http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Sul, Dong-Geun,Oh, Sang-Nam,Lee, Eun-Il The Korean Society of Toxicogenomics and Toxicopro 2008 Molecular & cellular toxicology Vol.4 No.1
Long term exposure of Jurkat cells to 2 ATA pressure resulted in the inhibition of cell growth. Under a 2 ATA pressure, the morphological changes in the cells were visualized by electron microscopy. The cells exhibited significant inhibitory responses after three passages. However, short-term exposure study was carried out, 2 ATA pressure may have beneficial effects. The Jurkat cells were exposed to $H_2O_2$ (25 and $50{\mu}M$) in order to induce DNA damage, and then incubated under at either normal pressure or 2 ATA for 1 or 2 hours in order to recover the DNA damage. The extent of DNA damage was determined via Comet assay. More recovery from DNA damage was observed at 2 ATA than at normal pressure. The activity of the DNA repair enzymes, DNA polymerase-$\beta$, was also evaluated at both normal pressure and 2 ATA. The activity of DNA polymerase-$\beta$ was observed to have increased significantly at the 2 ATA than at normal pressure. In conclusion, the effects of hyperbaric pressure from 1 ATA to 2 ATA on biochemical systems can be either beneficial or harmful. Long term exposure to hyperbaric pressure clearly inhibited cell proliferation and caused genotoxic effects, but short-term exposure to hyperbaric pressure proved to be beneficial in terms of bolstering the DNA repair system. The results of the present study have clinical therapeutic application, and might prove to be an useful tool in the study of genotoxicity in the future.
( Geun Dong Sul ),( Hyun Jung Park ),( Jong Hwan Bae ),( Keum Duck Hong ),( Byeong Deog Park ),( Jaesun Chun ),( Se Kyoo Jeong ),( Seung Hun Lee ),( Sung Ku Ahn ),( Hyun Jung Kim ) 대한피부과학회 2013 Annals of Dermatology Vol.25 No.1
Background: Topical steroid treatment induces diverse local Wand systemic adverse effects. Several approaches have been tried to reduce the steroid-induced adverse effects. Simultaneous application of physiological lipid mixture is also suggested. Objective: Novel vehicles for topical glucocorticoids formulation were evaluated for the efficacy of reducing side-effects and the drug delivery properties of desonide, a low potency topical steroid. Methods: Transcutaneous permeation and skin residual amount of desonide were measured using Franz diffusion cells. The in vivo anti-inflammatory activity was evaluated using murine model. Results: Topical steroids formulation containing desonide, in either cream or lotion form, were prepared using multi-lamellar emulsion (MLE), and conventional desonide formulations were employed for comparison. MLE formulations did not affect the anti-inflammatory activity of the desonide in phobol ester-induced skin inflammation model, compared with conventional formulations. While the penetrated amounts of desonide were similar for all the tested formulations at 24 hours after application, the increased lag time was observed for the MLE formulations. Interestingly, residual amount of desonide in epidermis was significantly higher in lotion type MLE formulation. Steroid-induced adverse effects, including permeability barrier function impairment, were partially prevented by MLE formulation. Conclusion: Topical desonide formulation using MLE as a vehicle showed a better drug delivery with increased epidermal retention. MLE also partially prevented the steroid-induced side effects, such as skin barrier impairment. (Ann Dermatol 25(1) 5∼11, 2013)
DNA damage in T- and B-lymphocytes of rats exposed to benzene
Sul, Dong-Geun,Lee, Do-Young,Jo, Gyu-Chan,Im, Ho-Sub,Hong, Hyun-Ho,Jo, Duk-Jin,Kim, Chan-Wha,Kim, Hae-Joon,Lee, Eun-Il Korean Environmental Mutagen Society 2002 한국환경성돌연변이·발암원학회지 Vol.22 No.4
Single cell gel electrophoresis assay was carried out to evaluate DNA damage in T-and B-lymphocytes from rats exposed to benzene and the correlation between DNA damage and the level of t,t-muconic acids, which are urinary benzene metabolites, was investigated. In control rats, the mean values of Olive tail moments in T-and B-lymphocytes were 1.507$\pm$0.187 and 1.579$\pm$0.206 respectively. DNA damages of T-lymphocytes in rats exposed for 4 weeks showed the highest Olive tail moments at each benzene concentration examined (2.72-4.351). However this DNA damage was decreased after 6 weeks of exposure (1.74-2.09). DNA damages of B-lymphocytes did not show such differences with exposure time or benzene concentration (1.49-2.07) except at 200 ppm at 4 weeks. T-lymphocytes show significantly more damages than B-lymphocyte upon acute exposure to benzene.
알레르기접촉피부염 환자(영서지역, 2005~2010년)의 첩포검사(TRUE Test) 결과에 관한 고찰
설근동 ( Geun Dong Sul ),이성율 ( Sung Yul Lee ),김재홍 ( Jae Hong Kim ),홍한나 ( Han Nah Hong ),천재순 ( Jae Sun Chun ),안성구 ( Sung Ku Ahn ) 대한피부과학회 2011 대한피부과학회지 Vol.49 No.7
Background: Since 2005, the commercial patch test panel, the TRUE-test, has been available. However, there have been no reports regarding the results of the TRUE-test compared with previously used Korean Standard Series in Korea. Objective: This study aimed to evaluate the prevalence of the contact allergy, causative allergens, and source of allergens in patients who were diagnosed with allergic contact dermatitis, and to compare the findings with previously used Korean Standard Series. Methods: We reviewed the results of the TRUE-test from 2005~2010 in Wonju Christian Hospital. We patch-tested 843 patients who were diagnosed with allergic contact dermatitis. The patch test reading was performed on day 2 and days 3 or 4, according to the patients` needs. Epidemiologic findings of patients and the results of the patch tests were analyzed. Results: A total of 843 patch-tested cases were compiled and analyzed. Of 843 patch-tested patients (male, 309; female, 534), 65.8% had at least 1 positive reaction and 30.2% at least 2 positive reactions. The highest age distribution was the 5th decade in females. The face, with the exception of the eyelids, ears, and lips, was the most frequently affected site (comprising 50.3%). The highest sensitization rates were found with nickel (29.1%), thiomersal (10.9%), and cobalt dichloride (9.7%). The lowest positivity included caine mix (0.7%), mercaptobenzothiazole (1.2%), and quinolone mix (1.2%). Metal allergens displayed higher positive rates than any other standard allergens. The overall prevalence was similar with a recent report in Korea. Conclusion: There was no significant difference in the overall prevalence of the most sensitized allergen compared with the reports about previously used Korean standard series.
Bolting Resistant and High-Yielding Angelica acutiloba Cultivar, "Jinil"
Dong Hwi Kim,Hong Seob Yu,Hee Woon Park,Chun Geun Park,Jung Sook Sung,Chung Heon Park,Nak Sul Seong,Geum Soog Kim,Oh Heun Kwon,Cheon Gyoo Park,Young Min Jin 한국육종학회 2006 한국육종학회지 Vol.38 No.3
Angelica acutiloba cultivar developed by a medicinal crop breeding teamof the National Institute of Crop Science during the period from 1993 to 204. The cultivar was selected from Jinbu local variety.Jinil has a green stem color. It has a broader leaf bla
만성 폐 질환 환자에서 조직으로의 산소 전도와 2.3 - DPG 동 정맥간 산소 분압 차에 대한 연구
이동수(Dong Soo Lee),김민수(Min Soo Kim),유근배(Geun Bai Yu),조한래(Han Rae Cho),한설혜(Sul Hai Han),오경식(Kung Sik Oh),임양희(Yang Hee Lim),김주형(Ju Hyung Kim) 대한내과학회 1997 대한내과학회지 Vol.52 No.4
Objectives: The presence of chronic low oxygen delivery to the tissues (blood flow×Hb concentration×arterovenous oxygen content difference) in patients with chronic lung disease (CLD) leads to a aggravated dyspnea. Therefore, total oxygen delivery to the tissues is a reverse correlation with severity of dyspnea. So far, the treatment of patients with CLD has been limited to only the increase of ventilation and perfusion capacity. However, this study focused on the capacity of oxygen delivery to the tissues in patients with CLD. We measured blood oxygen parameters as one of the extended approaches. Method: Simultaneous arterial and venous blood samples from 15 patients with CLD at rest were evaluated for 2.3-DPG, CO-Hb (Carboxy-monohe-moglobin), Met-Hb (methomoglobin), ABGA (Arterial blood gas analysis), VBGA (Venous blood gas analysis) and Hb (Hemoglobin). Smokers and patients with other disease were excluded from the study in order to avoid the factors (2.3-DPG, CO-Hb etc.) which can shift the oxygen dissociation curve. There were 12 men and 3 women, ranging in age from 40 to 75 years. The disease onset varied from 3 years to more than 30 years. Results: 1) As total oxygen delivery to the tissues decreased, Ao2(Arterial oxygen partial pressure) and A-VCb (Arteriovenous oxygen content difference) decreased, while 2.3-DPG increased. Total oxygen delivary to the tissues showed a significant correlation with more A-V and 2.3-DPG than AO2. 2) AO2 had a correlation with A-VO2 but AO2 did not clearly reflect A-VO2. 3) 2.3-DPG activity depended on more A-VO2 than AO2. 4) As A-VO2 decreased, there was more significant relationship among 2.3-DPG, A-VO2 and tissue oxygen delivery. 5) A-VO2 showed a significant reverse correlation with 2.3-DPG as well as Met-Hb % + CO-Hb %. 6) ACO2 (arterial carbon dioxide partial pressure) showed a correlation with 2.3-DPG as well as A-VO2. 7) Arterial PH did not correlate with 2.3-DPG as well as A-V. Conclusion: 1) AO2 in patient with CLD correlated with A-VO2 but AO2 did not clearly reflect A-V. 2) Total oxygen delivery (severity of dyspnea) showed a significant correlation with more A-VO2 and 2.3-DPG than AO2. 3) 2.3-DPG activity depended on more A-VO2 than AO2. 4) 2.3-DPG activity had a reverse correlation with A-V in spite that 2.3-DPG shifts the oxygen dissociation curve to the right, because 2.3-DPG shift is secondary change associated with the low oxygen delivery to the tissues, More extensive k prospective investigations are needed to clearly define correlation among A-VO2, 2.3-DPG and prognosis of patients with CLD.
사회적 약자 케어를 위한 스마트 센서 기반 전동휠체어 기능 개선 연구
최근창(Choi Geun-Chang),조영빈(Cho Young-Bin),이동수(Lee Dong-Su),Akm Ashiquzzaman,김진술(Kim Jin-Sul) 한국정보기술학회 2018 Proceedings of KIIT Conference Vol.2018 No.11
본 논문에서는 1인용 스마트 전동휠체어의 보다 안전한 주행을 위한 지능형 통합 제어보드의 기능 개선 솔루션을 제안한다. 기존 국내 · 외의 전동휠체어 제품의 경우 안전 관련 기능 또는 장치가 포함되지 않은 경우가 많기 때문에 노약자 및 장애인이 지속적으로 증가하는 추세를 보이는 현 상황에서 전동휠체어가 관련된 사고의 발생 빈도 또한 지속적인 증가추이를 보이고 있다. 하지만 현재 상용되는 제품들에는 중고가형 이상의 전동휠체어에만 기본적인 완충작용 장치가 설치되어 있는 한계로 저가형의 제품에도 안전관련 기능이 필요한 실정이다. 따라서, 스마트 제어 플랫폼의 개발을 통해 전동휠체어 이동 중 사용자가 감지하지 못하는 장애물 또는 지형변화를 자동으로 감지 및 전동휠체어의 모터를 자동으로 제어함으로써 사용자가 안정적인 주행을 할 수 있도록 다양한 전동휠체어에 적용 가능한 스마트 전동휠체어 통합제어보드를 제시한다.