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Lyoo, Kwang Soo,Hong, Sung Woo,Song, Myeong Jun,Hur, Wonhee,Choi, Jung Eun,Piao, Lian-Shu,Jang, Jeong Won,Bae, Si Hyun,Choi, Jong Young,Park, Jung Wha,Choi, Sang Wook,Yoon, Seung Kew S. Karger 2011 Intervirology Vol.54 No.6
<P>The aim of this study was to determine the prevalence of hepatitis B virus (HBV) subgenotypes, the spectrum of mutations in the precore/core region through phylogenetic analysis, and the relevance of viral characteristics in disease progression in Korean patients.</P>
류광수 ( Kwang-soo Lyoo ) 대한인수공통전염병학회 2017 창립총회 및 학술대회 초록집 Vol.2017 No.1
Coxiella burnetii is a zoonotic agent and causes coxiellosis, which is a cause of reproductive failure in a range of animal species, including abortion and stillbirth and Q fever, which is most often characterized by an acute flu-like illness, mild pneumonia, and/or hepatitis in humans. While livestock are well recognized worldwide as a source of infection, the zoonotic risk of C. burnetii infection in companion animals such as dogs may be overlooked. For serological diagnosis, indirect immunofluorescent assay (IFA) and enzyme-linked immunosorbent assay (ELISA) are generally considered good methods for prevalence surveys of coxiellosis. In this study, we conducted a nationwide survey of the seroprevalence of previous exposure to C. burnetii in dogs, dairy cattle, and Korean native cattle (a primarily beef breed) in South Korea. Serum samples obtained from 3087 Korean native cattle, 1224 dairy cattle, and 1023 dogs were collected from eight provinces in South Korea, and IFA and ELISA were performed to test for seropositivity. The prevalence of C. burnetii was 1.7% in Korean native cattle, 10.5% in dairy cattle, and 2.9% in dogs. This is the first report identifying previous exposure to C. burnetii in South Korean dogs. Furthermore, the presence of C. burnetii antibodies in companion and feral dogs indicates that dogs can be a potential reservoir species for zoonotic risk of C. burnetii infection in South Korea. Therefore, more detailed studies aiming to clarify epidemiological factors should be performed in the future.
Virulence of a novel reassortant canine H3N2 influenza virus in ferret, dog and mice models
( Woonsung Na ),( Kwang-soo Lyoo ),( Minjoo Yeom ),( Dae-gwin Jeong ),( Daesub Song ),( Chang-ung Kim ),( Jeong-ki Kim ),( Daesub Song ) 대한인수공통전염병학회 2016 창립총회 및 학술대회 초록집 Vol.2016 No.1
The outbreak of a canine influenza virus (CIV) H3N2 reassortanted from pandemic (pdm) H1N1 and CIV H3N2 in companion animals has underscored the urgent need to monitor CIV infection for potential zoonotic transmission of influenza viruses to humans. In this study, we assessed the virulence of a novel CIV H3N2 (VC378) from a pdm H1N1 and CIV H3N2 coinfected dog in ferrets, dogs, and mice. Significantly enhanced virulence of VC378 was demonstrated in mice, although the transmissibility and pathogenicity of VC378 were similar to those of classic H3N2 in ferrets and dogs. This is notable because mice inoculated with an equivalent dose of classic CIV H3N2 showed no clinical signs and no lethality. We found that the PA and NS gene segments of VC378 were introduced from pdmH1N1, and these genes included amino acid substitutions; PAP224S and NS-I123V, that were previously found to be associated with virulence enhancement in mice. Thus, we speculate that the natural reassortment of CIV between pdm H1N1 and CIV H3N2 can confer virulence and that continuous surveillance is needed to monitor the evolution of CIV in companion animals.
( Jeong Ki Kim ),( Jeong Hyun Nam ),( Kwang Soo Lyoo ),( Hyoungjoon Moon ),( Woonsung Na ),( Eun Jung Song ),( Minjoo Yeom ),( Sang Mu Shim ),( Dae Gwin Jeong ),( Dong Jun An ),( Bo Kyu Kang ),( Daesu 한국미생물 · 생명공학회 2016 Journal of microbiology and biotechnology Vol.26 No.6
H3N2 canine influenza virus emerged in South Korea in 2007 and subsequently spread to China and Thailand, causing epidemic or endemic respiratory diseases in dogs. Through intermammalian species transmission, the virus has also infected cats. However, no direct evidence of significant genetic evolution has been reported since its first emergence. Here, we describe in depth the genetic and molecular characteristics of the ancestral strain (i.e., the first virus isolate from South Korea) of the H3N2 canine influenza virus currently circulating in East Asia.
( Sung Woo Kim ),( Won Hee Hur ),( Kwang Soo Lyoo ),( Jung Eun Choi ),( Sung Woo Hong ),( Young Kee Lee ),( Seung Kew Yoon ) 대한간학회 2012 춘·추계 학술대회 (KASL) Vol.2012 No.1
Background: NAFLD (nonalcoholic fatty liver disease) has a wide spectrum of liver pathogenesis from simple hepatic steatosis to cirrhosis. NASH (Nonalcoholic Steatohepatitis) is characterized by hepatocyte injury and inflammatory cell infiltration, which is linked with peripheral insulin resistance and increased triglyceride in the liver. Pharmacological properties of oleuropein are anti-oxidant, anti-inflammatory, and anti-ageing. The purposes of this study was to establish an NASH mouse model fed with HFD and to demonstrate the pharmacological effect of oleuropein using the appropriative animal model. Methods: C57BL/6 mice were divided into 3 groups; a normal diet group (ND), a 60% high fat diet group (HFD), 0.05% oleuropein-supplemented high fat diet group (HWO). HWO were fed 0.05% oleuropein-supplemented high fat diet after 6 months. The effect of oleuropein on these models was studied using biochemical, histological and molecular markers. Expression of mRNA level (related adipogenesis, inflammation, and fibrosis) was analyzed by real-time PCR between HFD and HWO. Results: The body weight, total cholesterol, TG, FFA, AST, and ALT values of HFD for 6, 9, and 12 months were higher than that of ND. The NAFLD activity score (NAS) of HFD were increased to inflammation stage at 6 month, compared to ND. HWO was significantly increased to NAS and fibrosis grade, but steatosis grade was not changed. The mRNA levels of LXR, TNF-α and collagen was decreased with treatment period in HWO, but ap2 and α-SMA was not changed. Conclusions: We produced a high fat diet induced NASH model that displayed histopathological features of NAFLD to NASH. The therapeutic effect of oleuropein was prevented with progression of NAFLD to NASH. Therefore, it is speculated that oleuropein may be pharmacologically useful to prevent the progression of steatohepatitis and fibrosis and could be a promising agent of medicine for human NASH. This study was supported by a grant of the Korean Health Technology R&D Project, Ministry of Health & Welfare, Republic of Korea. (A090282).
Kim, Kiju,Choi, Jong-Young,Lyoo, Kwang-Soo,Hahn, Tae-Wook The Korean Society of Veterinary Science 2018 大韓獸醫學會誌 Vol.58 No.3
The capsid protein of porcine circovirus type 2 (PCV2) encoded by open reading frame 2 (ORF2) is important for neutralizing activity against PCV2 infection. This study investigated the heterogeneity of the ORF2 gene of PCV2 isolated in Korea during 2016-2017. The results revealed that PCV2d is currently the predominant genotype. Moreover, comparison of ORF2 from 17 PCV2 isolates revealed 88.3-100% homology at the nucleotide (deduced amino acid 86.3-100%) level. Interestingly, 61.5% (8/13) of the PCV2d isolates had glycine at position 210. These data provide a useful information for PCV2 epidemiology in Korea.