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Phospholipase-catalyzed hydrolysis in an artificial cell membrane in the presence of melittin.
Lee, Jinyoung,Lee, Joo-Kyung,Busnaina, Ahmed,Park, BaeHo,Lee, HeaYeon American Scientific Publishers 2013 Journal of Nanoscience and Nanotechnology Vol.13 No.1
<P>Biomimicry involves the use of the structure and function of biological systems as models for the design and engineering of materials and machines. An artificial cell membrane was developed using biomembrane components, and the membrane, formed by a lipid bilayer, was analyzed using surface plasmon resonance (SPR) to monitor hydrolysis by phospholipase (PL). The simultaneous atomic force microscope (AFM) images show that PL catalyzed the nanometer-scale hydrolysis of the artificial lipid biomembranes through enzymatic hydrolysis. In addition, it was confirmed that the combination of PL and melittin allowed the control of enzyme hydrolysis for the degradation of the lipid bilayer. Regarding the expected activating effect of melittin on hydrolysis, no difference with respect to the non-treated lipid membrane was observed in the AFM images. It is assumed that the partitioning of melittin into the membrane might prevent the binding or hydrolysis of Phospholipase A2 (PLA2). This study provides basic knowledge on a new approach for patterning biomimicking lipid membranes on a nano-scale.</P>
Detection of single nucleotide polymorphisms using a biosensor-containing titanium-well array.
Lee, Joo-Kyung,Cho, Si-Hyeong,Lee, Jinyoung,Lee, Jung-Hwan,Kim, Ah Young,Park, Bae Ho,Park, Jin-Goo,Busnaina, Ahmed,Lee, Hea Yeon American Scientific Publishers 2013 Journal of Nanoscience and Nanotechnology Vol.13 No.1
<P>The rapid identification and verification of single nucleotide polymorphisms (SNPs) were demonstrated using a well array sensor containing anti-biofouling titanium (Ti). Probe single-stranded DNA (ssDNA) was immobilized inside a titanium-well array on amine-modified glass surfaces with anti-biofouling behavior via a streptavidin-biotin interaction. Fluorescence intensity changes originating from the hybridization of nucleic acids to protein-bound nucleic acids linked to Alexa Fluor (FL) 647 were observed. The protocol was highly sensitive and reproducible for the detection of DNA hybridization. Significant changes in fluorescence signals were observed when using target DNA with a single base mismatch, indicating that this method is applicable to SNP detection. The microarray technology for the detection of SNPs using anti-biofouling Ti and other methods can be used as a highly sensitive in vitro medical sensor, as highlighted by an increase in genotyping accuracy.</P>
Tubercles patterns of the genus Linaeidea (Coleoptera: Chrysomelidae) from Korea
Jinyoung Park,HeeWook Cho,Jong Eun Lee 한국응용곤충학회 2008 한국응용곤충학회 학술대회논문집 Vol.2008 No.10
The genus Linaeidea Motschulsky, 1860, contains six species, and is distributed in China, Japan, USSR, Europe, with only two species known in Korea (Gressitt and Kimoto, 1963; Seeno and Wilcox, 1982; Kimoto and Takizawa, 1994; Lee and An, 2001). Morphological notes of the immature stages and life history of Japanese L. aenea (Linne, 1758) were well studied by Kimoto (1962)and Kimoto and Takizawa (1994). Very little is known about the immature stages of this genus from Korea: only the larva of L. aenea have been briefly described and illustrated by Lee (1996). According to Hennig (1938), this genus is separable from the genus Chrysomela, in having sternal tubercles which are disappeared in the last instar larvae. However, the L. adamsi was not applied in the diagnosis character of this genus. The purpose of this results are to provide a key, detailed description, illustration and tubercles patterns of all known Korean species of genus Linaeidea as the basic data for the phylogenetic study the subfamily Chrysomelinae.
( Jinyoung Moon ),( Jeong Seok Lee ),( Young Im Yoon ),( Sung Hae Chang ),( Yeon Ah Lee ),( You-jung Ha ),( Eun Ha Kang ),( Yong-beom Park ),( Hwa Jung Lee ),( Jung-yoon Choi ),( Eun Young Lee ) 대한류마티스학회 2021 대한류마티스학회지 Vol.28 No.4
Objective. The increase in mortality in rheumatoid arthritis (RA) patients with interstitial lung disease (ILD) is well known. However, there are few studies on serum markers that can evaluate acute exacerbation or prognosis in RA-ILD patients. The purpose of this study was to identify the association between biomarkers and lung lesions in patients with RA-ILD. Methods. We analyzed 153 patients with serum samples in a prospective, multicenter cohort of Korean RA-ILD patients. The serum levels of biomarkers, matrix metalloproteinase (MMP-7), surfactant protein-D (SP-D), and Krebs von den Lungen-6 (KL-6) were measured and correlated with forced vital capacity (FVC), diffusing capacity for carbon monoxide (DLCO) and the results of computed tomography (CT). CT results were interpreted semi-quantitatively according to the extent of lung lesions (grade 1, 0%∼25%; grade 2, 26%∼50%; grade 3, 51%∼75%; grade 4, 76%∼100%). Results. MMP-7, SP-D, and KL-6 were negatively correlated with FVC (MMP-7, r=-0.267, p=0.001; SP-D, r=-0.250, p=0.002; KL-6, r=-0.223, p=0.006) and DLCO (MMP-7, r=-0.404, p<0.001; SP-D, r=-0.286, p=0.001; KL-6, r=-0.226, p=0.007). In addition, MMP-7, SP-D, and KL-6 tended to increase with higher grades of lung lesions on CT (MMP-7, p=0.013; SP-D, p<0.001; KL-6, p<0.001). Conclusion. MMP-7, SP-D, and KL-6 can be used to evaluate the functional and anatomical status of lung involvement in the RA-ILD patients. (J Rheum Dis 2021;28:234-241)
Acceleration of poly(L-lactide) degradation by TiO2 nanoparticles in sunlight.
Lee, Jinyoung,Lee, Ju-Kyoung,Park, Bae Ho,Busnaina, Ahmed,Lee, Hea Yeon American Scientific Publishers 2013 Journal of Nanoscience and Nanotechnology Vol.13 No.10
<P>Poly(L-lactide) (PLA) is known to eventually be degraded into water and carbon dioxide by the microorganisms of the natural world. Titanium dioxide (TiO2) has been used in the biomedical and bioengineering fields as a photocatalyst. The purpose of this research project is to evaluate the influence of TiO2 added to PLA films both before and after irradiation of the films with sunlight. The PLA-TiO2 films were prepared by the addition of TiO2 (size: > 100 nm) nanoparticles to PLA. The surface changes of the PLA film were investigated before and after the films were exposed to sunlight. Tiny holes were observed in the PLA film without TiO2 nanoparticles after irradiation with sunlight, whereas large pits formed in the PLA-TiO2 films. It is suggested that PLA was degraded by the ultraviolet rays in sunlight. In addition, the decomposition speed was thought to be enhanced by the addition of TiO2, which acted as a catalyst.</P>
Kang, Jinyoung,Yang, Jaemoon,Lee, Jaewon,Oh, Seung Jae,Moon, Seyoung,Lee, Hong Jae,Lee, Sang Cheon,Son, Joo-Hiuk,Kim, Donghyun,Lee, Kwangyeol,Suh, Jin-Suck,Huh, Yong-Min,Haam, Seungjoo Royal Society of Chemistry 2009 Journal of materials chemistry Vol.19 No.19
<P>We fabricated <I>de novo</I> biocompatible mineral plasmon resonants for localized and systemic treatment of cancer. Biodegradable calcium-phosphate gold nanocomposites were synthesized for inducing a superior surface plasmon resonance effect. The combination of therapeutic antibody, Erbitux<SUP>®</SUP> and NIR laser with nanocomposites demonstrated the potential for selective bimodal cancer treatment by combination of EGFR-induced signaling inhibition as a systemic treatment and localized photothermal effects caused by the NIR laser.</P> <P>Graphic Abstract</P><P>De novo smart calcium-phosphate gold nanocomposites as superior surface plasmon resonants are developed for localized photothermal and systemic treatment of epithelial cancer. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=b822835c'> </P>
섬망 환자의 치료에서 Haloperidol과 Quetiapine의 효과 비교 : 전향성 개방 연구
이진영(Jinyoung Lee),김상헌(Sang Heon Kim),서유진(Eugene Seo),이준영(Joon Young Lee),심제용(Jaeyong Shim),이양현(Yanghyun Lee) 대한생물치료정신의학회 2006 생물치료정신의학 Vol.12 No.2
본 연구는 섬망 환자를 대상으로 haloperidol 또는 quetiapine으로 치료하였을 때의 치료 효과와 부작용을 비교 평가하였는데, haloperidol군과 quetiapine군 모두에서 치료 후에 섬망 증상의 현저한 호전을 보였고, 환자가 섬망 증상에서 호전되는 데 걸린 기간에서도 차이를 보이지 않았다. 또한 사용한 두 약물을 등가용량으로 비교하였을 경우 quetiapine이 haloperidol 보다 적은 용량으로 섬망의 치료에 효과적이라는 것을 보였다. 대부분의 환자가 심각한 부작용이 없이 섬망에서 호전되었으나, haloperidol을 사용하였던 1명의 환자에서 추체외로계 부작용으로 인해 약물을 중단하였고, quetiapine을 사용하였던 환자에서는 추체외로계 부작용을 호소하는 환자가 없었다. Quetiapine을 사용하였던 2명의 환자에서 진정작용을 호소하였으나 경한 정도였고 약물을 중단하지는 않았다. Quetiapine은 섬망의 치료에서 haloperidol과 동등한 효과를 보이며, 특히 추체외로계 부작용이 적기 때문에 노인 환자의 섬망 치료에서 보다 안전하게 사용할 수 있으리라는 가능성을 보였다. 본 연구는 섬망이 발생한 환자들을 전향성으로 평가하였다는 데 의의가 있겠지만, 향후에 더 많은 수의 환자를 대상으로 한 이중맹검 위약대조군 연구가 필요할 것이다. Objectives:Delirium is a complex psychiatric syndrome with an acute onset and a fluctuating course. Typical antipsychotics, especially haloperidol, have been used as the main tool for pharmacological treatment of delirium. Recently, the newly developed atypical antipsychotics have been used successfully in control of delirium. The purpose of this prospective, open-clinical trial is to compare the clinical efficacy and tolerability of haloperidol and quetiapine for the treatment of delirium. Methods:Between July 2005 and June 2006, 36 patients who were diagnosed as having delirium according to the criteria of the DSM-IV were enrolled in this study from psychiatric practice settings and from consultation department. They were randomly assigned to be treated with a flexible-dose regimen of haloperidol(n=19) or quetiapine (n=17). K-DRS, K-DRS-R-98, CGI, MMSE-K, and ESRS had been assessed repeatedly until the K-DRS score reached 12 or less. We assumed that the patient whose K-DRS score had reached 12 or less was recovered from delirium. Results:Sixteen subjects in haloperidol group and sixteen subjects in quetiapine group completed the study. The mean dosage of antipsychotics for delirium is 2.9mg(SD=1.8) of haloperidol and 39.8mg(SD=28.9) of quetiapine. K-DRS and K-DRS-R-98 scores in both groups were significantly decreased after individual treatments. But there were no significant differences of changing extent of CGI-Improvement, MMSE-K, K-DRS and K-DRSR- 98 scores between the groups. There was no significant difference in duration of treatment and clinical improvement between the groups. Most of the patients were well tolerated to the adverse events of each antipsychotic drug but only one patient who had been treated with haloperidol showed extrapyramidal symptom after the medication. Conclusion:Quetiapine may be more useful than haloperidol in old aged patients with delirium because of its safety and low dose effectiveness. This trial is a prospective, open-label, flexible dose study with a small sample size, so further double-blind placebo-controlled studies with a large sample size will be necessary.
First Record of Genus Olibrus (Coleoptera: Phalacridae) from Korea
Mi Jin Lee,Jinyoung Park,Jong Eun Lee 한국응용곤충학회 2013 한국응용곤충학회 학술대회논문집 Vol.2013 No.04
Olibrus Erichson, 1845 and Olibrus particeps Mulsant & Rey, 1861 (Coleoptera: Cucujoidea: Phalacridae) are reported from Korea for the first time and historical review of the taxonomic position of this genus is provided. The genus Olibrus Erichson is one of the common phalacrid beetles being widely distributed throughout the world. This genus is easily distinguished from other phalacrid genera by combination of the following characters: Antennae inserted at sides of front, base visible from above; Last segment of antenna softly indented; Basal metatarsomere shorter than second; Elytral surface very polished. O. particeps was found in Andong-si and Yeongju-si, Gyeongsangbuk-do of Korea, bringing the number of species within the Korean Phalacridae to 2 species. In this study, we provide a redescription of O. particeps Mulsant & Rey, and illustrations of its genitals and other appendages.