http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Suppression of mast-cell-mediated allergic inflammation by Lindera obtusiloba.
Suh, Won Mo,Park, Seung-Bin,Lee, Soyoung,Kim, Hui-Hun,Suk, Kyoungho,Son, Jun-Ho,Kwon, Taeg Kyu,Choi, Hyun Gyu,Lee, Seung-Ho,Kim, Sang-Hyun The Society 2011 Experimental biology and medicine Vol.236 No.2
<P>Allergic disease is a consequence of exposure to normally innocuous substances that elicit the activation of mast cells. Mast-cell-mediated allergic response is involved in many diseases such as anaphylaxis, allergic rhinitis, asthma and atopic dermatitis. The discovery of drugs for the treatment of allergic disease is an important subject in human health. In this study, we investigated the effect of Lindera obtusiloba water extract (LOWE) on the mast-cell-mediated allergic inflammation and possible mechanism of action using in vitro and in vivo models. LOWE reduced histamine release from various types of mast cells activated by immunoglobulin E (IgE) or phorbol 12-myristate 13-acetate and calcium ionophore A23187 (PMACI). The inhibitory effect of LOWE on histamine release was mediated by calcium signal. LOWE decreased the PMACI-stimulated gene expression of proinflammatory cytokines such as tumor necrosis factor-관 and interleukin-6 in human mast cells. The inhibitory effect of LOWE on the proinflammatory cytokines was nuclear factor (NF)-관B dependent. In addition, LOWE suppressed compound 48/80-induced systemic allergic reaction and serum histamine release in mice and IgE-mediated local allergic reactions. Our results indicate that LOWE inhibits mast-cell-derived allergic inflammation and involvement of calcium, histamine, proinflammatory cytokines and NF-관B in these effects.</P>
( Suk-won Suh ),( Seung Eun Lee ),( Yoo Shin Choi ) 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1
Aims: In cirrhotic liver, major hepatic resection may cause a fatal clinical course that it is still a concern. Erythropoietin (EPO) has been known to have protective effect and stimulator of liver regeneration in previous studies. This study aims to investigate the effect of EPO after major hepatic resection in cirrhotic rat models. Methods: Cirrhotic liver was induced by an intraperitoneal injection of TAA in seventy Lewis rats. Two groups with (n=36) and without (n=36) EPO (1 IU/g, every other day, 5 times before operation) underwent major hepatectomy (left and a half of median lobes) and biochemical, histopathological and immunohistochemical parameters and overall survival were compared. Results: EPO led to significant decrement of aspartate aminotransferase and alanine aminotransferase and interleukin (IL)-1β expression at 48 hr after surgical resection. With EPO, hepatocyte growth factor and vascular endothelial growth factor expression at 1hr and IL-6 expression at 24 hr were significantly increased and Ki-67 was also significantly increased during 120 hr after surgical resection. Overall survival was significantly improved among EPO-treated rats (P = 0.034). Conclusions: Preoperative EPO treatment has protective effect and stimulates liver regeneration which leads to improvement of overall survival after surgical resection in cirrhotic rat models.
Won-Tae Hwang,Eun-Han Kim,Kyung-Suk Suh,Hyo-Jeon Jeong,Moon-Hee Han 한국방사성폐기물학회 2004 방사성폐기물학회지 Vol.2 No.3
방사성물질의 대기 누출 사고시 환경에서 핵종 거동을 모사하는 동적 섭식경로모델 DYNACON을 개선하여, 가축 (육우)의 공기 흡입과 토양 섭취가 육류 (쇠고기)의 방사능 오염에 미치는 영향을 고찰하였다. 이들 두 오염경로는 누출이 육우의 비방목 기간에 일어나는 경우에 육류의 오염에 있어서 결코 무시될 수 없는 경로라는 사실을 확인하였다. 특히 누출 후 대부분 기간에 걸쳐 토양 섭취에 의한 육류의 오염 영향이 공기 흡입에 의한 영향에 비해 우세하였다. 누출 기간동안 강우는 토양 섭취에 의한 육류의 오염에 중요한 요소로 작용하였으며, 이러한 현상은 단반감기 핵종인 보다 장반감기 핵종인 의 경우에 보다 뚜렷하였다. 이전에 수행된 우유에 대한 분석 결과와 비교하여 공기 흡입과 토양 섭취는 육류에 대해 보다 중요한 오염경로로 나타났는데, 이는 상대적으로 육류에서 핵종의 긴 생물학적 반감기 때문이다. 방목기간에 방사성물질이 대기로 누출되는 경우 누출 기간동안 강우의 유무에 관계없이 목초 섭취에 의한 오염 영향이 지배적이었으며, 결과적으로 토양 섭취와 공기 흡입에 의한 오염 영향은 우유의 경우와 마찬가지로 무시할 수 있는 수준이었다. The contaminative influence of beef due to the inhalation of air and the ingestion of soil of livestock, both of which are dealt with as minor contaminative pathways in most radioecological models but may not be neglected, was comprehensively investigated with the improvement of the Korean food chain model DYNACON. As the results, it was found that both pathways can not be neglected at all in the contamination of beef in the case of an accidental release during the non-grazing period of livestock. The ingestion of soil was more influential in the contamination of beef than the inhalation of air over most time following an release. If precipitation is encountered during an accidental release, contaminative influence due to the ingestion of soil was far greater compared with the cases of no precipitation. This fact was more distinct for a long-lived radionuclide than a short-lived radionuclide (elemental iodine). Compared with the results for milk performed prior to this study, the contaminative pathways due to the inhalation of air and the ingestion of soil were more important in beef because of longer biological half-lives. On the other hand, in the case of an accidental release during the grazing period of livestock, radioactive contamination due to the ingestion of pasture was dominant irrespective of the existence of precipitation during an accidental release. It means that contaminative influence due to the inhalation of air and the ingestion of soil is negligible, like the cases of milk.
Optimal Formation of UAV Swarm for TDOA-Based Passive Target Tracking
Suh Ui-Suk,Han Seul-Ki,Ra Won-Sang 대한전기학회 2022 Journal of Electrical Engineering & Technology Vol.17 No.1
An analytic solution to the optimal formation problem of an unmanned aerial vehicle (UAV) swarm is newly proposed for maximizing the perfomrance of passive target tracking. Most previous techniques could not handle this problem effi - ciently because they have had diffi culties in defi ning the performance index of a nonlinear target tracking fi lter in closed form. To overcome this limitation, the passive target tracking problem is investigated within the framework of the linear non-conservative robust Kalman fi lter (NCRKF) theory. Accommodating the merit of the suggested linear target tracking fi lter structure, its performance measure can be analytically expressed in terms of the UAV formation as well as the sensor accuracy. Therefore, it is easy to determine the optimal UAV formation by maximizing the target tracking performance in the worst case. In addition, our approach is very practical because it considers the estimation error characteristics of the actual passive target tracking fi lter and the communication range among UAVs in determining the optimal UAV formation. Through the simulations, the eff ectiveness of the proposed scheme is validated.
( Suk-won Suh ),( Youngrok Choi ),( Ho-seong Han ),( Yoo-seok Yoon ),( Jai Young Cho ),( Yoo Shin Choi ),( Seung Eun Lee ),( Jaehong Jeong ) 대한간학회 2018 춘·추계 학술대회 (KASL) Vol.2018 No.1
Aims: Although increment application of single-incision laparoscopic cholecystectomy (SILC), it had technical difficulties of physical disturbance and unstable surgical view through the small incision, therefore, we introduced solo single-incision LC (S-SILC) using laparoscopic scope holder, a simple, fixed and easily handled by a surgeon. Methods: A comparison of S-SILC (group A, n=566) and conventional three-incision laparoscopic cholecystectomy (C-TILC, group B, n=874) from January, 2013 to December, 2016 at multicenter was performed. Baseline characteristics, perioperative outcomes including complications were compared. Results: Mean operative time was not significantly different between two groups (P = 0.176), however, S-SILC had more intraoperative GB perforation, especially in initial period (17.0% vs. 2.3%, P < 0.001) and increased usage of additional port (3.2% vs. 0.5%, P < 0.001) and shorter hospital stay (3.3 ± 1.7 vs. 1.9 ± 2.7, P<0.001) than C-TILC. There was no significant difference of major postoperative complications between two groups (P = 0.909) and its identified risk factors were not operation type (P = 0.971), but mean age (P = 0.004) and upper abdominal operation history (P = 0.048). Conclusions: S-SILC is feasible and safe, but careful selection of surgical candidates is necessary, in initial period of S-SILC experience.