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RISS 인기검색어
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- 저자 : ( Masahiro Ogura ) (검색결과 6 건)
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Ohga, Masahiro,Ogura, Mariko,Matsumura, Mastoshi,Wang, Pi-Chao The Korean Society for Biotechnology and Bioengine 2002 Biotechnology and Bioprocess Engineering Vol.7 No.5
Cell therapy applied to wound healing or tissue regeneration presents a revolutionary realm to which principles of gene engineering and delivery may be applied. One promising application is the transplantation of cells into the wounded tissue to help the tissue repair. However, when cells are transplanted from in vitro to in vivo, immune rejection occurs due to the immune response triggered by the activation of T-cell, and the transplanted cells are destroyed by the attack of activated T-cell and lose their function. Immune suppressant such as FK506 is commonly used to suppress immune rejection during transplantation. However, such kind of immune suppressants not only suppresses immune rejection in the periphery of transplanted cells but also suppresses whole immune response system against pathogenic infection. In order to solve this problem, we developed a method to protect the desired cells from immune rejection without impairing whole immune system during cell transplantation. Previously, we reported the success of constructing glomerular epithelial cells for removal of immune complex, in which complement receptor of type 1 (CR1) was over-expressed on the membrane of renal glomerular epithelial cells and could bind immune complex of DNA/anti-DNA-antibody to remove immune complex through phagocy-tosis [1]. Attempting to apply the CR1-expressing cells to cell therapy and evade immune rejection during cell transplantation, we constructed three plasmids containing genes encoding a soluble fusion protein of cytolytic T lymphocyte associated antigen-4 (CTLA4Ig) and an enhanced green fluorescent protein (EGFP). The plasmids were transfected to the above-mentioned glomerular epithelial cells to express both genes simultaneously. Using the clone cells for cell transplantation showed that mice with autoimmune disease prolonged their life significantly as compared with the control mice, and two injections of the cells at the beginning of two weeks resulted in remarkable survivability, whereas it requires half a year and 50 administrations of proteins purified from the same amount of cells to achieve the same effect.
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Structural Design of High-Rise Concrete Condominium with Wall Dampers for Vibration Control
Tsushi, Takumi,Ogura, Fumitaka,Uekusa, Masahiro,Kake, Satoshi,Tsuchihashi, Toru,Yasuda, Masaharu,Furuta, Takuya Council on Tall Building and Urban Habitat Korea 2019 International journal of high-rise buildings Vol.8 No.3
This paper presents a structural design of the "(Tentative Name) Toranomon Hills Residential Tower" which is currently under construction in Tokyo. The building is a reinforced concrete high-rise residential complex building with 54 stories above ground, 4 basement levels, and a building height of about 220 m. It is a requirement to provide the highest grade of residence in Japan, and in terms of the structural design, it is required to provide wide and comfortable spaces with high seismic performance. These requirements are satisfied by providing a total of 774 vibration control walls of two types. Also, to further improve the structural performance, steel fibers at the rate of 1.0vol% are provided in the ultra-high strength concrete used in the column members.
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( Dai Kojima ),( Hiroshi Nakai ),( Tetsuo Kobayashi ),( Kenichi Ushikoshi ),( Masahiro Ogura ),( Shoaki Ide ),( Takao Kawai ) 한국폐기물자원순환학회 2002 APLAS Vol.2002 No.2
대부분 소각잔류물이 매립된 매립지 침출수 처리시설부터 배출된 응집슬러지의 다이옥신은 열적 탈염소 과정(Hagenmaier method)에 의해서 다이옥신 농도가 380pg-TEQ/g에서 0.0031 pg- TEQ/g로 99.999%이상 분해되는 것을 bench-scale 실험을 통해서 확인되었다. 소각시설에서 배출된 배가스에 의해 다이옥신이 오염된 토양은 같은 공정으로 실험이 실시되었다. 이것 또한 6,800pg-TEQ/g에서 47pg-TEQ/g로 99% 이상 분해되는 것을 알 수 있었다. 이러한 실험을 통해 얻어진 분해상태를 기초를 하여, Hagenmaier method의 분해공정과 sodium particle 분산공정 (SP process) 의 조합은 PCBs로 오염된 토양을 제거하기 위해 full-scale 입증 실험을 실시하였다. 우선, Hagenmaier method를 통해서, PCBs 물질들은 26 mg/kg에서 0.0038 mg/kg로 다이옥신은 130pg - TEQ/g에서 0.22 pg-TEQ/g로 분해되어졌다. 열적 탈염화장치로부터 발생한 배가스 mist에 포함된 미량오염 물질은 가스 방지시설공정에 cleaning oil에 흡착되었다. 오염된 oil에 존재하는 PCBs와 다이옥신류는 SP 공정을 통해 각각 PCBs의 경우 9.8 mg/kg에서 0.056 mg/kg로, 다이옥신류의 경우 1.7 pg-TEQ/g에서 0.22 pg- TEQ/mg로 분해되었다. 이런 조합된 시스템은 오염된 토양에서의 PCBs의 경우 99.9%이상 다이옥신은 99.3%이상의 높은 분해능을 확인할 수 있었다. A bench-scale test had confirmed that dioxins in the coagulation sludge discharged from the leachate treatment plant in the landfill site where mainly incineration residue is dumped could be decomposed with the thermal dechlorination process (Hagenmaier method) from 380 to 0.0031 pg-TEQ/g, or by more than 99.999%. Soil contaminated with dioxins caused by exhaust gas from an incineration plant was tested with the same process. It was also confirmed that dioxins in the polluted soil could be decomposed from 6,800 to 47 pg-TEQ/g, or more than 99%. Based on the decomposing conditions obtained from these tests, the combined decomposition process of the Hagenmaier method and sodium particle dispersion process (SP process) was examined with a full-scale demonstration test to decontaminate soils polluted with PCBs. With the Hagenmaier method first, PCBs were decomposed from 26 mg/kg to less than 0.0038 mg/kg, and dioxins from 130 to less than 0.22 pg-TEQ/g. The trace contaminant contained in mist included in the gas exhausted from the thermal dechlorination equipment was then absorbed with gas cleaning oil in the gas cleaning unit. The PCBs and dioxins in this contaminated oil were decomposed with the sodium particle dispersion process respectively to 0.056 mg/kg and 0.22 pg-TEQ/g from 9.8 mg/kg and 1.7 pg-TEQ/g. This combined system was confirmed to have as high decomposability for decomposition of PCBs in contaminated soil as more than 99.9%, and dioxins as 99.3%.
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THE TREATMENT OF DIOXINS AND PCBS IN POLLUTED SOLIDS
( Dai Kojima ),( Hiroshi Nakai ),( Tetsuo Kobayashi ),( Kenichi Ushikoshi ),( Masahiro Ogura ),( Shoaki Ide ),( Takao Kawai ) 한국폐기물자원순환학회 2002 APLAS Vol.2002 No.1
A bench-scale test had confirmed that dioxins in the coagulation sludge discharged from the leachate treatment plant in the landfill site where mainly incineration residue is dumped could be decomposed with the thermal dechlorination process (Hagenmaier method) from 380 to 0.0031 pg-TEQ/g, or by more than 99.999%. Soil contaminated with dioxins caused by exhaust gas from an incineration plant was tested with the same process. It was also confirmed that dioxins in the polluted soil could be decomposed from 6,800 to 47 pg-TEQ/g, or more than 99%. Based on the decomposing conditions obtained from these tests, the combined decomposition process of the Hagenmaier method and sodium particle dispersion process (SP process) was examined with a full-scale demonstration test to decontaminate soils polluted with PCBs. With the Hagenmaier method first, PCBs were decomposed from 26 mg/kg to less than 0.0038 mg/kg, and dioxins from 130 to less than 0.22 pg-TEQ/g. The trace contaminant contained in mist included in the gas exhausted from the thermal dechlorination equipment was then absorbed with gas cleaning oil in the gas cleaning unit. The PCBs and dioxins in this contaminated oil were decomposed with the sodium particle dispersion process respectively to 0.056 mg/kg and 0.22 pg-TEQ/mg from 9.8 mg/kg and 1.7 pg- TEQ/g. This combined system was confirmed to have as high decomposability for decomposition of PCBs in contaminated soil as more than 99.9%, and dioxins as 99.3%.
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