and attenuated hypoxia. Conclusions: Parecoxib can effectively enhance radiation sensitivity in CRC cells through direct effects on tumor cells and indirect effects on tumor vasculature.
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Xiong Wei,Xiaobin Liu,Bing Guo,Shen Yan,Wenli Zhang 보안공학연구지원센터 2016 International Journal of Smart Home Vol.10 No.3
As embedded devices prevail in daily life, high energy consumption caused by embedded software caught academic attentions. Multifarious testing and predicting methods are developed accordingly. This paper proposes a model about energy consumption of embedded device based on analysis of embedded software structure and support vector machine regression. The nonlinear relationship between energy consumption and software structure is revealed. The research finds software structure is determined by features like number of components, complexity of component interface, component coupling, and path length. These features are qualified and modeled by using support vector machine regression and energy consumption is predicted based on this model. The experiments results confirm the proposed model.
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Simultaneous variable selection and parametric estimation for quantile regression
Wei Xiong,Maozai Tian 한국통계학회 2015 Journal of the Korean Statistical Society Vol.44 No.1
In this paper, variable selection techniques in the linear quantile regression modelare mainly considered. Based on the penalized quantile regression model, a one-stepprocedure that can simultaneously perform variable selection and coefficient estimationis proposed. The proposed procedure has three distinctive features: (1) By consideringquantile regression, the set of relevant variables can vary across quantiles, thus makingit more flexible to model heterogeneous data; (2) The one-step estimator has niceproperties in both theory and practice. By applying SCAD penalty (Fan and Li, 2001)and Adaptive-LASSO penalty (Zou, 2006), we establish the oracle property for the sparsequantile regression under mild conditions. Computationally, the one-step estimator is fast,dramatically reducing the computation cost; (3) We suggest a BIC-like tuning parameterselector for the penalized quantile regression and demonstrate the consistency of thiscriterion. That is to say the true model can be identified consistently based on the BIC-likecriterion, making our one-step estimator more reliable practically. Monte Carlo simulationstudies are conducted to examine the finite-sample performance of this procedure. Finally,we conclude with a real data analysis. The results are promising.
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Wei Xiong,Guijun Yang,양태현,Shantang Liu,정용주 대한화학회 2017 Bulletin of the Korean Chemical Society Vol.38 No.3
Hierarchical carbon foams (HCFs) with micro-, meso-, and macropores were successfully synthesized via a two-step process: (1) polymerization in oil-in-water (O/W) emulsions without any hard templates and (2) carbonization at 850°C. With the aim of both enhancing the stability of the emulsion and forming a micro- and mesoporous structure during the carbonization process, potassium citrate was introduced in an aqueous solution of resorcinol and formaldehyde. A series of HCFs were fabricated by changing the mass ratio of potassium citrate to total carbon sources from 0.25 to 1.5. The effect of potassium citrate on the porous structure of HCFs was investigated through nitrogen sorption tests. The prepared HCFs exhibited well-developed porous structures of micro-, meso- and macropores and high surface areas. The structural characteristics of the HCFs, including pore size distribution, surface area, and porosity, were significantly dependent on the amount of potassium citrate. It was concluded that potassium citrate greatly contributed to the formation of carbon foams with nano-sized pore structures and high porosity. Interestingly, it was found that when the mass ratio of potassium citrate to total carbon sources was 0.5, the HCFs showed the highest specific surface area (~1360 m2/g). Furthermore, the capacitive performances of the HCFs were evaluated in a 6.0 M KOH aqueous solution using typical electrochemical methods such as cyclic voltammetry and galvanostatic charge/discharge tests. The capacitance of the HCFs tended to increase with the increase in surface area. In particular, the HCFs with the highest surface area also exhibited excellent electrochemical properties (high capacitance of 224 F/g at 1.0 A/g, high rate capability of 191 F/g at 10.0 A/g). These features may be attributed to both the resulting interconnected pore structure that is easily accessible to ions and the high surface area. We believe that this synthesis strategy can be easily extended to the preparation of hierarchical porous carbon materials with a desirable pore structure by tuning the organic monomer.
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Cancer Registration in the Peoples Republic of China
Wei, Kuang-Rong,Chen, Wan-Qing,Zhang, Si-Wei,Liang, Zhi-Heng,Zheng, Rong-Shou,Ou, Zhi-Xiong Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.8
The current situation of cancer registration in China was systematically reviewed. So far, cancer registration in China has been making a great progress in the following aspects: the number of cancer registries and covered population have increased dramatically; a registration network has been established and completed gradually; regulations and rules improved remarkably; more attention is being paid by every level of government; a lot of registration software has been created and financial support ensured. However, we are still facing some problems and challenges, such as no stable groups of registrars, shortage of training opportunities, poor data quality, insufficient utilization and lack of multidisciplinary mechanisms, so that the cancer registration system still needs to be enhanced and improved. Along with the development of economy, science and information technology, methods and patterns of cancer registration is changing. It is to be expected that cancer registration will be automatic, nationwide and integrated with community healthcare in the near future.
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Cryptochrome 1 functions as nuclear co-receptor independence of circadian clock
Wei Xiong,Tao Cai 한국유전학회 2016 Genes & Genomics Vol.38 No.4
Cryptochrome 1 (CRY1) is well known as a circadian clock repressor. Recent studies have shown that it could intimately associate with nuclear receptors and either activate or inhibit its targets at the transcriptional level. In the present study, we applied publicly available transcriptional factors Chromatin Immunoprecipitation coupled high throughput sequencing data to prove that CRY1 associates with various nuclear receptors at the genomewide level, which is independent of its canonical role as a circadian clock repressor. Furthermore, we have also shown that CRY1 is a confident co-receptor of retinoid X receptor, alpha (RXRa). We have also further shown that CRY1 could directly interact with RXRa. The interaction was regulated by retinoic acid treatment in a dose-dependent manner. In addition, CRY activator could antagonized RA-medicated PCK1 and G6PC expression, which in turn antagonize glucose production. Our findings indicate that CRYs could be potential targets in relieving side effects of RA-oriented treatment for diseases such as leukemia, acne, and psoriasis.
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Xiong Wei-hao,Zheng Li-yun,Yan Xian-mei 한국분말야금학회 2006 한국분말야금학회 학술대회논문집 Vol.2006 No.1
Sintered Ti(C,N)-based cermets were treated with hot isostatic pressing (HIP) at different nitrogen pressures. The tribological properties of the treated cermets have been evaluated. The results show that a hard near-surface area rich in TiN formed after HIP treatment. The cermets treated at higher pressure had a relatively lower friction coefficient and specific wear rate. In all cases the microhardness of treated cermets is higher than that without HIP natridation. The wear mechanisms of cermets were hard particle flaking-off and ploughing. It was also found that the HIP natridation is well-suited for improving the tribological properties of cermets.
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