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RISS 인기검색어
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- 저자 : ( Sedat Yilmaz ) (검색결과 2 건)
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The presence of MEFV gene mutations in patients with primary osteoarthritis who require surgery
( Sedat Yilmaz ),( Hakan Erdem ),( Servet Tunay ),( Deniz Torun ),( Halil Genc ),( Yusuf Tunca ),( Omer Karadag ),( Ismail Simsek ),( Muhterem Bahce ),( Salih Pay ),( Ayhan Dinc ) 대한내과학회 2013 The Korean Journal of Internal Medicine Vol.28 No.5
Background/Aims: Chronic arthritis of familial Mediterranean fever (FMF) involves weight-bearing joints and can occur in patients without a history of acute attack. Our aim was to investigate a possible causal relationship between FMF and osteoarthritis in a population in which FMF is quite common. Methods: Patients with late stage primary osteoarthritis were enrolled, and five MEFV gene mutations were investigated. The frequency of MEFV gene mutations was compared among patients with osteoarthritis and a previous healthy group from our center. Results: One hundred patients with primary osteoarthritis and 100 healthy controls were studied. The frequency of MEFV gene mutations was significantly lower in the osteoarthritis group (9% vs. 19%). M694V was the most frequent mutation (5%) in the osteoarthritis group, whereas in the control group, E148Q was the most common (16%). In subgroup analyses, the mutation frequency of patients with hip osteoarthritis was not different from that of patients with knee osteoarthritis and controls (7.1%, 9.7%, and 19%, respectively). There were no differences among the three groups with respect to MEFV gene mutations other than E148Q (8.1% vs. 3.6%). E148Q was significantly lower in the osteoarthritis group than in the controls (16% vs. 1%), although the mutations did not differ between patients with knee osteoarthritis and controls. Conclusions: In a population with a high prevalence of MEFV gene mutations, we did not find an increased mutation rate in patients with primary osteoarthritis. Furthermore, we found that some mutations were significantly less frequent in patients with osteoarthritis. Although the number of patients studied was insufficient to claim that E148Q gene mutation protects against osteoarthritis, the potential of this gene merits further investigation.
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Anti-tank impact absorption with a reinforced concrete plate design
Berivan Yilmazer Polat,Sedat Savas,Alper Polat Techno-Press 2023 Advances in concrete construction Vol.15 No.4
Anti-tank weapons are among the infantry weapons used by the armies of many countries. Anti-tank rockets and explosives such as TNT, generally used for armour piercing, are also frequently used in terrorist attacks. These attacks damage the protection facilities built from reinforced concrete. Rockets or similar explosives' rapid speed and burst temperatures pierce reinforced concrete during strikes, resulting in casualties and damage to crucial strategic structures. This study aimed to devise an economic and applicable reinforced concrete plate that could absorb the impact of anti-tank rockets and Trinitrotoluene (TNT) type explosives. Therefore, 5 different samples, produced from C50 reinforced concrete and 150×150 cm in size, were formed by combining plates of different numbers and thicknesses. Also, a sample, which was a single thick plate, was prepared. In destructive testing, Rocket Propelled Grenade (RPG-7) was used as the anti-tank rocket launcher. As a result of this study, the impact damage was reduced with hollow concrete plate geometries, and recommendations were developed for complete prevention.
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