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RISS 인기검색어
- 검색키워드
- 저자 : ( Tran Thien Quan Vu ) (검색결과 2 건)
- 무료
- 기관 내 무료
- 유료
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( Tran Thien Quan Vu ),( Diem Thu Pham ),( Quynh Mai Pham ) 대한결핵 및 호흡기학회 2020 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.128 No.-
Purpose This study aimed to describe the blood EOS levels in patients with these diseases and state of ICS prescription in groups of COPD patients according to the blood EOS cut - offs 100 and 300 cells/μL. Materials and Method This study was a retrospective descriptive cross - sectional study and a convenience sampling of outpatients aged ≥ 18 years, diagnosed with asthma (based on medical history, symptoms, smoking < 10 pack-years and positive reversibility test), COPD (based on symptoms, smoking > 10 pack-years, and post-bronchodilator FEV1/FVC < 0.70) or ACO (COPD (age > 35, smoking > 10 pack-years, post-bronchodilator FEV1/FVC < 0.70, and positive reversibility test with FEV1 increased > 400 miL and 15%) in University Medical Center in 2019 and had blood EOS tests. 333 asthma patients, 168 COPD patients and 102 ACO patients were included. Results Of 333 asthma patients, 143 (42.9%) were male, of 168 COPD patients 158 (94.0%) were male, of 102 ACO patients, 91 (89.2%) were male. Median age +/- IQR of asthma, COPD, ACO was 53 (39-65), 67 (62-73), 62 (54-68), respectively. Medians of blood EOS in asthma patients (2.9%; 249 cells/mL) and ACO patients (2.8%; 260 cells/mL) were significantly higher than in COPD patients (2.0%; 170 cells/mL). All three groups have mainly blood EOS levels of ≥ 100 cells/μL. The ratio of COPD patients with blood EOS < 100 cells/mL using ICS accounted for 35.6%. The ratio of COPD patients with blood EOS ≥ 300 cells/mL without ICS was 63.0%, of which 35.2% were group D patients. Conclusion This descriptive study of blood EOS levels in asthma, COPD and ACO patients is a cornerstone of further studies to find out the most appropriate EOS thresholds for diagnosis and treatment of these diseases in Vietnam.
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Lan Ngoc Vuong,Tu Hoang Kim Trinh,Tuan Diep Tran,Duy Le Pham,Vinh Nhu Nguyen,Quan Tran Thien Vu,Toan Duong Pham,Phong Hoai Nguyen,Minh Kieu Le,Diem Dinh Kieu Truong,Vu Anh Hoang,Nghia Huynh,Dat Quoc N 연세대학교의과대학 2024 Yonsei medical journal Vol.65 No.9
Purpose: Although some immune protection from close contact with individuals who have coronavirus disease 2019 (COVID-19) has been documented, there is limited data on the seroprevalence of antibodies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in individuals who were in lockdown with confirmed COVID-19 cases. This study investigated immunogenicity against SARS-CoV-2 in household members and people who lived near home-quarantined patients with COVID-19. Materials and Methods: This cross-sectional study was conducted during the community-based care that took place during lockdowns in District 10, Ho Chi Minh City, Vietnam from July to September 2021. SARS-CoV-2 antibody levels were determined in index cases of COVID-19, household contacts, and a no-contact group from the same area. Results: A total of 770 participants were included (355 index cases, 103 household contacts, and 312 no contacts). All index cases were unvaccinated, but >90% of individuals in the household and no-contact groups had received ≥1 vaccine dose. SARS-CoV-2 neutralizing antibodies (Nabs) were present in >77% of unvaccinated index cases versus 64%/65.4% in the household/no-contact groups (p=0.001). Antibody concentrations in unvaccinated index cases were significantly higher than those in household contacts and no contacts, with no difference between the latter groups. In all cases, antibody levels declined markedly ≥6 weeks after infection, and failed to persist beyond this time in the household and no-contact groups. Conclusion: Community-based care may have helped to create community immunogenicity, but Nabs did not persist, highlighting a need for vaccination for all individuals before, or from 6 weeks after, infection with SARS-CoV-2.
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