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Kwan Joong Joo,Kwangchon Ko 대한비뇨기종양학회 2011 대한비뇨기종양학회지 Vol.9 No.2
Purpose: We constructed oncolytic virus from herpes simplex virus (HSV), which selectively targets the activated Ras signaling pathway in cancer cells. We evaluated the anticancer effects of the oncolytic HSV against human bladder cancer cell lines. Materials and Methods: Oncolytic HSV type 2 (FusOn-H2) was constructed by replacing protein kinase domain of the ICP10 with green fluorescent protein gene. We seeded T24, 5637, TCC-SUP, and RT4 cell lines into 24 well plates respectively and infected them with FusOn-H2 at 0.1 and 0.01 plaque forming unit (pfu)/cell, or left them uninfected. Fluorescence microscopic examination was performed to characterize phenotypical finding after incubation for two days. Cells were harvested 24, 48 or 72 hours later and the number of viable cells determined after Trypan blue staining. The percentage of viable cells was calculated by dividing the number of cells excluding Trypan blue in the infected well by the number excluding the stain in the uninfected well. Results: In FusOn-H2 infection, syncytia formation of dead cells was present and green fluorescence expression was observed. In all cell lines, infection with FusOn-H2 killed the tumor cells more and more as the time goes by. By 72 hours, FusOn-H2 almost completely eradicated the tumor cells exposed to virus doses of 0.1pfu/cell. There was no difference in cell destruction by oncolytic HSV between coxsackie-adenovirus receptor (CAR) expression cell lines (5637 and RT4) and CAR deficiency cell lines (T24 and TCC-SUP). Conclusions: Oncolytic HSV has potent anticancer activity against bladder cancer irrespective of CAR expression. Probably, the treatment using oncolytic HSV in bladder cancer patients would lead to therapeutic benefits.
주관중 한국북방학회 1997 韓國北方學會論集 Vol.3 No.-
What is meant by "Northern areas" in this paper is refered to the ample space which spread out in Korean hand-fun shape of rhombic form up to the north of Korean peninsula. This area comprises variety of nations such as China, Russia(CIS), Mongol, Republic of Kazakhstan, Uzbekistan and so forth. Large number of Korean compatriots have been living in these nations. Here I am not argueing about their numbers of populations but what I matter in this paper is the character of our fellow countrymenship. I made a scrutiny into whether or not they are still Koreans in its real sense. The fellow countrymenship tends to be enriched its contents through the emotional and sentimental chanells rather than a scientific, rational or theoretical ways. Hitherto, we have been saying customarily the fellow countrymenship as being inherited bloodlineage(pedigree) undergrading the mental and cultural successions. Afterall, we carne to know through the cultivation of genetics and hereditary engineering that the accession of a race do not be inheritted by the blood of parents but the gene of parents. The gene has nothing directly to do with the blood but it is the work of sperm and egg cell. The blood types are all diverse even in a family circle. The future of the duplicated-human, currently in a vogue is becoming a threat to the formation of a kinship of a race. This paper examines the root of Korean founders in search of their lands of foundations. These are good reasons to affirm that the lands of Korean founders are located mainly in todays China. The answers to the inquirely to the essence of the foundations of Korean ancestry are happened to be identical in time, place and persons among the antique documents of China and Korea. The earliest founder of Korean race Hanin initiated our history in Tianchi(Heavenly lake) of Tiansan of China nine thousand years ago. The antique Chinese documents are telling us that even the three founding fathers of China, namely, Bokki, Shinnong and Whangje(the yellow emperor) are the offsprings of Tongyee Race which refers to Korean race. Furthermore the eminent Chinese emperor YO and SHUN also fall into the category of Dongyee persons. As for the nationality, Chinese historians are strongly addicted to the "territorial principle" whereas Korean historians, antique or current, rather take the "personal principle." Particularly noteworthy is that Korean race has long been a horse-riding Calvary race and constantly moving and flowing toward the east repeating the union and division, i.e, amalgamation and segregation. Number of Chinese antique documents suggest us that Chinese antique empires such as Hsia, Yin and Chou were no other than the antique Korean race. The Chinese people have a very popular legend, the story about the encounter of the emperor Mok of Chou and "the egress mother of the west" in Yoji garden which location is identified as to be the Tiarchi(Heavenly lake) of Tiansan. Tianchi as I observed before, is no other than the land of foundation of Korean race nine thousands of years ago. Several great folding screen paintings of Yoji which seem to be the work of two or three hundred years ago should be evaluated to the effect that they are the artistic works depicting the legend of Korean folk tale, not Chinese. The origin of Chinese history shall be traced back to the days of the emperor Whangje who fought long war against Chiwoo the fourteenth Hanwoong almost three thousands of years before Christ. The descendants of Chiwoo became the Old Chosun horse-riding race moving gradually up to Manchuria, the northen area and on the other hand, offsprings of Whangje fumed out to be the Chinese horse-riding race having a predominant rule over the Yellow river. This was the first division of Dongyee race and the Whangje has been adored by the Chinese people as being the founder and the first emperor of China. The ethnicity(race) and State(nation) are not same in their conceptions. The former is natural entity whereas the latter is assumed to be artificial one. Moreover, the former is built on the "personal principle" whereas the latter is definitely stands on the "territorial principle". The three requirements of a State are the people, the sovereignty and the territory. Eventhough a man may be a descentant of Korean forefather by blood or gene, long years of habitation and inhabitation in folk customs of the alien State, he can hardly be identified as a Korean. Here, the "personal principle" of the ethnicity subjects to a bit of modification. That is to say, as the prerequisite for a compatriot, the folk customs and cultural life feature of the inhabiting territory must be taken into consideration. A personality consists of the body and the spirit. A person owing to the long inhabitation in an alien territory, undergoes the division between the body(blood or gene) and the spirit(folk custom or cultural). Who is the real Chinese? Who might be the real Korean? What is true character of a Japanese? What is the real identification of a Korean? This matter of the true character and real identification of the nationality and the ethnicity entail the verification of the orthodoxy question. Orthodoxy, teeing different from the legitimacy is comprehended as to mean the right systematic pedigree which righty inherit the idea or philosophy of the founder. The true Korean or true compatriot at least, ought to satisfy the three requirements. The first is the body condition(by blood or gene). The second requirement is orthodox recognition and thirdly condition is the well maintenance of the cultural traditions and folk customs. The whole endeavor and pretence for being a Korean are likely to abort without the sufficiency of the foregoing three requirements. In this paper I added the languages and religions of the northern races and States for a reference.