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- 저자 : ( Mimi Chang ) (검색결과 3 건)
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( Tse-ling Fong ),( Brian Lee ),( Andy Tien ),( Mimi Chang ),( Carolina Lim ),( Ho S. Bae ) 대한간학회 2018 춘·추계 학술대회 (KASL) Vol.2018 No.1
Aims: Tenofovir alafenamide (TAF) is a novel prodrug that re -duces tenofovir plasma levels by 90% compared to tenofovir disoproxil fumarate (TDF), resulting in decreased bone mineral density (BMD) loss and renal toxicity. We aimed to study chang es in BMD and markers of renal function of chronic hepatitis B (CHB) patients previously treated with TDF who were switched to TAF. Methods: This was a prospective single-arm open-label study of 75 CHB patients treated with TDF 300 mg daily who were switched to TAF 25 mg daily and followed for 24 weeks. All patients had been treated with TDF for at least 12 months and had HBV DNA < 21 IU/mL at the time of switch. BMD and markers of renal function were taken on the day of switch and repeated after 12 and 24 weeks of TAF treatment. Results: BMD significantly increased after switch from TDF to TAF from baseline to week 12 and remained stable at week 24. Mean percent changes from baseline to week 12 in hip and spine BMDs significantly increased (+ 12.9% and +2.4%, respectively). There were significantly more patients with gains in hip (86%) or spine (76%) BMD than patients who experi enced loss (11% and 25%, respectively). No significant change in BMD was seen between week 12 and 24. There was no significant difference in eGFR<sub>CG</sub> from baseline to week 24. Sig nificant improvement was observed in urinary beta-2 micro globulin/creatinine ratio between baseline and week 12 that remained through week 24 (median change from baseline to week 12 and 24; 1.5, 1.0 and 1.1 mcg/g respectively; P<0.01). Similar changes were observed with retinol binding protein/cre atinine ratio at from baseline to week 12 and 24 (median change from baseline to week 12 and 24; 1.7, 1.3 and 1.4 mcg/g re spectively; P<0.01). There was significant increase in fractional excretion of phosphate from baseline to week 24 (11.9 to 14.0; P<0.05). Phosphate threshold for renal tubular reabsorption de creased from baseline to week 12 (2.8 to 2.6 mg/dL). Conclusions: Switching from long-term TDF to TAF among CHB patients was associated with significant improvement in BMD and some markers of proximal renal tubular function. There was no improvement in urinary phosphate handling after the switch which suggests TDF has a direct effect on bone metabo lism that is reversible. Longer term and larger studies are need ed to confirm these findings.
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External Assets as Predictors of Positive Emotions Among At-Risk Youth in Malaysia
Nor Ba'yah Abdul Kadir,Samsudin A. Rahim,Zaidah Mustapha,Mimi Hanida Abdul Mutalib,Chang Peng Kee,Rusyda Helma Mohamed 한국사회복지학회 2012 Asian Social Work and Policy Review Vol.6 No.3
The present study is among the first to examine external assets as predictors of positive emotionsamong at-risk youth. The study aims to examine the associations of external assets with positiveemotions, determine external assets as a predictor of positive emotions in phase 1, and see if thesepredictors were consistently established in phase 2. At first contact, 403 participants from lowincomeapartments in the suburbs of Kuala Lumpur, aged 13–25 years were asked to complete the25 Developmental Assets, Malaysian version. The participants were also invited to participate insocial activities organized by the PERMATA community. The same participants were approachedfour months later to examine the stability of measures. Multiple regression analysis revealed supportis the most significant predictor of positive emotions at phase 1 whilst positive peer influence,family boundaries and caring neighborhood are the significant predictors at phase 2. Results suggestedthat the presence of other external assets can enhance the positive development of at-riskyouth, however, the support must be present to some extent in the first place.
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Daud, Siti Mariam,Daud, Wan Ramli Wan,Kim, Byung Hong,Somalu, Mahendra Rao,Bakar, Mimi Hani Abu,Muchtar, Andanastuti,Jahim, Jamaliah Md,Lim, Swee Su,Chang, In Seop Elsevier 2018 ELECTROCHIMICA ACTA Vol.259 No.-
<P><B>Abstract</B></P> <P>Ceramic membranes (CMs) with different pore sizes (0.14 μm CM1, 150 kDa CM2 and 5 kDa CM3) were tested as separators in two-chamber microbial fuel cells (MFCs). The performance and ionic gradient concentration of MFCs using CMs were compared with that of cation exchange membrane (CEM), Nafion 117. MFC with CMs exhibited a higher performance than that of CEM under batch operation. The highest power density of 1790 ± 60 mW/m<SUP>2</SUP>, columbic efficiency (CE) of 41 ± 10% and internal resistance of 102 ± 13 Ω were obtained for MFC with CM3 under batch mode operation. The highest power density, columbic efficiency and internal resistance of MFC with CEM were found to be 1225 ± 20 mW/m<SUP>2</SUP>, 21 ± 1% and 400 ± 10 Ω, respectively. The highest performance of MFC with CM3 was expected due to a higher porosity of CM3 (13.8%) compared with that of CM1 (11.0%) and CM2 (11.05%). MFCs operated with catholyte containing salt solution, phosphate buffer basal medium without carbon source and yeast extract (PBBM-SA), generated lower current than with phosphate buffer (PB) as catholyte. This difference was more significant in the MFCs with the CEM Nafion 117 than with ceramic membranes. The non-selective porous ceramic membranes improved the diffusion of protons in the presence of other high concentration cations and resulted in MFC with higher performance. Hence, the porous ceramic membrane is a potential candidate separator for the development of commercial scale MFCs.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Porous ceramics were tested as separators in two-chamber microbial fuel cell (MFC). </LI> <LI> MFC with porous ceramic membrane showed a higher power density than that of PEM. </LI> <LI> The main issue with PEM is higher cation transfer compared to proton in MFC. </LI> <LI> The non-selective porous ceramic membranes improved the diffusion of proton in MFC. </LI> <LI> The PBBM supported the electrochemically active bacteria growth in anode chamber. </LI> </UL> </P>
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