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RISS 인기검색어
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- 저자 : ( Guofang Liu ) (검색결과 4 건)
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Yan Liu,Guofang Hou,Xiaobei Zhang,Jing Jing Liu,Sheng Zhang,Jin Zhang 한국유방암학회 2014 Journal of breast cancer Vol.17 No.2
Purpose: This study investigated the additive effect of photodynamictherapy (PDT) plus traditional radiotherapy (RT) for patientswith breast cancer and chest wall recurrence. Methods: Atotal of 40 patients with recurrent breast cancer were prospectivelyrandomized to receive RT alone (group A, n=20) or PDTand RT in combination (group B, n=20). Traditional RT at a doseof 50 Gy was delivered in 25 fractions with or without exposureto 5-aminolevulinic acid and red light as PDT. Results: The responserates were not statistically different between the groups,but more patients achieved a complete response (CR) in groupB (50%) than in group A (20%). The median time to CR in groupB was significantly shorter than that in group A (109.6 days vs. 175.2 days, p=0.001). Adverse event profiles were not differentbetween the groups. Conclusion: An additive antitumor effect isdemonstrated with additional PDT to RT. This combination therapymight reduce the duration of exposure to RT, but further investigationis warranted.
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Macro-Micro Mechanical Behavior of Crushable Granular Materials under Generalized Stress Conditions
Yiming Liu,Chenming Xu,Guofang Xu,Haijun Mao,Zunqun Xiao 대한토목학회 2021 KSCE JOURNAL OF CIVIL ENGINEERING Vol.25 No.5
This paper investigated the joint influence of particle crushing and intermediate principal stress coefficient on the macro and micro performances of granular assembles by using 3D discrete element method. The soil particle was modeled by crushable agglomerate. Numerical true triaxial tests with crushable agglomerates were performed. The mechanical behaviors of specimens with unbreakable agglomerates were also tested in this study. The results demonstrated that grain breakage can significantly affect the behaviors of granular soils in both macro and micro scales. Moreover, the present paper also showed that particle breakage did not influence the unique relationship between the intermediate principal stress coefficient band the deviatoric fabric of strong contacts. This can provide a good basis for developing micro-parameter-based constitutive model considering particle breakage for granular soils.
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MiR-371 promotes proliferation and metastasis in hepatocellular carcinoma by targeting PTEN
( Hao Wang ),( Yi Zhao ),( Tingsong Chen ),( Guofang Liu ),( Nan He ),( Heping Hu ) 생화학분자생물학회(구 한국생화학분자생물학회) 2019 BMB Reports Vol.52 No.5
Hepatocellular carcinoma (HCC) is the leading cause of cancer-related mortality worldwide. MiR-371 has recently emerged as an important regulator in tumorigenesis, and may serve as a biomarker for malignant tumors. We transfected miR-371 or its inhibitor in two human HCC cell lines, then used 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide, soft agar colony formation, and transwell migration assays to evaluate the effects on cell proliferation, migration, and invasion. We found that miR-371 was positively correlated with HCC metastasis and poor prognosis in the inflicted patients, and the high expression of miR-371 was promoted, whereas a low level of miR-371 depressed cell proliferation and invasion. We found PTEN to be a direct target of miR-371. The overexpression or knockdown of PTEN exhibited the opposite effects from those of miR-371 on cell proliferation and migration. Our study demonstrates that miR-371 promotes proliferation and metastasis in HCC by targeting PTEN. [BMB Reports 2019; 52(5): 312-317]
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Making Line Undercut Structure by Incremental Laser Shock Forming
Shuxin You,Xiangying Wang,Zhong Ji,Chao Zheng,Guofang Zhang,Ren Liu 한국정밀공학회 2019 International Journal of Precision Engineering and Vol.20 No.8
A novel technology to plastically deform line undercut structures by pulsed laser, named as incremental laser shock forming (ILSF) of sheet metal, is presented in this paper and is investigated by experiments and numerical simulations. The deformation of a line undercut structure can be considered as the accumulation of several point undercuts, the shape evolution during ILSF of copper foils was observed, and the thickness distribution on a cross-section was measured. The influences of laser energy E, forming height H, and laser spot overlap rate η on the process were studied and a process window was established to avoid deformation failure. The results show that the plastic deformation at η = 0% is less uniform and more vulnerable than that at η = 50%. Three typical failure modes were concluded and discussed. Finite element method simulation was conducted to verify the feasibility of forming line undercut structure by ILSF, and to analyze its deformation mechanism.
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