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      • Estimating Point-of-View-based Similarity using POV Reinforcement and Similarity Propagation

        ( Kenji Nagamatsu ),( Hidehiko Tanaka ) 한국언어정보학회 1996 국제 워크샵 Vol.1996 No.-

        This paper proposes a similarity measure which takes account of point-of-views (abbreviated to POV, hereafter) in the calculation of similarity values. So far many researches on similarity measures have been per-formed but none takes account of POVs. The similarity measure pro-posed in this paper is based on co-occurrence probabilities of words and this makes it possible to obtain preferable precision even if POVs are not given. This method consists of two parts of processes, POV reinforce-ment and similarity propagation. First, the POV reinforcement process, which affects the similarity between words, modifies the weights of links according to the relatedness between the link and the POV word. Sec-ond, the similarity propagation process propagates the weights of links and defines a similarity value for word pairs which do not actually co-occur in the corpus. Using those two processes this method becomes capable both to take POVs into consideration and to cope with the sparseness of corpora to some degree. This paper, however, focuses on the POV reinforcement and evaluates the effectiveness of the method.

      • Reduction of Intestinal Polyp Formation in Min Mice Fed a High-Fat Diet with Aloe Vera Gel Extract

        Chihara, Takeshi,Shimpo, Kan,Beppu, Hidehiko,Tomatsu, Akiko,Kaneko, Takaaki,Tanaka, Miyuki,Yamada, Muneo,Abe, Fumiaki,Sonoda, Shigeru Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.7

        Aloe vera gel supercritical $CO_2$ extract (AVGE) has been shown to contain five phytosterols, reduce visceral fat accumulation, and influence the metabolism of glucose and lipids in animal model experiments. Recent epidemiologic studies have shown that obesity is an established risk factor for several cancers including colorectal cancer. Therefore, we examined the effects of AVGE on intestinal polyp formation in Apc-deficient Min mice fed a high-fat diet. Male Min mice were divided into normal diet (ND), high fat diet (HFD), low dose AVGE (HFD+LAVGE) and high dose AVGE (HFD+HAVGE) groups. The ND group received AIN-93G diet and the latter 3 groups were given modified high-fat AIN-93G diet (HFD) for 7 weeks. AVGE was suspended in 0.5% carboxymethyl cellulose (CMC) and administered orally to mice in HFD+LAVGE and HFD+HAVGE groups every day (except on Sunday) for 7 weeks at a dose of 3.75 and 12.5 mg/kg body weight, respectively. ND and HFD groups received 0.5% CMC alone. Between weeks 4 and 7, body weights in the HFD and HFD+LAVGE groups were reduced more than those in the ND group. However, body weights were not reduced in the HFD+HAVGE group. Mice were sacrificed at the end of the experiment and their intestines were scored for polyps. No significant differences were observed in either the incidence and multiplicity of intestinal polyps (${\geq}0.5$ mm in a diameter) among the three groups fed HFD. However, when intestinal polyps were categorized by their size into 0.5-1.4, 1.5-2.4, or ${\geq}2.5$ mm, the incidence and multiplicity of large polyps (${\geq}2.5$ mm) in the intestine in the HFD+HAVGE group were significantly lower than those in the HFD group. We measured plasma lipid (triglycerides and total cholesterol) and adipocytokine [interleukin-6 and high molecular weight (HMW) adiponectin] levels as possible indicators of mechanisms of inhibition. The results showed that HMW adiponectin levels in the HFD group were significantly lower than those in the ND group. However, the levels in the HFD+HAVGE group were significantly higher than those in the HFD group. These results indicate that HAVGE reduced large-sized intestinal polyps and ameliorated reduction in plasma HMW adiponectin levels in Min mice fed HFD.

      • Low temperature sintering of nano-SiC using a novel Al<sub>8</sub>B<sub>4</sub>C<sub>7</sub> additive

        Lee, Sea-Hoon,Kim, Byung-Nam,Tanaka, Hidehiko Cambridge University Press (Materials Research Soc 2010 Journal of materials research Vol.25 No.3

        <P>Al8B4C7 was used as a sintering additive for the densification of nano-SiC powder. The average grain size was approximately 70 nm after sintering SiC-12.5wt% Al8B4C7 at 1550 °C. The densification rate strongly depended on the sintering temperature and the applied pressure. The rearrangement of SiC particles occurred at the initial shrinkage, while viscous flow and liquid phase sintering became important at the middle and final stage of densification.</P>

      • Dietary Aloe Vera Gel Powder and Extract Inhibit Azoxymethane-induced Colorectal Aberrant Crypt Foci in Mice Fed a High-fat Diet

        Chihara, Takeshi,Shimpo, Kan,Kaneko, Takaaki,Beppu, Hidehiko,Higashiguchi, Takashi,Sonoda, Shigeru,Tanaka, Miyuki,Yamada, Muneo,Abe, Fumiaki Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.2

        Aloe vera gel exhibits protective effects against insulin resistance as well as lipid-lowering and anti-diabetic effects. The anti-diabetic compounds in this gel were identified as Aloe-sterols. Aloe vera gel extract (AVGE) containing Aloe-sterols has recently been produced using a new procedure. We previously reported that AVGE reduced large-sized intestinal polyps in Apc-deficient Min mice fed a high fat diet (HFD), suggesting that Aloe vera gel may protect against colorectal cancer. In the present study, we examined the effects of Aloe vera gel powder (AVGP) and AVGE on azoxymethane-induced colorectal preneoplastic aberrant crypt foci (ACF) in mice fed a HFD. Male C57BL/6J mice were given a normal diet (ND), HFD, HFD containing 0.5% carboxymethyl cellulose solution, which was used as a solvent for AVGE (HFDC), HFD containing 3% or 1% AVGP, and HFDC containing 0.0125% (H-) or 0.00375% (L-) AVGE. The number of ACF was significantly lower in mice given 3% AVGP and H-AVGE than in those given HFD or HFDC alone. Moreover, 3% AVGP, H-AVGE and L-AVGE significantly decreased the mean Ki-67 labeling index, assessed as a measure of cell proliferation in the colonic mucosa. In addition, hepatic phase II enzyme glutathione S-transferase mRNA levels were higher in the H-AVGE group than in the HFDC group. These results suggest that both AVGP and AVGE may have chemopreventive effects on colorectal carcinogenesis under the HFD condition. Furthermore, the concentration of Aloe-sterols was similar between 3% AVGP and H-AVGE, suggesting that Aloe-sterols were the main active ingredients in this experiment.

      • Corrosion behavior of volcanic ash on sintered mullite for environmental barrier coatings

        Jang, Byung-Koog,Feng, Fan-Jie,Suzuta, Keiko,Tanaka, Hidehiko,Matsushita, Yoshitaka,Lee, Kee Sung,Kim, Seongwon,Oh, Yoon-Suk,Kim, Hyung-Tae Elsevier 2017 CERAMICS INTERNATIONAL Vol.43 No.2

        <P><B>Abstract</B></P> <P>The high-temperature corrosion behavior of volcanic ash(VA) in attacking sintered mullite was investigated, and the corrosion resistibility of mullite environmental barrier coatings (EBCs) to VA was predicted. Sintered mullite specimens were prepared by using the spark plasma sintering method. These specimens were subjected to a hot corrosive environment—molten Icelandic VA at 1400°C—for three different duration times (2, 12, and 48h). The microstructure and phase of the specimens were analyzed by using a scanning electron microscope equipped with an accessory system for energy dispersive spectroscopy and X-ray diffraction. In addition, <I>in-situ</I> high-temperature X-ray diffraction was carried out to identify the dynamics of phase evaluation in the volcanic ash and mullite mixture powders. Results show that a reaction layer was generated and continuously dissolved into the melted volcanic ash. The primary incursive component is iron; however, a minimal amount of sodium plays a more important role in disintegrating sintered mullite.</P>

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