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Sensitivity analysis of the influencing factors of slope stability based on LS-SVM
Xu, Juncai,Ren, Qingwen,Shen, Zhenzhong Techno-Press 2017 Geomechanics & engineering Vol.13 No.3
This study proposes a sensitivity analysis method for slope stability based on the least squares support vector machine (LS-SVM) to examine the influencing factors of slope stability. The method uses LS-SVM as an algorithm for machine learning. An appropriate training dataset is established according to the slope characteristics, and a testing dataset is designed orthogonally. Results of the testing data in the experiment design are calculated after training using the LS-SVM model. The sensitivity of the slope stability of each factor is examined via gray correlation analysis. The results are consistent with those of the traditional Bishop analysis and can be used as a reference for optimizing slope design.
Xu, Ping,Wei, Bingqing,Cao, Zeyuan,Zheng, Jie,Gong, Ke,Li, Faxue,Yu, Jianyong,Li, Qingwen,Lu, Weibang,Byun, Joon-Hyung,Kim, Byung-Sun,Yan, Yushan,Chou, Tsu-Wei American Chemical Society 2015 ACS NANO Vol.9 No.6
<P>While the emerging wire-shaped supercapacitors (WSS) have been demonstrated as promising energy storage devices to be implemented in smart textiles, challenges in achieving the combination of both high mechanical stretchability and excellent electrochemical performance still exist. Here, an asymmetric configuration is applied to the WSS, extending the potential window from 0.8 to 1.5 V, achieving tripled energy density and doubled power density compared to its asymmetric counterpart while accomplishing stretchability of up to 100% through the prestrainning-then-buckling approach. The stretchable asymmetric WSS constituted of MnO<SUB>2</SUB>/CNT hybrid fiber positive electrode, aerogel CNT fiber negative electrode and KOH-PVA electrolyte possesses a high specific capacitance of around 157.53 μF cm<SUP>–1</SUP> at 50 mV s<SUP>–1</SUP> and a high energy density varying from 17.26 to 46.59 nWh cm<SUP>–1</SUP> with the corresponding power density changing from 7.63 to 61.55 μW cm<SUP>–1</SUP>. Remarkably, a cyclic tensile strain of up to 100% exerts negligible effects on the electrochemical performance of the stretchable asymmetric WSS. Moreover, after 10 000 galvanostatic charge–discharge cycles, the specific capacitance retains over 99%, demonstrating a long cyclic stability.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/ancac3/2015/ancac3.2015.9.issue-6/acsnano.5b01244/production/images/medium/nn-2015-012442_0007.gif'></P>
( Wenting Ou ),( Lin Lin ),( Rihong Chen ),( Qingwen Xu ),( Caijin Zhou ) 대한소화기기능성질환·운동학회 2022 Gut and Liver Vol.16 No.6
Background/Aims: The increased mortality of gastric cancer (GC) is mainly attributed to the development of chemoresistance. Circular RNAs, as the novel type of biomarkers in GC, have attracted wide attention. The purpose of this study was to investigate the functional role of circ_0081143 in GC with doxorubicin (DR) resistance and its potential action mechanism. Methods: The expression of circ_0081143, miR-129-2-3p and YES proto-oncogene 1 (YES1) in GC tissues and cells was measured by quantitative real-time polymerase chain reaction. The half maximal inhibitory concentration value was calculated based on the MTT cell viability assay. Cell proliferation and apoptosis were monitored by MTT and flow cytometry assays. Transwell assays were employed to check cell migration and invasion. The protein levels of YES1 and apoptosis-related proteins were detected by western blotting. The interaction between miR-129-2-3p and circ_0081143 or YES1 was verified by dual-luciferase reporter and pull-down assays. A tumorigenicity assay was conducted to verify the role of circ_0081143 in vivo. Results: Circ_0081143 was highly expressed in DR-resistant GC tumor tissues and cells. Depletion of circ_0081143 reduced DR resistance and inhibited DR-resistant GC cell proliferation, migration and invasion. Circ_0081143 targeted miR-129-2-3p and inhibited the role of miR-129-2-3p. In addition, YES1 was a target of miR-129-2-3p, and its function was suppressed by miR-129-2-3p. Importantly, circ_0081143 positively modulated the expression of YES1 through mediating miR-129-2-3p. Circ_0081143 knockdown weakened the DR-resistant GC tumor growth in vivo. Conclusions: Circ_0081143 knockdown weakened DR resistance and blocked the development of DR-resistant GC by regulating the miR-129-2-3p/YES1 axis. Our data suggest that circ_0081143 is a promising target for the treatment of GC with DR resistance. (Gut Liver 2022;16:861-874)