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Xu Hao,Yuebo Yuan,Hewu Wang,Tiegang Hu,Sisi Ji,Yin Wang 한국자동차공학회 2022 International journal of automotive technology Vol.23 No.5
Owing to the lockdowns associated with the Coronavirus Disease 2019(COVID-19) pandemic, carbon emissions were significantly reduced. However, the accurate impacts on the personal transport sector since then remain unclear. To further investigate the influence of sudden public health emergencies on actual carbon emissions from personal electric vehicles, this paper examined the travel patterns and corresponding carbon emissions of plug-in hybrid electric vehicles (PHEVs) operating in Chongqing, China, before and after COVID-19. The results revealed that the pandemic has reshaped the travel patterns of vehicle drivers, with a 9 % reduction in the postpandemic fleet average daily travel mileage. Currently, the total daily carbon emissions of a PHEV with a range of 80 km (PHEV80) are 6.24 kg, which is 13 % lower than emissions from conventional vehicles and 32 % higher than those from electric battery-powered vehicles before the pandemic. Since COVID-19, there has been a 24 % decrease in carbon emissions from PHEV80 vehicles for the fleet and a 30 % maximum increase for individuals. Furthermore, considering the integration of 50 % renewable energy into China’s power grid by 2025, PHEVs can better mitigate the fluctuations in carbon emissions associated with sudden public health emergencies compared with conventional vehicles.
The Combination of Gefitinib and Acetaminophen Exacerbates Hepatotoxicity via ROS-Mediated Apoptosis
Xu Jiangxin,Huang Xiangliang,Zhou Yourong,Xu Zhifei,Cai Xinjun,Yang Bo,He Qiaojun,Luo Peihua,Yan Hao,Jin Jie 한국응용약물학회 2024 Biomolecules & Therapeutics(구 응용약물학회지) Vol.32 No.5
Gefitinib is the well-tolerated first-line treatment of non-small cell lung cancer. As it needs analgesics during oncology treatment, particularly in the context of the coronavirus disease, where patients are more susceptible to contract high fever and sore throat. This has increased the likelihood of taking both gefitinib and antipyretic analgesic acetaminophen (APAP). Given that gefitinib and APAP overdose can predispose patients to liver injury or even acute liver failure, there is a risk of severe hepatotoxicity when these two drugs are used concomitantly. However, little is known regarding their safety at therapeutic doses. This study simulated the administration of gefitinib and APAP at clinically relevant doses in an animal model and confirmed that gefitinib in combination with APAP exhibited additional hepatotoxicity. We found that gefitinib plus APAP significantly exacerbated cell death, whereas each drug by itself had little or minor effect on hepatocyte survival. Mechanistically, combination of gefitinib and APAP induces hepatocyte death via the apoptotic pathway obviously. Reactive oxygen species (ROS) generation and DNA damage accumulation are involved in hepatocyte apoptosis. Gefitinib plus APAP also promotes the expression of Kelch-like ECH-associated protein 1 (Keap1) and downregulated the antioxidant factor, Nuclear factor erythroid 2-related factor 2 (Nrf2), by inhibiting p62 expression. Taken together, this study revealed the potential ROS-mediated apoptosis-dependent hepatotoxicity effect of the combination of gefitinib and APAP, in which the p62/Keap1/Nrf2 signaling pathway participates and plays an important regulatory role.
Regional Science and Technology Resource Allocation Optimization Based on Improved Genetic Algorithm
( Hao Xu ),( Lining Xing ),( Lan Huang ) 한국인터넷정보학회 2017 KSII Transactions on Internet and Information Syst Vol.11 No.4
With the advent of the knowledge economy, science and technology resources have played an important role in economic competition, and their optimal allocation has been regarded as very important across the world. Thus, allocation optimization research for regional science and technology resources is significant for accelerating the reform of regional science and tech-nology systems. Regional science and technology resource allocation optimization is modeled as a double-layer optimization model: the entire system is characterized by top-layer optimi-zation, whereas the subsystems are characterized by bottom-layer optimization. To effica-ciously solve this optimization problem, we propose a mixed search method based on the orthogonal genetic algorithm and sensitivity analysis. This novel method adopts the integrated modeling concept with a combination of the knowledge model and heuristic search model, on the basis of the heuristic search model, and simultaneously highlights the effect of the knowledge model. To compare the performance of different methods, five methods and two channels were used to address an application example. Both the optimized results and simu-lation time of the proposed method outperformed those of the other methods. The application of the proposed method to solve the problem of entire system optimization is feasible, correct, and effective.
Xu, Hao,Mei, Xiao-Peng,Xu, Li-Xian The Korean Dental Society of Anesthsiology 2018 Journal of Dental Anesthesia and Pain Medicine Vol.18 No.1
In recent years, with continuous research efforts targeted at studying the effects of pre- and after-treatment of inhaled anesthetics, significant progress has been made regarding the common clinical use of low concentrations of inhaled sevoflurane and its effect on induced central ischemia tolerance by pre- and post-treatment. In this study, we collected, analyzed, classified, and summarized recent literature regarding the effect of sevoflurane on central ischemia tolerance and its related mechanisms. In addition, we provide a theoretical basis for the clinical application of sevoflurane to protect the central nervous system and other important organs against ischemic injury.
Hao Xu,GUOHUA LUO 한국공업화학회 2018 Journal of Industrial and Engineering Chemistry Vol.65 No.-
This review gives a summary on heterogeneous non-mercury catalysts for acetylene hydrochlorination process. First, various catalysts are classified and their performances are compared. Next, studies on catalytic performance by theoretical characterizations and molecule level simulations are introduced. Then, efforts for industrial scaling up and corresponding long-term plant trial results are presented to show enormous potential of state-of-the-art catalysts. Finally, the crucial engineering issues for future industrialization process including kinetic study, reactor design & simulation and material recycling process are proposed. Based on promising achievements, we believe that extensive industrial application of non-mercury catalysts for acetylene hydrochlorination will soon become reality.
Xu, Hao,Wise, John H.,Norman, Michael L.,Ahn, Kyungjin,O’Shea, Brian W. American Astronomical Society 2016 The Astrophysical journal Vol.833 No.1
<P>Cosmic reionization is thought to be primarily fueled by the first generations of galaxies. We examine their stellar and gaseous properties, focusing on the star formation rates and the escape of ionizing photons, as a function of halo mass, redshift, and environment using the full suite of the Renaissance Simulations with an eye to provide better inputs to global reionization simulations. This suite probes overdense, average, and underdense regions of the universe of several hundred comoving Mpc(3), each yielding a sample of over 3000 halos in the mass range of 10(7)-10(9.5)M(circle dot) at their final redshifts of 15, 12.5, and 8, respectively. In the process, we simulate the effects of radiative and supernova feedback from 5000 to 10,000 Population III stars in each simulation. We find that halos as small as 10(7) M-circle dot are able to host bursty star formation due to metal-line cooling from earlier enrichment by massive Population III stars. Using our large sample, we find that the galaxy-halo occupation fraction drops from unity at virial masses above 10(8.5) M-circle dot to similar to 50% at 10(8) M-circle dot and similar to 10% at 10(7) M-circle dot, quite independent of redshift and region. Their average ionizing escape fraction is similar to 5% in the mass range of 10(8)-10(9) M-circle dot and increases with decreasing halo mass below this range, reaching 40%-60% at 10(7) M-circle dot. Interestingly, we find that the escape fraction varies between 10%-20% in halos with virial masses of similar to 3 x 10(9) M-circle dot. Taken together, our results confirm the importance of the smallest galaxies as sources of ionizing radiation contributing to the reionization of the universe.</P>