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Poster Session 1 : Isoproterenol modulates the expression of RGS2 in C6 rat glioma cells
( Sung Dae Kim ),( Hui Min Lee ),( Hye Jin Sung ),( Sun Kyu Park ),( Tae Wan Kim ),( Kil Soo Kim ),( Jae Chan Song ),( Seung Chun Park ),( Won Gi Min ),( Jae Youl Cho ),( Man Hee Rhee ) 생화학분자생물학회 2005 생화학분자생물학회 춘계학술발표논문집 Vol.2005 No.-
( Sung Soo Kim ),( Jae Won Lee ),( Yong Joon Choi ),( Sue Young Lee ),( Sang Soo Kang ),( Nam Ho Kim ),( Yong Soo Kwon ),( Hee Jae Lee ),( Wan Joo Chun ) 한국응용약물학회 2011 Biomolecules & Therapeutics(구 응용약물학회지) Vol.19 No.4
Aberrant activation of microglia has been reported to cause neuronal damages by releasing a variety of pro-infl ammatory cytokines. Besides where microglia become active, damages have been also observed in remote places, which is considered due to the migration of activated microglia. Therefore, an agent that could suppress abnormal activation of microglia and their subsequent migration might be valuable in activated microglia-related brain pathologies. The objective of the present study was to evaluate anti-infl ammatory effects of betulinic acid on lipopolysaccharide (LPS)-stimulated BV2 microglial cells. Pretreatment of betulinic acid signifi cantly attenuated LPS-induced NO production and protein expression of iNOS. Betulinic acid also signifi cantly suppressed LPS-induced release and expression of cytokines such as TNF-α and IL-1β. Furthermore, betulinic acid signifi cantly suppressed LPS-induced MMP-9 expression, which has been suggested to play an important role in the migration of activated microglia. In order to understand the possible mechanism by which betulinic acid suppresses LPS-induced cytokine production and migration of microglia, the role of NF-kB, a major pro-infl ammatory transcription factor, was examined. Betulinic acid signifi - cantly suppressed LPS-induced degradation of IKB, which retains NF-kB in the cytoplasm. Therefore, nuclear translocation of NF-kB upon LPS stimulation was signifi cantly suppressed with betulinic acid. Taken together, the present study for the fi rst time demonstrates that betulinic acid possesses anti-infl ammatory activity through the suppression of nuclear translocation of NF-kB in BV2 microglial cells.
Female Breast Cancer Incidence Among Asian and Western Populations: More Similar Than Expected
Sung, Hyuna,Rosenberg, Philip S.,Chen, Wan-Qing,Hartman, Mikael,Lim, Wei-yen,Chia, Kee Seng,Wai-Kong Mang, Oscar,Chiang, Chun-Ju,Kang, Daehee,Ngan, Roger Kai-Cheong,Tse, Lap Ah,Anderson, William F.,Ya U.S. Dept. of Health, Education, and Welfare, Publ 2015 Journal of the National Cancer Institute Vol.107 No.7
<P><B>Background:</B></P><P>Previous reports suggested that female breast cancer is associated with earlier ages at onset among Asian than Western populations. However, most studies utilized cross-sectional analyses that may be confounded by calendar-period and/or birth cohort effects. We, therefore, considered a longitudinal (forward-looking) approach adjusted for calendar-period changes and conditioned upon birth cohort.</P><P><B>Methods:</B></P><P>Invasive female breast cancer data (1988–2009) were obtained from cancer registries in China, Hong Kong, South Korea, Taiwan, Singapore, and the United States. Age-period-cohort models were used to extrapolate longitudinal age-specific incidence rates for the 1920, 1944, and 1970 birth cohorts.</P><P><B>Results:</B></P><P>Cross-sectional age-specific incidence rates rose continuously until age 80 years among US white women, but plateaued or decreased after age 50 years among Asian women. In contrast, longitudinal age-specific rates were proportional (similar) among all Asian countries and the United States with incidence rates rising continuously until age 80 years. The extrapolated estimates for the most recent cohorts in some Asian countries actually showed later ages at onset than in the United States. Additionally, over successive birth cohorts, the incidence rate ratios (IRRs) for the longitudinal curves converged (narrowed) between Asian and US white women.</P><P><B>Conclusions:</B></P><P>Similar longitudinal age-specific incidence rates along with converging IRRs indicate that the age effects for invasive breast cancer are more similar among Asian and Western populations than might be expected from a solely cross-sectional analysis. Indeed, the Asian breast cancer rates in recent generations are even surpassing the historically high rates in the United States, highlighting an urgent need for efficient prevention and treatment strategies among Asian populations.</P>
Volatile Organic Compound Specific Detection by Electrochemical Signals Using a Cell-Based Sensor
( Sang Gwi Chung ),( Jo Chun Kim ),( Chong Ho Park ),( Woong Shick Ahn ),( Yong Wan Kim ),( Jeong Woo Choi ) 한국미생물 · 생명공학회 2008 Journal of microbiology and biotechnology Vol.18 No.1
A cell-based in vitro exposure system was developed to determine whether oxidative stress plays a role in the cytotoxic effects of volatile organic compounds (VOCs) such as benzene, toluene, xylene, and chlorobenzene, using human epithelial HeLa cells. Thin films based on cysteineterminated synthetic oligopeptides were fabricated for immobilization of the HeLa cells on a gold (Au) substrate. In addition, an immobilized cell-based sensor was applied to the electrochemical detection of the VOCs. Layer formation and immobilization of the cells were investigated with surface plasmon resonance (SPR), cyclic voltammetry (CV), and electrochemical impedance spectroscopy (EIS). The adhered living cells were exposed to VOCs; this caused a change in the SPR angle and the VOC-specific electrochemical signal. In addition, VOC toxicity was found to correlate with the degree of nitric oxide (NO) generation and EIS. The primary reason for the marked increase in impedance was the change of aqueous electrolyte composition as a result of cell responses. The p53 and NF-κB downregulation were closely related to the magnitude of growth inhibition associated with increasing concentrations of each VOC. Therefore, the proposed cell immobilization method, using a self-assembly technique and VOC-specific electrochemical signals, can be applied to construct a cell microarray for onsite VOC monitoring.
Chun, Sungwoo,Son, Wonkyeong,Kim, Da Wan,Lee, Jihyun,Min, Hyeongho,Jung, Hachul,Kwon, Dahye,Kim, A-Hee,Kim, Young-Jin,Lim, Sang Kyoo,Pang, Changhyun,Choi, Changsoon American Chemical Society 2019 ACS APPLIED MATERIALS & INTERFACES Vol.11 No.18
<P>Wearable and skin-attachable electronics with portable/wearable and stretchable smart sensors are essential for health-care monitoring devices or systems. The property of adhesion to the skin in both dry and wet environments is strongly required for efficient monitoring of various human activities. We report here a facile, low-cost, scalable fabrication method for skin-adhesive graphene-coated fabric (GCF) sensors that are sensitive and respond fast to applied pressure and strain. With octopus-like patterns formed on the side of the GCF that touches the skin, the GCF adheres strongly to the skin in both dry and wet environments. Using these characteristics, we demonstrate efficient monitoring of a full range of human activities, including human physiological signals such as wrist pulse and electrocardiography (ECG), as well as body motions and speech vibrations. In particular, both measurements of ECG and wrist-bending motions were demonstrated even in wet conditions. Our approach has opened up a new possibility for wearable and skin-adherent electronic fabric sensors working even in wet environments for health-care monitoring and medical applications in vitro and in vivo.</P> [FIG OMISSION]</BR>
Safety and Feasibility of Laparoscopic Surgery for Small Bowel Obstruction
Sung Min Kim,Jun Ho Park,Byung Chun Kim,Byung Mo Kang,Jong Wan Kim,Jeong Yeon Kim 대한내시경복강경외과학회 2018 Journal of Minimally Invasive Surgery Vol.21 No.2
Purpose: Laparoscopic adhesiolysis is increasingly used to treat patients with small bowel obstruction (SBO), however, its safety of laparoscopic surgery(LS) with bowel resection in SBO is unclear. The purpose of the present study was to compare the perioperative outcomes of LS with those of open surgery (OS) for SBO and to evaluate the risk factors of 30-day postoperative morbidity and recurrence. Methods: We retrospectively reviewed medical records of patients who had been diagnosed with SBO and underwent surgery at four Hallym-University-affiliated hospitals between January 2013 and December 2016. The rates of 30-day postoperative complications and recurrence were compared between groups using univariate and multivariate analysis. Propensity score matching was performed to compare the outcome. Results: A total of 117 patients with SBO were included in the present study, of which 86 underwent OS and 31 underwent LS. Time to water intake, time to soft diet, and postoperative hospital stay were significantly shorter in the LS group (p=0.002, 0.003, and 0.027, respectively). The complication (p=0.249) and recurrence rate (p=0.679) were similar between the two group. Propensity score matching analysis demonstrated that laparoscopic surgery showed quicker recovery and similar complication and recurrence rate. In multivariate analysis, LS was not associated with either complications (p=0.806) or recurrence (p=0.956). Conclusion: LS is associated with several perioperative advantages for the treatment of SBO without affecting the risk of 30-day postoperative complications or recurrence. Therefore LS can be a safe and feasible option for treating SBO.