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Yoo, Junsang,Lee, Euiyeon,Kim, Hee Young,Youn, Dong-ho,Jung, Junghyun,Kim, Hongwon,Chang, Yujung,Lee, Wonwoong,Shin, Jaein,Baek, Soonbong,Jang, Wonhee,Jun, Won,Kim, Soochan,Hong, Jongki,Park, Hi-Joon Nature Publishing Group, a division of Macmillan P 2017 Nature nanotechnology Vol.12 No.10
Electromagnetic fields (EMF) are physical energy fields generated by electrically charged objects, and specific ranges of EMF can influence numerous biological processes, which include the control of cell fate and plasticity. In this study, we show that electromagnetized gold nanoparticles (AuNPs) in the presence of specific EMF conditions facilitate an efficient direct lineage reprogramming to induced dopamine neurons in vitro and in vivo. Remarkably, electromagnetic stimulation leads to a specific activation of the histone acetyltransferase Brd2, which results in histone H3K27 acetylation and a robust activation of neuron-specific genes. In vivo dopaminergic neuron reprogramming by EMF stimulation of AuNPs efficiently and non-invasively alleviated symptoms in mouse Parkinson's disease models. This study provides a proof of principle for EMF-based in vivo lineage conversion as a potentially viable and safe therapeutic strategy for the treatment of neurodegenerative disorders.
ISG를 적용한 1.0 L 가솔린엔진의 성능개선에 관한 연구
유준상(Junsang Yoo),윤여빈(Yubin Yoon),조용석(Yongseok Cho),최웅철(Woongchul Choi),이호기(Hoki Yi),송춘섭(Chunsub Song) 한국자동차공학회 2013 한국자동차공학회 부문종합 학술대회 Vol.2013 No.5
This paper presents an advanced ISG system for internal combustion engines and hybrid electric vehicle applications to reduce fuel consumption, reduce emissions, and enhance energy efficiency and increase torque. The ISG system provides all the functions of engine starter motor and alternator in one electric system installed between the engine without significantly increasing the weight and volume of the vehicle. Torque improvement test were performed at low engine speed with ISG system that deliver WRSM power to the crankshaft. Conclusions are drawn as to the torque improvement of the ISG system.
Conversion of Methylglyoxal to Acetol by Escherichia coli Aldo-Keto Reductases
Ko, Junsang,Kim, Insook,Yoo, Seokho,Min, Bumchan,Kim, Kyungmin,Park, Chankyu American Society for Microbiology 2005 Journal of Bacteriology Vol.187 No.16
<B>ABSTRACT</B><P>Methylglyoxal (MG) is a toxic metabolite known to accumulate in various cell types. We detected in vivo conversion of MG to acetol in MG-accumulating <I>Escherichia coli</I> cells by use of <SUP>1</SUP>H nuclear magnetic resonance (<SUP>1</SUP>H-NMR) spectroscopy. A search for homologs of the mammalian aldo-keto reductases (AKRs), which are known to exhibit activity to MG, revealed nine open reading frames from the <I>E. coli</I> genome. Based on both sequence similarities and preliminary characterization with <SUP>1</SUP>H-NMR for crude extracts of the corresponding mutant strains, we chose five genes, <I>yafB</I>, <I>yqhE</I>, <I>yeaE</I>, <I>yghZ</I>, and <I>yajO</I>, for further study. Quantitative assessment of the metabolites produced in vitro from the crude extracts of these mutants and biochemical study with purified AKRs indicated that the <I>yafB</I>, <I>yqhE</I>, <I>yeaE</I>, and <I>yghZ</I> genes are involved in the conversion of MG to acetol in the presence of NADPH. When we assessed their in vivo catalytic activities by creating double mutants, all of these genes except for <I>yqhE</I> exhibited further sensitivities to MG in a glyoxalase-deficient strain. The results imply that the glutathione-independent detoxification of MG can occur through multiple pathways, consisting of <I>yafB</I>, <I>yqhE</I>, <I>yeaE</I>, and <I>yghZ</I> genes, leading to the generation of acetol.</P>
Salusin-β mediate neuroprotective effects for Parkinson's disease
Chang, Yujung,Yoo, Junsang,Kim, Hongwon,Park, Hi-Joon,Jeon, Songhee,Kim, Jongpil Elsevier 2018 Biochemical and biophysical research communication Vol.503 No.3
<P><B>Abstract</B></P> <P>Neuropeptides, small peptides found in many mammalian brain, play key roles in communicating with each other to modulate neuronal activity. Here, we reported that endogenous neuropeptide salusin-β has neuroprotective effects on the midbrain dopamine neurons and can be used as an effective therapeutic treatment for Parkinson's disease (PD). We found that the MrgprA1 receptor mediates the neuroprotective effects of salusin-β on the midbrain dopamine neurons. Importantly, intranasal administration of salusin-β in a PD mouse model show the neuroprotection of dopaminergic neurons and increased the survival of midbrain dopamine neurons. Furthermore, inhibition of the salusin-β receptor, MrgprA1, abolished the neuroprotective effects induced by salusin-β. Taken together, these results demonstrate the novel role of salusin-β in the central nervous system and salusin-β can be used as a novel therapeutic to effectively treat PD.</P>