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RISS 인기검색어
- 검색키워드
- 저자 : ( Firoz Anwar ) (검색결과 4 건)
- 무료
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Firoz Anwar,Rajbala Singh,Gohar Mushtaq,Abdul Rehman Al-Maliki,Abdullah Sabih,F. A. Al-Abbasi,Aftab Ahmad,Muhammad Afzal,Imran Kazm,Ruqaiyah Kha 대한독성 유전단백체 학회 2015 Molecular & cellular toxicology Vol.11 No.3
Hepatocellular carcinoma (HCC) is the fifth and third most common cause of cancer-related deaths. Erythrosine, a commonly used coloring agent in tablet preparation was studied for its role when supplemented with sub necrotic dose of DENA (n-diethyl nitrosamine) to induced HCC in Wistar rats. Single dose of chemical carcinogen DENA with intraperitoneal injection (20 mg/kg) administered before Erythrosine at a dose 0.014 mg/kg by p.o, DENA treated rats and alone. Exposure of DENA and Erythrosine alters the levels of Serum glutamate oxaloacetate transaminase (SGO T), Serum glutamate pyrophosphate transaminase (SGPT), Alkaline phosphate (ALP), Total Bilirubin (TBR), Blood uric acid, urea, lipid profile and Serum alpha-feto protein (AFP) in Wistar rats, with further alteration in intracellular antioxidant enzyme profile Lipid Per oxidation (LPO), Glutathione Peroxidase (GPx), Melanoaldehyde (MDA), Glutathione Reductase (GR), Catalase (CAT), Glutathione (GSH), Glutathione- S-Transferase (GST), Superoxide Dismutase (SOD) along with Vit. C and Vit. E conc.. Moreover Histopathological examinations of the liver tissue showed marked effect of DENA and Erythrosine exposure on liver structure. The results concluded that Erythrosine used as coloring agent for tablet coating as well as food colorant in India, was found to be an inducer as liver proliferating agent and promoter of HCC.
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( Vikas Kumar ),( Firoz Anwar ) 대한결핵 및 호흡기학회 2020 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.128 No.-
Purpose Phosphoinositide 3- kinase (PI3K)-AKT-mammalian target of rapamycin (mTOR) pathways is considered as the singling pathway which activates the diverse cellular function viz., survival, cell expansion, vesicular transport and proliferation and found frequently dysregulated pathway in lung cancer. Consequently, flavonoids-based inhibitors play a key kinase role in the pathway including mTOR, PI3K and AKT, have been extensively scrutinized in targeting the oncology in recent years. The common pathway to PI3K-Akt-mTOR used to target during the lung cancer therapy. Therefore, the current study was aimed to peruse the resveratrol as dual PI3K/mTOR for lung cancer. Method In the current experimental study mice were randomly divided into different groups. The oxidative stress was evaluated in term of antioxidant parameters, interleukin (IL)-1β,tumor necrosis factor-α (TNF-α) and interleukin (IL)-6 were measured via using the standard enzyme-linked immunosorbent assay kits. The concentration of PI3K, P-PI3K, mTOR,P-mTORAkt and P-Akt were determined via using the Western blot techniques. We also performed the histopathological study to identify the changes during the disease. Result Resveratrol significantly suppressed the oxidative stress via improving the status of endogenous antioxidant parameters such as SOD (43.4%), CAT (48.5%), GSH (52.4%) and MPO (47.6%); proinflammatory cytokines including TNF-α (49.5%), IL-6 (43.4%), IL-1β (53.4%) in a dose dependent manner. Disease control group mice confirmed the change in protein levels of PI3K/Akt/ mTOR pathway in lung as compared to normal control, which were significantly down-regulated by the Resveratrol in a dose dependent manner. In the histological study, we observed that the Resveratrol substantially reduced the benzopyrene induced neutrophils in lung tissue. Conclusion It can be concluded that Resveratrol has shown promising anticancer effect via attenuation of PI3K/Akt/mTOR against lung cancer and signifies the potential therapeutic relevance for further development.
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( Vikas Kumar ),( Firoz Anwar ) 대한결핵 및 호흡기학회 2019 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.127 No.-
Purpose: Phosphoinositide 3- kinase (PI3K)-AKT-mammalian target of rapamycin (mTOR) pathways is considered as the singling pathway which activates the diverse cellular function viz., survival, cell expansion, vesicular transport and proliferation and found frequently dysregulated pathway in lung cancer. Consequently, flavonoids-based inhibitors play a key kinase role in the pathway including mTOR, PI3K and AKT, have been extensively scrutinized in targeting the oncology in recent years. The common pathway to PI3K-Akt-mTOR used to target during the lung cancer therapy. Therefore, the current study was aimed to peruse the resveratrol as dual PI3K/mTOR for lung cancer. Method: In the current experimental study mice were randomly divided into different groups. The oxidative stress was evaluated in term of antioxidant parameters, interleukin (IL)-1β, tumor necrosis factor-α (TNF-α) and interleukin (IL)-6 were measured via using the standard enzyme-linked immunosorbent assay kits. The concentration of PI3K, P-PI3K, mTOR, P-mTOR Akt and P-Akt were determined via using the Western blot techniques. We also performed the histopathological study to identify the changes during the disease. Result: Resveratrol significantly suppressed the oxidative stress via improving the status of endogenous antioxidant parameters such as SOD (43.4%), CAT (48.5%), GSH (52.4%) and MPO (47.6%); proinflammatory cytokines including TNF-α (49.5%), IL-6 (43.4%), IL-1 β (53.4%) in a dose dependent manner. Disease control group mice confirmed the change in protein levels of PI3K/Akt/mTOR pathway in lung as compared to normal control, which were significantly down-regulated by the Resveratrol in a dose dependent manner. In the histological study, we observed that the Resveratrol substantially reduced the benzopyrene induced neutrophils in lung tissue. Conclusion: It can be concluded that Resveratrol has shown promising anticancer effect via attenuation of PI3K/Akt/mTOR against lung cancer and signifies the potential therapeutic relevance for further development.
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