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- 저자 : ( Minsol Kim ) (검색결과 4 건)
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Reimagining Universal Health Coverage: Safe and Affordable Surgery
Minsol Kim,Kee Bum Park,Sangchul Yoon 한국국제협력단 2021 국제개발협력 Vol.16 No.1
UN sustainable development goals (SDGs) and universal health coverage (UHC) are significant health goals the world needs to achieve. Despite concerted efforts to attain UHC, the world is still lagging. Compared to the sizable number of resources put into the treatment of well-known communicable diseases, such as HIV/AIDs, tuberculosis, and malaria, surgery is relatively underutilized despite its potential. Scaling up surgical interventions, however, is crucial since it can save many people’s lives and help avert the economic losses incurred due to diseases. Moreover, increased surgical capacity in low-to-middle-income countries (LMICs) could prove useful in overcoming pandemics, such as COVID-19. To upgrade the surgical capacity of the LMICs, it is essential to incorporate National Surgical, Obstetric, and Anaesthesia Plans (NSOAPs) into their national health policies. In this paper, the illustrative cases of two countries that adopted NSOAPs with a different model. Zambia and Pakistan, are examined. We conclude by giving recommendations to countries that are yet to adopt NSOAPs.
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Park Minsol,Choi Areum,Kim Seiki,Shim Wooyoung,Kim YooJin 한국세라믹학회 2022 한국세라믹학회지 Vol.59 No.6
Magnesium hydroxide sulfate hydrate (5 Mg(OH) 2·MgSO4·3H2O abbreviated 513MHSH) whiskers using for fiber reinforcements and fillers are synthesized via a reflux reaction by using MgO and H 2SO4 as reactants. In general, the 513MHSH whiskers have hydrophilic surface and heat resistant property with crystal water molecules. In this work, surface modification and SiO2 coating technique were employed for various application by coating with organic and silica layer on 513MHSH whisker surface. Also, SiO2 coating system is important for preventing aggregation and enhancing thermal stability [J Kor Ceram Soc 55:618, 2018; J Nanosci Nanotechnol 10:380, 2010]. Controlling pH value acts as important factor for establish one-step process that synthesis and surface modification/SiO2 coating process simultaneously to improve the efficiency in terms of the time and process. The morphology and phase of synthesized 513MHSH whiskers are characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM) and transmission electron microscopy (TEM). Surface modified whiskers were characterized by Fourier transform infrared spectroscopy (FTIR) and the thermal stability of SiO2 coated whiskers were evaluated by thermogravimetric analysis (TGA).
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Dong Hyun Jo,Su Hyun Lee,Minsol Jeon,Chang Sik Cho,Da-Eun Kim,김현경,김정훈 한국분자세포생물학회 2023 Molecules and cells Vol.46 No.11
Accumulation of pathogenic amyloid-β disrupts the tight junction of retinal pigment epithelium (RPE), one of its senescence-like structural alterations. In the clearance of amyloid-β, the autophagy-lysosome pathway plays the crucial role. In this context, mammalian target of rapamycin (mTOR) inhibits the process of autophagy and lysosomal degradation, acting as a potential therapeutic target for age-associated disorders. However, efficacy of targeting mTOR to treat age-related macular degeneration remains largely elusive. Here, we validated the therapeutic efficacy of the mTOR inhibitors, Torin and PP242, in clearing amyloid-β by inducing the autophagy-lysosome pathway in a mouse model with pathogenic amyloid-β with tight junction disruption of RPE, which is evident in dry age-related macular degeneration. High concentration of amyloid-β oligomers induced autophagy-lysosome pathway impairment accompanied by the accumulation of p62 and decreased lysosomal activity in RPE cells. However, Torin and PP242 treatment restored the lysosomal activity via activation of LAMP2 and facilitated the clearance of amyloid-β in vitro and in vivo. Furthermore, clearance of amyloid-β by Torin and PP242 ameliorated the tight junction disruption of RPE in vivo. Overall, our findings suggest mTOR inhibition as a new therapeutic strategy for the restoration of tight junctions in age-related macular degeneration.
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