http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Evolution of Pathophysiological Knowledge in Atopic Dermatitis
( Hiroyuki Murota ) 한국피부장벽학회 2021 한국피부장벽학회지 Vol.23 No.2
Impaired homeostasis in the atopic epidermis can cause skin barrier damage, inflammation, and pruritus. We have researched the mechanisms of impaired skin homeostasis and have gained new insights into the role of the epidermal barrier, dermato-endocrinology, and sweating. Expression of claudin-1, a component of epidermal tight junctions, is decreased in atopic dermatitis (AD), resulting in increased epidermal barrier permeability. We generated knockdown mice in which the expression of claudin-1 was reduced to several different levels and observed that the phenotypes of augmented epidermal permeability, xerosis, hair loss, and innate immune activity were associated with decreasing expression of claudin-1, indicating that the expression level of claudin-1 influences disease severity. We also investigated abnormally reduced activation of endogenous glucocorticoids via the enzyme 11 beta-hydroxysteroid dehydrogenase-1 (HSD11b1) in the atopic epidermis. Keratinocyte-specific HSD11b1-knockout mice were hypersensitive to light touch-evoked itch and low concentrations of haptens, suggesting that reduced expression of HSD11b1 is important in the pathogenesis of irritant susceptibility and alloknesis in the atopic epidermis. This last finding is also related to sweat. Although sweat maintains skin homeostasis, its composition in AD is altered, with the glucose concentration increasing as disease severity increases, and impairs the recovery function of the skin barrier. Sweat glucose decreases as dermatitis improves; therefore, AD patients will improve their sweat by treating their dermatitis.
이정범,신영오,Hiroyuki Murota 한국식품영양과학회 2015 Journal of medicinal food Vol.18 No.5
Oligonol is a low-molecular-weight polyphenol that possesses antioxidant and anti-inflammatory properties. This study investigated the effects of Oligonol supplementation on sweating response, plasma volume (PV), and osmolality (Osm) after heat load in human volunteers. We conducted a placebo-controlled crossover trial. Participants took a daily dose of 200 mg Oligonol or placebo for 1 week. After a 2-week washout period, the subjects were switched to the other study arm. As a heat load, half-body immersion into hot water (42℃ ± 0.5℃ for 30 min) was performed in an automated climate chamber. Tympanic and mean body temperature (Tty, mTb) and whole-body sweat loss volume (WBSLV) were measured. Changes in PV, Osm, and serum levels of aldosterone and sodium were analyzed. Oligonol intake attenuated increases in Tty, mTb, and WBSLV after heat load compared with the placebo (P < .01, P < .05, and P < .01, respectively). In addition, serum aldosterone was maintained at a relatively low degree and serum sodium was maintained at a relatively high degree with Oligonol compared to the placebo (P < .01 and P < .05, respectively). However, PV decreased and Osm increased significantly with Oligonol compared to the placebo (P < .05 and P < .05, respectively). This study demonstrates that Oligonol supplementation for 1 week can attenuate elevation of body temperature and excessive sweating under heat load in healthy humans, but interpretation of the results requires caution due to the potent diuretic effect of Oligonol.
Morphea on the Breast after a Needle Biopsy
Noriko Arase,Ken Igawa,Satoko Senda,Mika Terao,Hiroyuki Murota,Ichiro Katayama 대한피부과학회 2011 Annals of Dermatology Vol.23 No.-
Localized scleroderma (morphea) usually develops spontaneously,but the precise mechanisms underlying disease development are obscure. However, a significant number of cases suggest that morphea is induced by external stimuli. Herein, we report a case of morphea that developed after a needle biopsy. (Ann Dermatol 23(S3) S408∼S410, 2011)
Case Reports : Morphea on the Breast after a Needle Biopsy
( Noriko Arase ),( Ken Igawa ),( Satoko Senda ),( Mika Terao ),( Hiroyuki Murota ),( Ichiro Katayama ) 대한피부과학회 2011 Annals of Dermatology Vol.23 No.3s
Localized scleroderma (morphea) usually develops spontaneously, but the precise mechanisms underlying disease development are obscure. However, a significant number of cases suggest that morphea is induced by external stimuli. Herein, we report a case of morphea that developed after a needle biopsy. (Ann Dermatol 23(S3) S408~S410, 2011)
( Saori Itoi ),( Atsushi Tanemura ),( Mamori Tani ),( Shun Kitaba ),( Mika Terao ),( Hiroyuki Murota ),( Naoki Oiso ),( Ichiro Katayama ) 대한피부과학회 2014 Annals of Dermatology Vol.26 No.2
Background: Peculiar erythema known as annular erythema associated with Sjogren`s syndrome (AESS) can be differentiated from autoimmune annular erythema and subacute cutaneous lupus erythematosus, both clinically and histologically. However, there are no detailed investigations on immune competent cells infiltration. Objective: Preferential infiltration of interleukin-17-producing T helper (Th17) cells and regulatory T (Treg) cells into the labial salivary gland is reported to play a role in maintaining mucoepithelitis in patients with Sjogren`s syndrome. In this study, we evaluated Th17 and Treg cell infiltration into the lesional skin of AESS. Methods: We analyzed the numbers and infiltration patterns of Th17 and FoxP3 (+) Treg cells in seven cases of AESS using immunohistochemistry. Seven patients with systemic lupus erythematosus (SLE), atopic dermatitis (AD) and psoriasis vulgaris (PV), which are representatives of Th17 cell-involved skin disorders, were enrolled as disease controls. Results: Periappendageal and epidermal changes, such as follicular plugging and liquefaction, were evident in the annular erythema of SLE, not AESS, tissue samples. In AESS tissue samples, dense perivascular and periappendageal in-filtration of lymph cells was observed in the middle-to-deep dermis, as previously described, in contrast to the superficial infiltration pattern observed in both AD and PV samples. While the total number of infiltrated lymphocytes was similar between AESS and SLE tissue samples, Th17 cells were found to be preferentially infiltrated in the middle- to-deep dermis in AESS samples. Conclusion: These results suggest that an increased number and distribution of infiltration of Th17 cells is a preferential feature of AESS, rather than a characteristic feature of annular erythema of SLE.