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[PB-0062] Isolation of soybean ARGONAUTE protein involved in seed coat color pigmentation
Jinwon Lee(Jinwon Lee),Gyu Tae Park(Gyu Tae Park),Hyun Jo(Hyun Jo),Jeongyun Ko(Jeongyun Ko),Junbeom Park(Junbeom Park),Jeong-Dong Lee(Jeong-Dong Lee),Jong Tae Song(Jong Tae Song) 한국육종학회 2022 한국육종학회 공동학술발표집 Vol.2022 No.-
[PB-0064] Isolation of Ab-rg rich saponin mutants from EMS-induced population in soybean
Junbeom Park(Junbeom Park),Jagadeesh Sundaramoorthy(Jagadeesh Sundaramoorthy ),Jinwon Lee(Jinwon Lee),Jeong-Dong Lee(Jeong-Dong Lee),Hak Soo Seo(Hak Soo Seo),Jong Tae Song(Jong Tae Song) 한국육종학회 2022 한국육종학회 공동학술발표집 Vol.2022 No.-
Park, Ha Young,Kwon, Mi Jung,Kang, Ho Suk,Kim, Yun Joong,Kim, Nan Young,Kim, Min Jeong,Min, Kyueng-Whan,Choi, Kyung Chan,Nam, Eun Sook,Cho, Seong Jin,Park, Hye-Rim,Min, Soo Kee,Seo, Jinwon,Choe, Ji-Yo Elsevier 2019 Human pathology Vol.87 No.-
<P><B>Summary</B></P> <P>Rectal neuroendocrine tumors (NETs) are the most common gastrointestinal (GI) NETs with an uncertain malignant potential despite their small size. There are limited data about driver mutations in rectal NETs, which may explain the tumors' unexpected behavior or common histologic morphology with other GI-NETs. Here, we investigated the clinically and pathologically relevant mutations of rectal and nonrectal NETs and compared the frequency and clinical significance of detected mutations between them. We sequenced 84 primary GI-NETs (69 rectal, 7 gastric, 5 appendiceal, and 3 sigmoid colon NETs) and 3 metastatic GI-NETs using targeted next-generation sequencing. Twenty-one rectal NETs (30.4%) showed at least 1 mutation in 24 cancer-related genes; the most common mutations were <I>TP53</I> (10.1%) and <I>FBXW7</I> (7.2%), of which 73% were pathogenic/likely pathogenic mutations. <I>TP53</I> (p.R337C and p.R213*), <I>PTEN</I> (p.W111*, p.Q214*), <I>CDKN2A</I> (p.W110*), <I>FBXW7</I> (p.R465H), and <I>AKT1</I> (p.R23Q) were repetitive mutations found exclusively in rectal NETs, whereas <I>SMAD4</I> (p.R361C) and <I>STK11</I> (p.D176N) were repetitive mutations found only in gastric NETs. <I>PTEN</I> (p.G129K), <I>EGFR</I> (p.E709K), and <I>KIT</I> (p.V555I) were shared mutations between rectal and appendiceal NETs, whereas <I>SMAD4</I> (p.R361C), <I>ALK</I> (p.G1202R), <I>VHL</I> (p.Q132*), and <I>IDH1</I> (p.R132H) were concurrently detected between rectal and gastric NETs. GI-NETs with higher histologic grades, lymphovascular invasion, or recurrence tended to have higher numbers of mutation variants than other tumors; however, there was no significant difference. In conclusion, rectal NETs commonly carried pathogenic/likely pathogenic mutations. Because most mutations were identified in nonhotspot positions, next-generation sequencing is useful in identifying potential drug targets in rectal NETs.</P> <P><B>Highlights</B></P> <P> <UL> <LI> <I>TP53</I>, <I>PTEN</I>, and <I>SMAD4</I> are commonly mutated in gastrointestinal NETs. </LI> <LI> Seventy-five percent of mutations in rectal NETs are pathogenic/likely pathogenic mutations. </LI> <LI> Eighty-seven percent of genes are mutated in nonhotspot positions. </LI> </UL> </P>
Dominance of climate warming effects on recent drying trends over wet monsoon regions
Park, Chang-Eui,Jeong, Su-Jong,Ho, Chang-Hoi,Park, Hoonyoung,Piao, Shilong,Kim, Jinwon,Feng, Song Copernicus GmbH 2017 Atmospheric chemistry and physics Vol.17 No.17
<P>Abstract. Understanding changes in background dryness over land is key information for adapting to climate change because of its critical socioeconomic consequences. However, causes of continental dryness changes remain uncertain because various climate parameters control dryness. Here, we verify dominant climate variables determining dryness trends over continental eastern Asia, which is characterized by diverse hydroclimate regimes ranging from arid to humid, by quantifying the relative effects of changes in precipitation, solar radiation, wind speed, surface air temperature, and relative humidity on trends in the aridity index based on observed data from 189 weather stations for the period of 1961-2010. Before the early 1980s (1961-1983), change in precipitation is a primary condition for determining aridity trends. In the later period (1984-2010), the dominant climate parameter for aridity trends varies according to the hydroclimate regime. Drying trends in arid regions are mostly explained by reduced precipitation. In contrast, the increase in potential evapotranspiration due to increased atmospheric water-holding capacity, a secondary impact of warming, works to increase aridity over the humid monsoon region despite an enhanced water supply and relatively less warming. Our results show significant drying effects of warming over the humid monsoon region in recent decades; this also supports the drying trends over warm and water-sufficient regions in future climate. </P>
Performance Feedback and Risk Taking
Park Jinwon,Lee Kyungmook 한국경영학회 2018 한국경영학회 통합학술발표논문집 Vol.2018 No.8
We contribute to the performance feedback model by developing a theoretical framework that predicts the moderating effects of evaluation deadline proximity, remaining contract duration of CEO, and audience pressure between performance feedback and risk taking behaviors. We contend that in a negative attainment discrepancy context, deadline-proximity adjusted performance-aspiration gaps will increase the risk taking propensity of CEOs and remaining contract duration of CEOs and audience pressure will intensify the effects of deadline-proximity adjusted performance-aspiration gaps on risk taking behaviors. The analysis of the Major League Baseball games from 2007 to 2016 yields the following results. First of all, deadline-proximity adjusted performance-aspiration gaps showed predicted positive effects on risk taking behaviors. Second, the remaining contract duration of CEOs intensified the positive effect of the deadline-proximity adjusted performance-social aspiration gap on risk taking behaviors. Contrary to our predictions, however, the positive effect of the deadline-proximity adjusted performance-historical aspiration gap on risk taking behaviors decreased by audience pressure.
High MET copy number and MET overexpression: poor outcome in non-small cell lung cancer patients.
Park, Sanghui,Choi, Yoon-La,Sung, Chang Ok,An, Jungsuk,Seo, Jinwon,Ahn, Myung-Ju,Ahn, Jin Seok,Park, Keunchil,Shin, Young Kee,Erkin, Ozgur Cem,Song, Kyung,Kim, Jhingook,Shim, Young Mog,Han, Joungho Gutenberg 2012 Histology and histopathology Vol.27 No.2
<P>The aim of this study was to evaluate the prevalence and prognostic role of increased gene copy number and protein expression of MET and EGFR in non-small cell lung cancer (NSCLC) patients. Samples were collected from 380 patients with surgically resected NSCLC, and fluorescence in situ hybridisation (FISH) and immunohistochemistry (IHC) were performed. EGFR amplification and high polysomy (EGFR FISH-positive) were observed in 9.7% and 17.4% of the patients, respectively. EGFR was overexpressed (EGFR IHC-positive) in 19.2% of the patients. Neither EGFR FISH-positive nor EGFR IHC-positive status affected survival after resection. Increased MET copy number (MET FISH-positive by University of Colorado Cancer Center criteria) was observed in 11.1% of the patients (high polysomy, 8.7%; gene amplification, 2.4%). According to the Cappuzzo system, 7.1% of the patients were MET FISH-positive. MET FISH positivity was a negative prognostic factor, especially in patients with adenocarcinoma histology (p=0.040), female gender (p=0.010), old age (p=0.084), and EGFR FISH negativity (p=0.020) at the univariate level but not at the multivariate level. MET was overexpressed (MET IHC-positive) in 13.7% of the patients and associated with shorter overall and disease-free survival (p=0.010 and p=0.056, respectively). Multivariate analysis revealed that MET IHC-positive patients had a significantly increased risk of death (hazard ratio, 1.618; 95% confidence interval, 1.066-2.456; p=0.024). Increased MET copy number and MET overexpression are negative prognostic factors for surgically resected NSCLCs.</P>
Park, Jinwon The Society of Naval Architects of Korea 2019 International Journal of Naval Architecture and Oc Vol.11 No.1
This paper aims to assess the applicability of the Runge Kutta Discontinuous Galerkin-Direct Ghost Fluid Method to the internal explosion inside a water-filled tube, which previously was studied by many researchers in separate works. Once the explosive charge located at the inner center of the water-filled tube explodes, the tube wall is subjected to an extremely high intensity fluid loading and deformed. The deformation causes a modification of the field of fluid flow in the region near the water-structure interface so that has substantial influence on the response of the structure. To connect the structure and the fluid, valid data exchanges along the interface are essential. Classical fluid structure interaction simulations usually employ a matched meshing scheme which discretizes the fluid and structure domains using a single mesh density. The computational cost of fluid structure interaction simulations is usually governed by the structure because the size of time step may be determined by the density of structure mesh. The finer mesh density, the better solution, but more expensive computational cost. To reduce such computational cost, a non-matched meshing scheme which allows for different mesh densities is employed. The coupled numerical approach of this paper has fewer difficulties in the implementation and computation, compared to gas dynamics based approach which requires complicated analytical manipulations. It can also be applied to wider compressible, inviscid fluid flow analyses often found in underwater explosion events.
Jinwon Park 대한조선학회 2019 International Journal of Naval Architecture and Oc Vol.11 No.1
This paper aims to assess the applicability of the Runge Kutta Discontinuous Galerkin-Direct Ghost Fluid Method to the internal explosion inside a water-filled tube, which previously was studied by many researchers in separate works. Once the explosive charge located at the inner center of the water-filled tube explodes, the tube wall is subjected to an extremely high intensity fluid loading and deformed. The deformation causes a modification of the field of fluid flow in the region near the water-structure interface so that has substantial influence on the response of the structure. To connect the structure and the fluid, valid data exchanges along the interface are essential. Classical fluid structure interaction simulations usually employ a matched meshing scheme which discretizes the fluid and structure domains using a single mesh density. The computational cost of fluid structure interaction simulations is usually governed by the structure because the size of time step may be determined by the density of structure mesh. The finer mesh density, the better solution, but more expensive computational cost. To reduce such computational cost, a non-matched meshing scheme which allows for different mesh densities is employed. The coupled numerical approach of this paper has fewer difficulties in the implementation and computation, compared to gas dynamics based approach which requires complicated analytical manipulations. It can also be applied to wider compressible, inviscid fluid flow analyses often found in underwater explosion events.