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Circ_0068655 Promotes Cardiomyocyte Apoptosis via miR-498/PAWR Axis
Chai Qiaoying,Zheng Mingqi,Wang Le,Wei Mei,Yin Yajuan,Ma Fangfang,Li Xinping,Zhang Haijun,Liu Gang 한국조직공학과 재생의학회 2020 조직공학과 재생의학 Vol.17 No.5
Background: The cardiomyocyte apoptosis is considered as one of major contributions to cardiac remodeling after myocardial infarction (MI). Numerous studies find that circular RNAs (circRNAs) play pivotal roles in a variety of biological functions. However, the role of circ_0068655 in MI and human induced pluripotent stem-derived cardiomyocytes (HCMs) remains unknown. Methods: The expression of circ_0068655, miR-498, and PRKC apoptosis WT1 regulator (PAWR) in human MI heart tissues and hypoxia subjected HCMs was evaluated with qRT-PCR and Western blot. The effects of circ_0068655 on hypoxia-induced apoptotic death and cell migration in HCMs were evaluated with qRT-PCR, cell viability, cell death ELISA (POD), and Caspase-3 activity assay, and Trans-well assay, respectively. Furthermore, luciferase assay, qRT-PCR, biotin-labeled miRNA pulldown assay, and Western blot were employed in the functional studies. Results: We found that the expression of circ_0068655 and PAWR was enhanced in MI patients and hypoxia subjected HCMs; by contrast, the expression of miR-498 decreased. Inhibited expression of circ_0068655 in HMCs counteracted hypoxia-induced apoptotic death and impaired cell migration, in sharp contrast to circ_0068655 knockdown. We identified that circ_0068655 sponged an endogenous miR-498 to sequester and inhibit its activity, leading to the increased PAWR expression. Conclusions: Our findings reveal that the expression of circ_0068655 can promote cardiomyocyte apoptosis through the modulation of miR-498-PAWR axis in vitro, which highlights the diagnostic and therapeutic value of circ_0068655 in patients with MI.
Hao Wang,Qian Yuan,Linjiang Chai,Ke Zhao,Ning Guo,Jun Xiao,Xing Yin,Bin Tang,Yuqiong Li,Shaoyu Qiu 한국원자력학회 2022 Nuclear Engineering and Technology Vol.54 No.6
A typical ferritic/martensitic (F/M) steel sheet was subjected to pulsed laser surface remelting (LSR) andcorrosion test in lead-bismuth eutectic (LBE) at 550 C. There present two modification zones withdistinct microstructures in the LSRed specimen: (1) remelted zone (RZ) consisting of both bulk d-ferritegrains and martensitic plates and (2) heat-affected zone (HAZ) below the RZ, mainly composed ofmartensitic plates and high-density precipitates. Martensitic transformation occurs in both the RZ andthe HAZ with the Kurdjumov-Sachs and Nishiyama-Wassermann orientation relationships followedconcurrently, resulting in scattered orientations and specific misorientation characteristics. Hardnessesof the RZ and the HAZ are 364 ± 7 HV and 451 ± 15 HV, respectively, considerably higher than that of thematrix (267 ± 3 HV). In oxygen-saturated and oxygen-depleted LBE, thicknesses of oxide layers developed on both the as-received and the LSRed specimens increase with prolonging corrosion time (oxidelayers always thinner under the oxygen-depleted condition). The corrosion resistance of the LSRed F/Msteel in oxygen-saturated LBE is improved, which can be attributed to the grain-refinement acceleratedformation of dense FeeCr spinel. In oxygen-depleted LBE, the growth of oxide layers is very low withboth types of specimens showing similar corrosion resistance
Khan, Sajid Ullah,Chai, Wang Yin,See, Chai Soo,Khan, Amjad Korea Information Processing Society 2016 Journal of information processing systems Vol.12 No.1
To resolve the problems of Poisson/impulse noise, blurriness, and sharpness in degraded X-ray images, a novel and efficient enhancement algorithm based on X-ray image fusion using a discrete wavelet transform is proposed in this paper. The proposed algorithm consists of two basics. First, it applies the techniques of boundary division to detect Poisson and impulse noise corrupted pixels and then uses the Wiener filter approach to restore those corrupted pixels. Second, it applies the sharpening technique to the same degraded X-ray image. Thus, it has two source X-ray images, which individually preserve the enhancement effects. The details and approximations of these sources X-ray images are fused via different fusion rules in the wavelet domain. The results of the experiment show that the proposed algorithm successfully combines the merits of the Wiener filter and sharpening and achieves a significant proficiency in the enhancement of degraded X-ray images exhibiting Poisson noise, blurriness, and edge details.
( Sajid Ullah Khan ),( Wang Yin Chai ),( Chai Soo See ),( Amjad Khan ) 한국정보처리학회 2016 Journal of information processing systems Vol.12 No.1
To resolve the problems of Poisson/impulse noise, blurriness, and sharpness in degraded X-ray images, a novel and efficient enhancement algorithm based on X-ray image fusion using a discrete wavelet transform is proposed in this paper. The proposed algorithm consists of two basics. First, it applies the techniques of boundary division to detect Poisson and impulse noise corrupted pixels and then uses the Wiener filter approach to restore those corrupted pixels. Second, it applies the sharpening technique to the same degraded X-ray image. Thus, it has two source X-ray images, which individually preserve the enhancement effects. The details and approximations of these sources X-ray images are fused via different fusion rules in the wavelet domain. The results of the experiment show that the proposed algorithm successfully combines the merits of the Wiener filter and sharpening and achieves a significant proficiency in the enhancement of degraded X-ray images exhibiting Poisson noise, blurriness, and edge details.