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Lee, Jun-Ho,Shin, Eun-Joo,Jeong, Sang Min,Kim, Jong-Hoon,Lee, Byung-Hwan,Yoon, In-Soo,Lee, Joon-Hee,Choi, Sun-Hye,Lee, Sang-Mok,Lee, Phil Ho,Kim, Hyoung-Chun,Nah, Seung-Yeol Elsevier 2006 european journal of pharmacology Vol.536 No.1
<P><B>Abstract</B></P><P>We previously demonstrated that dextromethorphan (DM; 3-methoxy-17-methylmorphinan) analogs have neuroprotective effects, and a recent report showed that DM reduces the adverse effects of morphine and blocks α<SUB>3</SUB>β<SUB>4</SUB> nicotinic acetylcholine receptors, a major target of anti-addictive agents. Here, we investigated the effects of DM, three of its analogs (DF, 3-methyl-17-methylmorphinan; AM, 3-allyloxy-17-methoxymorphian; and CM, 3-cyclopropyl-17-methoxymorphinan) and one of its metabolites (HM; 3-methoxymorphinan), on neuronal α<SUB>3</SUB>β<SUB>4</SUB> nicotinic acetylcholine receptor channel activity expressed in <I>Xenopus laevis</I> oocytes, using the two-microelectrode voltage clamp technique. We found that intraoocyte injection of neuronal α3 and β4 nicotinic acetylcholine receptor subunit cRNAs elicited an inward current (<I>I</I><SUB>ACh</SUB>) in the presence of acetylcholine. Co-treatment with DM, DF, AM, CM or HM inhibited <I>I</I><SUB>ACh</SUB> in a dose-dependent, voltage-independent and reversible manner. The IC<SUB>50</SUB> values for DM, DF, AM, CM and HM were 19.5±5.2, 15.8±4.5, 16.3±1.7, 10.1±2.8, and 13.5±4.0?μM, respectively. The order of potency for the inhibition of <I>I</I><SUB>ACh</SUB> was CM > HM > DF = AM > DM in oocytes expressing α3β4 nicotinic acetylcholine receptors. The inhibitions of (<I>I</I><SUB>ACh</SUB>) by DM, DF and HM, AM and CM were non-competitive. These results indicate that AM, CM and HM could be novel non-competitive agents regulating α<SUB>3</SUB>β<SUB>4</SUB> nicotinic acetylcholine receptor channel activity.</P>
운전조건 변화가 CO₂ 자동차 에어컨 시스템의 냉방성능에 미치는 영향에 대한 실험적 연구
이준경(Jun Kyoung Lee),이동혁(Dong Hyuk Lee),이헌균(Heon Kyun Lee),원종필(Jong Phil Won),최규정(Kyu Jung Choi),주필호(Phil Ho Ju),이원석(Won Suk Lee),최동기(Dong Ki Choi) 한국자동차공학회 2006 한국자동차공학회 춘 추계 학술대회 논문집 Vol.- No.-
This paper deals with the research for the effects of the operating parameters that could be used for a transcritical CO₂ mobile air-conditioning system on the cooling performance. It presents experimental results for the performance characteristics of a CO₂ mobile air conditioning system with various operating conditions such as different gas cooler inlet pressures and frontal air velocities/temperatures passing through the evaporator and the gas cooler. Experimental results show that the cooling capacity was more than 5㎾ and coefficient of performance (COP) was more than 2.1, also. Therefore, we checked that the mobile air-conditioning system using CO₂ has good cooling performance compared to that using HFC-134a.
CO₂ 자동차 에어컨 시스템의 최적 고압 설정 알고리즘 개발에 관한 연구
이준경(Jun Kyoung Lee),이동혁(Dong Hyuk Lee),이헌균(Heon Kyun Lee),원종필(Jong Phil Won),최규정(Kyu Jung Choi),주필호(Phil Ho Ju),이원석(Won Suk Lee),최동기(Dong Ki Choi) 한국자동차공학회 2006 한국자동차공학회 춘 추계 학술대회 논문집 Vol.- No.-
This paper deals with the development of optimum high pressure control algorithm for a transcritical CO₂ mobile air-conditioning system to achieve the maximum COP. The experiments were performed under idle and driving operating conditions. The experimental results demonstrated that the COP of the transcritical CO₂ system is a strong function of the gas cooling pressure. In other words, the COP was increased and then decreased with increase of the high pressure. Therefore the value of high pressure which has maximum COP could be selected. Furthermore, the strong(linear) relation between the optimum high pressure and the gas cooler outlet temperature was revealed, which suggests a simple controller of only one parameter for the transcritical CO₂ cycle.
( Jun Beom Park ),( Sun Sook Bae ),( Phil Woo Lee ),( Won Lee ),( Yoon Hee Park ),( Hee Sung Kim ),( Kyoung Hwa Lee ),( In Soo Kim ) 한국조직공학·재생의학회 2012 조직공학과 재생의학 Vol.9 No.4
There is increasing interest in the therapeutic potential of stem cells because stem cells are promising candidates for the regeneration of tissue and treatment of diseases. Increasing evidence supports, multipotent stem cells may be obtained postnatally in different organs and tissues including bone marrow, synovium, adipose tissue, muscle and dental pulp. To determine a suitable cell source, the stem cells derived from periosteum and bone marrow of jaw bone(mandible) and long bone(tibia) were compared using rabbit models (JPO: periosteum from jaw-bone, JBM: bone marrow from jaw-bone, LPO: periosteum from long-bone, and LBM: bone marrow from long-bone). This study evaluated the proliferation and multilineage differentiation of the cells and clearly showed that expansion ability of JPO was higher than that of bone marrow derived cells. Comparisons of four different stem cells indicated that JPO group is the highest estrogenic potential. Moreover, this study has demonstrated that JPO, JBM and LBM are superior in terms of osteogensis and JPO, LPO and LBM are superior in terms of chondrogensis. Collectively, stem cells derived from jaw bone periosteium revealed highest osteogenic properties with relatively low morbidity with higher availability. Thus, it can be suggested that that periosteum from the jaw bone may be considered as optimal candidate for source of pluripotent stem cells with multi-germline potential with highest expansion ability and osteogenicity.
Lee, Phil Jun,Cho, Namki,Yoo, Hee Min,Chang, Sun-Young,Ko, Hyun-Jeong,Kim, Hong Pyo Korean Society of Food Science and Technology 2020 한국식품과학회지 Vol.52 No.3
To retain valuable resources, organisms adopt several strategies including coprophagy. Cells covering the outer skin and internal digestive lumen are actively recycled to maintain their integrity. In present study, we suggested that the small intestine can consume dead cells in a manner similar to how it consumes protein from the diet. We examined the eluates from five segments of the mouse small intestine and cecum and 2 segments of the large intestine and small intestine tissue, and detected immunoreactivity with eukaryotic caveolin-1 and β-actin antibodies only in the cecum and 2 segments from the large intestine. Bacterial agitation of the mouse intestine with Shigella disrupted the architecture and absorptive function of the small intestine. Small intestine eluates were immunoreactive with murine caveolin-1 and contained heme as determined by dot blot analysis. We concluded that the body conserves resources in the small intestine by disposing of and recycling shedded cells.
( Phil Jun Lee ),( Chau Ha Pham ),( Nguyen Thi Thanh Thuy ),( Hye-jin Park ),( Sung Hoon Lee ),( Hee Min Yoo ),( Namki Cho ) 한국미생물생명공학회(구 한국산업미생물학회) 2021 Journal of microbiology and biotechnology Vol.31 No.2
This study aimed to investigate the neuroprotective effects of 1-methoxylespeflorin G11 (MLG), a pterocarpan, against glutamate-induced neurotoxicity in neuronal HT22 hippocampal cells. The protective effects of MLG were evaluated using MTT assay and microscopic analysis. The extent of apoptosis was studied using flow cytometric analysis performed on the damaged cells probed with annexin V/propidium iodide. Moreover, mitochondrial reactive oxygen species (ROS) were assessed using flow cytometry through MitoSOXTM Red staining. To determine mitochondrial membrane potential, staining with tetramethylrhodamine and JC-1 was performed followed by flow cytometry. The results demonstrated that MLG attenuates glutamate-induced apoptosis in HT22 cells by inhibiting intracellular ROS generation and mitochondrial dysfunction. Additionally, MLG prevented glutamate-induced apoptotic pathway in HT22 cells through upregulation of Bcl-2 and downregulation of cleaved PARP-1, AIF, and phosphorylated MAPK cascades. In addition, MLG treatment induced HO-1 expression in HT22 cells. These results suggested that MLG exhibits neuroprotective effects against glutamate-induced neurotoxicity in neuronal HT22 cells by inhibiting oxidative stress and apoptosis.
Lee, Jun Nyung,Chun, So Young,Lee, Hyo-Jung,Jang, Yu-Jin,Choi, Seock Hwan,Kim, Dae Hwan,Oh, Se Heang,Song, Phil Hyun,Lee, Jin Ho,Kim, Jong Kun,Kwon, Tae Gyun The Korean Academy of Medical Sciences 2015 JOURNAL OF KOREAN MEDICAL SCIENCE Vol.30 No.12
<P>We conducted this study to investigate the synergistic effect of human urine-derived stem cells (USCs) and surface modified composite scaffold for bladder reconstruction in a rat model. The composite scaffold (Polycaprolactone/Pluronic F127/3 wt% bladder submucosa matrix) was fabricated using an immersion precipitation method, and heparin was immobilized on the surface via covalent conjugation. Basic fibroblast growth factor (bFGF) was loaded onto the heparin-immobilized scaffold by a simple dipping method. In maximal bladder capacity and compliance analysis at 8 weeks post operation, the USCs-scaffold<SUP>heparin-bFGF</SUP> group showed significant functional improvement (2.34 ± 0.25 mL and 55.09 ± 11.81 µL/cm H<SUB>2</SUB>O) compared to the other groups (2.60 ± 0.23 mL and 56.14 ± 9.00 µL/cm H<SUB>2</SUB>O for the control group, 1.46 ± 0.18 mL and 34.27 ± 4.42 µL/cm H<SUB>2</SUB>O for the partial cystectomy group, 1.76 ± 0.22 mL and 35.62 ± 6.69 µL/cm H<SUB>2</SUB>O for the scaffold group, and 1.92 ± 0.29 mL and 40.74 ± 7.88 µL/cm H<SUB>2</SUB>O for the scaffold<SUP>heparin-bFGF</SUP> group, respectively). In histological and immunohistochemical analysis, the USC-scaffold<SUP>heparin-bFGF</SUP> group showed pronounced, well-differentiated, and organized smooth muscle bundle formation, a multi-layered and pan-cytokeratin-positive urothelium, and high condensation of submucosal area. The USCs seeded scaffold<SUP>heparin-bFGF</SUP> exhibits significantly increased bladder capacity, compliance, regeneration of smooth muscle tissue, multi-layered urothelium, and condensed submucosa layers at the in vivo study.</P>
Jun, Eun Kyoung,Zhang, Qiankun,Yoon, Byung Sun,Moon, Jai-Hee,Lee, Gilju,Park, Gyuman,Kang, Phil Jun,Lee, Jung Han,Kim, Areee,You, Seungkwon Molecular Diversity Preservation International (MD 2014 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES Vol.15 No.1
<P>In a previous study, we isolated human amniotic fluid (AF)-derived mesenchymal stem cells (AF-MSCs) and utilized normoxic conditioned medium (AF-MSC-norCM) which has been shown to accelerate cutaneous wound healing. Because hypoxia enhances the wound healing function of mesenchymal stem cell-conditioned medium (MSC-CM), it is interesting to explore the mechanism responsible for the enhancement of wound healing function. In this work, hypoxia not only increased the proliferation of AF-MSCs but also maintained their constitutive characteristics (surface marker expression and differentiation potentials). Notably, more paracrine factors, VEGF and TGF-β1, were secreted into hypoxic conditioned medium from AF-MSCs (AF-MSC-hypoCM) compared to AF-MSC-norCM. Moreover, AF-MSC-hypoCM enhanced the proliferation and migration of human dermal fibroblasts <I>in vitro</I>, and wound closure in a skin injury model, as compared to AF-MSC-norCM. However, the enhancement of migration of fibroblasts accelerated by AF-MSC-hypoCM was inhibited by SB505124 and LY294002, inhibitors of TGF-β/SMAD2 and PI3K/AKT, suggesting that AF-MSC-hypoCM-enhanced wound healing is mediated by the activation of TGF-β/SMAD2 and PI3K/AKT. Therefore, AF-MSC-hypoCM enhances wound healing through the increase of hypoxia-induced paracrine factors via activation of TGF-β/SMAD2 and PI3K/AKT pathways.</P>
Phil Jun Lee,Namki Cho,Hee Min Yoo,Sun-Young Chang,고현정,Hong Pyo Kim 한국식품과학회 2020 한국식품과학회지 Vol.52 No.3
To retain valuable resources, organisms adopt several strategies including coprophagy. Cells covering the outer skin and internal digestive lumen are actively recycled to maintain their integrity. In present study, we suggested that the small intestine can consume dead cells in a manner similar to how it consumes protein from the diet. We examined the eluates from five segments of the mouse small intestine and cecum and 2 segments of the large intestine and small intestine tissue, and detected immunoreactivity with eukaryotic caveolin-1 and β-actin antibodies only in the cecum and 2 segments from the large intestine. Bacterial agitation of the mouse intestine with Shigella disrupted the architecture and absorptive function of the small intestine. Small intestine eluates were immunoreactive with murine caveolin-1 and contained heme as determined by dot blot analysis. We concluded that the body conserves resources in the small intestine by disposing of and recycling shedded cells.
내시경적 점막절제술을 이용한 위의 전암병변 및 조기위암의 치료
정필호(Phil Ho Jung),이동기(Dong Ki Lee),이상철(Sang Cheol Lee),김준명(Jun Myeong Kim),백순구(Soon Koo Baik),김일희(Il Hoi Kim),최윤종(Yeun Jong Choi),조도연(Do Yeun Cho),이종인(Chong In Lee),권상옥(Sang Ok Kwon) 대한내과학회 1998 대한내과학회지 Vol.54 No.4
Objectives: Gastrectomy with lymph node dissection is the stare4rd treatment for early gastric cancer(EGC). However, patients who have high risks demand modifications in surgical treatment for EGC. Recently, endoscopic mucosal resection(EMR) has become accepted in many institutions as a treatment for cancerous mucosal lesions of the stomach. Thus we investigated the efficacy and safety of EMR prospectively in the patients with EGC who have high risks in surgery and those with premalignant lesions. Method: Twenty-five patients were treated with EMR, thirteen were EGC and twelve were premalignant lesions such as tubular adenoma, severe dysplasia. We used standard snare method and endoscopic mucosal resection using a band ligation kits(EMRI.), Resuts : The complete resection rate at the first step of EMR was 100%(13/12) in premalignant lesions, 76.9%(10/13) in EGC. Of three EGC resected incompletely at the first step, one patient was treated by surgery and two patients underwent the third step of EMR. The final complete resection rate was 92%(23/25) and it was 100%(12/12) in the premalignant lesions, 84.6%(11/13) in RX. We final complete resection rate in according to the methods was 100%(5/5) by standard snare method, 75%(6/8) by EMHL, As pathologic results, all cases of F were limited to the mucosa. No serious complications such as perforation, major bleeding were encountered. Conclusion: We consider that EMR is effective and safe in treatment of the patients with EGC who have high risks in surgery and those with prernalignant lesions.