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Permeability imaging in granitic rocks based on surface resistivity profiling
Sudo Hiroshi,Tanaka Toshikazu,Kobayashi Tsuyoshi,Kondo Tatsutoshi,Takahashi Toru,Miyamoto Masaharu,Amagai Mitsuru Korean Society of Earth and Exploration Geophysici 2004 지구물리와 물리탐사 Vol.7 No.1
In order to image the distribution of permeability in granitic rocks, we carried out two-dimensional (2D) resistivity profiling, together with in-situ permeability tests, electrical logging of boreholes, and resistivity measurements of rock core samples in a laboratory. Based on the electrical logging and in-situ permeability data from boreholes, we obtained empirical equations which relate resistivity and permeability of the granitic rocks in the area studied. We then applied the empirical equation to a 2D resistivity section, to produce a 2D permeability section of the granitic rocks. In this paper, we present details of the field data and of the procedure for conversion from the resistivity section to a permeability section. The observed relationship between resistivity and permeability of the rocks is also discussed.
Shu Yazaki,Yuki Kojima,Hiroshi Yoshida,Shigemasa Takamizawa,Rui Kitadai,Tadaaki Nishikawa,Tatsunori Shimoi,Kazuki Sudo,Ayumi Saito,Hitomi Sumiyoshi Okuma,Maki Tanioka,Emi Noguchi,Masaya Uno,Mitsuya Is 대한부인종양학회 2022 Journal of Gynecologic Oncology Vol.33 No.6
Objective: Folate receptor α (FRα) is a membrane protein expressed in various solid tumors but has limited expression in normal cells. Therefore, FRα is an attractive target for cancer treatment. This study aimed to investigate the relationship between FRα expression and the clinicopathological characteristics and survivals of cervical cancer. Methods: This retrospective study included patients with cervical cancer who underwent primary surgery between 2000 and 2020 at our institution. Immunohistochemical staining of FRα was performed using an anti-folate-binding protein/FBP antibody. FRα-positive staining was defined as ≥5% of tumor staining and FRα-high as ≥50% tumor staining with ≥2+ intensity. The association between FRα expression and survival was assessed using multivariate Cox regression analysis, adjusting for established prognostic factors. Results: Overall, 123 patients were identified, and 140 tumor samples, including 17 paired primary and metastatic samples, were evaluated. As histological types, 67 patients had squamous cell carcinoma (SCC), and 56 patients had non-SCC. All primary tumors were FRα-positive. High FRα expression was observed in 25% of the cases and differed according to histology (SCC vs. non-SCC, 14.9% vs. 37.5%, p=0.004). FRα expression was significantly higher in metastatic tumors than in primary (170 [IQR, 140–205] vs. 125 [IQR, 110–150], p=0.0006). High FRα expression was significantly associated with worse overall survival (hazard ratio, 6.73; 95% confidence interval, 2.21–20.53; p=0.001). Conclusion: In cervical cancer, FRα expression was elevated in metastatic tumors and high expression was associated with a worse prognosis. Our study supports the development of FRα-targeted therapy for advanced cervical cancer.