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Glycan Signatures on Gastric Cancer Cells
Jihyeon Nam,Jung-A Seo,Nari Seo,Hyun Joo An 한국당과학회 2021 한국당과학회 학술대회 Vol.2021 No.01
Glycosylation, which is highly sensitive to the external environment, has been considered as a window reflecting physiological state of cell. Since abnormal glycans are a hallmark of diseases, the characterization of glycans is gaining attention in biomarker research for treatment and diagnosis. In particular, gastric cancer (GC) with various subtypes has highly different clinical results for each patient. Although gastric cancer patients are classified into different subgroups according to genetic profiling and clinical symptoms, targeted treatment is difficult. In this study, we have characterized the glycans obtained from representative GC cell lines including SNU-1, SNU-16, SNU-5, NCI-N87, AGS, KATO-Ⅲ, MNK-45 and MKN-74. In order to selectively separate the glycans located on the cell surface, the cell membrane extraction was first performed. Subsequently, glycans were enzymatically released, enriched and profiled via PGC nanoLC/MS and LC/MS/MS. Using normalized glycan intensity, a correlation among GC cell lines was examined through hierarchical analysis. The heterogeneity of each cell line was distinguished by moietise of glycans such as fucosylation, sialylation, LacdiNAc and bisecting structures. These results suggested that the glycan signatures of each cell line can differentiate GC cell lines. A deeper understanding of glycan profiling in different subtypes of gastric cancer may provide important clues for precision medicine and tumor targeted treatment.
서지현(JiHyeon Seo) 한국색채학회 2014 한국색채학회 논문집 Vol.28 No.4
연중 생산되는 절화 식물은 재배 시 환경 조건에 따라 같은 품종이더라도 색상이 다르게 나타난다. 따라서 본 연구에서는 환경 변화에 따른 자연색채의 . 변화를 알아보고, 환경에 따른 식물 색채 변화를 인식하여, 자연물 디자인에 활용하기 위해 수행되었다. 전 세계적으로 사용되는 절화의 한 종류인 장미의 6품종 ‘Propose", "Beast", "Revue", "Ocean Song", "Iguana", "Legato"를 대상으로 재배 시설 내 환경 변화와 함께 색상 변화를 분석하였다. 분석은 온도 변화가 가장 큰 여름과 겨울철, 상대적으로 생육에 적합한 환경이 유지되는 가을철에 실시하였다. 분석 결과 RP계열의 색상을 띤 ’Propose", "Revue", "Iguana" 품종의 환경 변화에 따른 색상 변화가 가장 큰 것으로 나타났으며, G계열의 ‘Beast" 품종과 PB계열의 ’Ocean Song" 품종은 상대적으로 변화가 적었다. 계절 변화와 함께 분석한 결과 고온, 다습한 여름철에 재배되어 개화한 장미의 경우 대부분의 품종에서 명도가 높아지고 채도가 낮아져, 탈색되는 경향을 보였다. 반면 상대적으로 습도가 낮고 보광으로 인한 고광 조건이 유지되는 겨울철에 재배된 장미의 경우 대부분의 품종에서 명도가 낮아지고, 채도가 높아져 색상이 선명해지는 것으로 나타났다. The cut flower produced year-round appear differently colored depending on the environmental conditions, although same cultivar. This study was analyzed environment changes in greenhouse and the color changes of cut flower due to investigate natural color changes by environmental condition. The analysis targets were choose Rosa hybrida used such as "Propose", "Beast", "Revue", Ocean Song", "Iguana", "Legato". Environment analysis was carried out in summer and winter which the greatest temperature changes, also it was done in autumn which maintained environment for the growth. The results of analysis of color changes was show that greatest change in "Propose", "Revue", "Iguana" with RP color. But "Beast" of G and "Ocean Song" of PB relatively less variation. Additionally, rose of most cultivars grown in the high temperature and humid of summer were lower saturation and higher.
Kuen, Jihyeon,Woo, Eung Je,Seo, Jin Keun IOP Pub 2009 PHYSIOLOGICAL MEASUREMENT Vol.30 No.6
<P>We evaluated the performance of the lately developed electrical impedance tomography (EIT) system KHU Mark1 through time-difference imaging experiments of canine and human lungs. We derived a multi-frequency time-difference EIT (mftdEIT) image reconstruction algorithm based on the concept of the equivalent homogeneous complex conductivity. Imaging experiments were carried out at three different frequencies of 10, 50 and 100 kHz with three different postures of right lateral, sitting (or prone) and left lateral positions. For three normal canine subjects, we controlled the ventilation using a ventilator at three tidal volumes of 100, 150 and 200 ml. Three human subjects were asked to breath spontaneously at a normal tidal volume. Real- and imaginary-part images of the canine and human lungs were reconstructed at three frequencies and three postures. Images showed different stages of breathing cycles and we could interpret them based on the understanding of the proposed mftdEIT image reconstruction algorithm. Time series of images were further analyzed by using the functional EIT (fEIT) method. Images of human subjects showed the gravity effect on air distribution in two lungs. In the canine subjects, the morphological change seems to dominate the gravity effect. We could also observe that two different types of ventilation should have affected the results. The KHU Mark1 EIT system is expected to provide reliable mftdEIT images of the human lungs. In terms of the image reconstruction algorithm, it would be worthwhile including the effects of three-dimensional current flows inside the human thorax. We suggest clinical trials of the KHU Mark1 for pulmonary applications.</P>
어머니-영아의 기질적 조화적합성 예측요인에 관한 연구: 어머니-영아 상호작용, 어머니 양육지식, 영아 발달 및 COVID-19 시기 가정양육환경을 중심으로
서소정 ( Seo Sojung ),이지현 ( Lee Jihyeon ),송지연 ( Song Jiyeon ) 한국유아교육학회 2023 유아교육연구 Vol.43 No.3
본 연구는 어머니-영아의 기질적 조화적합성 수준에 따른 집단 간 어머니-영아 상호작용, 어머니 양육지식, 영아 발달 및 COVID-19 시기 가정양육환경의 차이와 어머니-영아 조화적합성 예측요인을 규명하고, 어머니-영아 간의 상호작용 관련 질적 특성을 심층적으로 살펴보고자 하였다. 이를 위해 서울·경기 어린이집에 재원하는 영아와 어머니 50쌍을 대상으로 설문조사 및 현장관찰을 통해 양적·질적 자료를 수집하였다. 수집된 자료를 통해 어머니-영아의 기질적 조화적합성 수준에 따른 세 집단별(상, 중, 하) 주요 연구변인의 차이 및 집단분류 예측요인을 살펴보고 각 집단을 대표하는 9쌍을 대상으로 어머니-영아 상호작용의 특성을 심층적으로 분석하였다. 그 결과, 어머니-영아의 기질적 조화적합성은 연구대상의 인구사회학적 배경 및 주요 연구변인에 유의한 차이를 보였으며, 이를 예측하는 변인은 어머니 상호작용 및 영아 발달로 나타났다. 또한 각 집단의 어머니-영아 상호작용 질적 특성에 있어 유사성 및 차이점이 나타나, 양적 결과를 어느 정도 지지하는 것으로 나타났다. 본 연구는 어머니-영아의 기질적 조화적합성 관련 연구 및 자녀 양육 실제에 유용한 기초자료를 제공한 점에서 의의가 있다. The main purpose of this study was to differences in mother-infant temperamental goodness of fit as related to mother-infant interaction, mother’s parenting knowledge, infant development, and infant-rearing home environment during the COVID-19 period and examined in-depth the qualitative characteristics of mother-infant interaction. To this end, quantitative and qualitative data were collected through surveys and on-site observations of 50 mother-infant dyad who attended subsidized child care facilities, located in Seoul and Gyeonggi areas. From the collected data, we examined the differences between the three main study variables and group classification predictors according to the mother-infant temperamental goodness of fit and analyzed the characteristics of nine pairs of mother-infant interaction representing each group. The results of the mother-infant temperamental goodness of fit showed significant differences in the demographic background and major research variables of the study, and the variables predicting this were mother interaction and infant development. Also, results from the statistical findings to show that there were both common and group-specific patterns in associations with mother-infant interaction. Along with the main results of this study, implications for research and practice were discussed.