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The mundanity of Olympic housing: Norwegian athletes at the 2010 Winter Games
( Elsa Kristiansen ),( Svein S Andersen ),( Dag Vidar Hanstad ) 한국스포츠정책과학원(구 한국스포츠개발원) 2013 International Journal of Applied Sports Sciences Vol.25 No.2
National teams face organizational challenges when planning and preparing for Olympic accommodation. In Norway such efforts are coordinated by the Olympic Top Sport Organization, Olympiatoppen. The ability to deal systematically with the many mundane factors in preparations and competitions is crucial, for example minor and mundane issues related to housing conditions may easily impact athletes` ability to perform. When discussing perceptions of stressors related to accommodations with ten Norwegian winter Olympians from the 2010 Vancouver Olympic Winter Games (OWG), they identified four areas of concern that may be central in comprehensive planning and preparation: accommodation and specific individual needs, the quality of recreation and food, managing security issues, and the regulation of press meetings. The most satisfied athletes belonged to sports where leaders took active part in discussions and spent time on details that would give the team an advantage like single room for clear medal candidates, Norwegian chefs, bringing their usual support personnel, extra recreational activities etc. Others were not that satisfied and felt that their needs (or sport) were not considered important enough. In conclusion, the Norwegian preparations for the 2010 OWG reflected a more conscious approach to quality control than previously, and even more important, the athletes felt that they had a say in the decision-making.
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Erta Kalanxhi,Karianne Risberg,Imon S. Barua,Svein Dueland,Stein Waagene,Solveig Norheim Andersen,Solveig J. Pettersen,Jessica M. Lindvall,Kathrine Røe Redalen,Kjersti Flatmark,Anne Hansen Ree 대한암학회 2017 Cancer Research and Treatment Vol.49 No.2
Purpose When integrating molecularly targeted compounds in radiotherapy, synergistic effects of the systemic agent and radiation may extend the limits of patient tolerance, increasing the demand for understanding the pathophysiological mechanisms of treatment toxicity. In this Pelvic Radiation and Vorinostat (PRAVO) study, we investigated mechanisms of adverse effects in response to the histone deacetylase (HDAC) inhibitor vorinostat (suberoylanilide hydroxamic acid, SAHA) when administered as a potential radiosensitiser. Materials and Methods This phase I study for advanced gastrointestinal carcinoma was conducted in sequential patient cohorts exposed to escalating doses of vorinostat combined with standard-fractionated palliative radiotherapy to pelvic target volumes. Gene expression microarray analysis of the study patient peripheral blood mononuclear cells (PBMC) was followed by functional validation in cultured cell lines and mice treated with SAHA. Results PBMC transcriptional responses to vorinostat, including induction of apoptosis, were confined to the patient cohort reporting dose-limiting intestinal toxicities. At relevant SAHA concentrations, apoptotic features (annexin V staining and caspase 3/7 activation, but not poly-(ADP-ribose)-polymerase cleavage) were observed in cultured intestinal epithelial cells. Moreover, SAHA-treated mice displayed significant weight loss. Conclusion The PRAVO study design implemented a strategy to explore treatment toxicity caused by an HDAC inhibitor when combined with radiotherapy and enabled the identification of apoptosis as a potential mechanism responsible for the dose-limiting effects of vorinostat. To the best of our knowledge, this is the first report deciphering mechanisms of normal tissue adverse effects in response to an HDAC inhibitor within a combined-modality treatment regimen.
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Marit H. Stafsnes,Kjell D Josefsen,Trond E. Ellingsen,Geir Kildahl-Andersen,Svein Valla,Per Bruheim 한국미생물학회 2010 The journal of microbiology Vol.48 No.1
Microbial culture collections are important resources for isolation of natural compounds with novel properties. In this study, a culture collection of around 1,500 pigmented heterotrophic bacteria was established. The bacteria were isolated from the sea surface microlayer at different sampling sites along the mid-part of the Norwegian coast. The bacterial isolates produced pigments of various coloration (e.g. golden,yellow, red, pink and orange). Methanol extracts of sixteen isolates were characterized with LC-Diodearray-TOF mass spectrometry analysis. The number of pigments per isolate varied considerably, and a tentative identification of the pigments was performed based on UV-absorbance profile and molecular formula assignation based on the accurate mass determination. The LC-MS analyses revealed that most of the pigments probably were carotenoids. Furthermore, we developed a high throughput LC-MS method for characterization and screening of a larger sub-fraction (300 isolates) of the culture collection. The aim was to screen and identify bacterial isolates producing carotenoids that absorb light in the UVA-Blue light. Six of the bacterial strains were selected for detailed investigation, including 16s rRNA sequencing, preparative HPLC for purification of major carotenoids and subsequent structural elucidation with NMR. Among the identified carotenoids were zeaxanthin, nostoxanthin and sarcinaxanthin, some with novel glycosylation patterns.
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