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흰쥐 腦의 中心扁桃核에서의 Substance P 및 Enkephalin 함유구조의 형태학적 특징
마도훈,조희중,김은희,박매자,배용철,홍해숙,주강 慶北大學校 醫科大學 1990 慶北醫大誌 Vol.31 No.4
흰쥐 뇌의 중심편도핵에서의 substance P (SP) 및 Enkephalin (ENK) 함유신경세포 및 축삭종말의 분포를 관찰하기 위하여 peroxidase antiperoxidase법을 행하여 다음의 결과를 얻을 수 있었다. SP함유신경세포는 중심편도핵의 medial zone에 분포하였고 SP함유축삭종말은 lateral capsular zone에서 고밀도로 관찰되었다. SP함유신경세포는 원형 내지는 타원형이었고 2∼3개의 근위수상돌기(proximal dendrite)를 가졌다. ENK함유신경세포 및 축삭종말은 공히 central 및 lateral capsular zone에 존재하였다. ENK함유 신경세포는 직경이 약 17-24㎛ 정도였고 3∼4개의 근위수상돌기를 관찰할 수 있었다. The central amygdaloid nucleus is rich in a number of neuropoptides. The present study examines the distribution and morphological characteristics of substance P (SP) and leucine-enkephalin (ENK) containing neurons in this nucleus. The results obtained were as follows: SP immunoreactive cells were observed within the medial zone and SP immunoreactive axon terminals were heaviest within the lateral capsular zone. The immunoreactive cells were round or oval shape (diameter, 15-20㎛) and had two or three proximal dendrites. ENK immunoreactive cells and axon terminals located within central and capsular zones. The immunoreactive cells were round or oval shape (diameter, 17-24㎛) and had three or four proximal dendrites.
1,2-Di-O-benzyl-6, 7-O-isopropylidene-1,2,6,7-tetrahydroxy-hept-3-ene의 합성(Ⅰ)
마은숙 대구효성가톨릭대학교 응용과학연구소 1994 응용과학연구논문집 Vol.3 No.-
1,2-Di-O-benzyl-6,7-O-isopropylidene-1,2,6,7-tetrahydroxy-hept-3-ene(10) was prepared as intermediate of β-hydroxy-δ-lactone moiety in compactin. Compactin is not only potent inhibitor of enzyme HMG-CoA reductase(HMGR), the rate-limiting enzyme in cholesterol biosynthesis, but also effective hypocholestereolemic agents in man. 3,4-O-Isopropylidene-3,4-dihydroxybut-1-yl triphenyl phosphonium iodide(4) was synthesized in four steps from (s)-(-)-1, 2, 4-butantriol and 3,4-Di-O-benzyl-glyceraldehyde(9) was prepared in five steps from commercially available, inexpensive d-mannitol. By the Wittig reaction, compound(10) was synthesized with comp.(4), comp(9) and n-Buli in -78℃. Cis isomer was obtained 4:1 ratio and observed 6:1 ratio in using of HMPA.
6,7-O-Dibenzyl-1,2-O-Isopropylidene 1,2,6,7-Tetrahydroxy-Hept-3-ene의 합성(Ⅱ)
강혜경,마은숙 대구효성가톨릭대학교 응용과학연구소 1995 응용과학연구논문집 Vol.4 No.-
Compactin, isolated from Penicillium brevicompactum by Brown and from P. citrinum by Endo, has hypocholesterolemic activity. The key structure of its activity was known β-hydroxy δ-lacone portion. In our ex-periments, 6, 7-O-dibenzyl-1, 2-O-isopropylidene-1, 2, 6, 7-tetrahydroxy-hept-3-ene(Ⅷ) was synthesized as intermediate for synthesis of β-hdyroxy δ-lacone por-tion. 4-Hydroxymethyl-2-penyl-1, 3-dioxane(Ⅰ) was prepared by the reaction of (S)-(-)-1, 2, 4-butantriol and benzaldehyde dimethylacetal and 4-(O-benzylmethyl)-2-phenyl-1, 3-dioxane(Ⅱ)was obtained by reductive cleavage of compound(Ⅱ)with LiAlH_4 and AlCl_3 anhydrous. 1, 2-O-dibenzyl-1, 2-dihydroxybutyl bromide(Ⅳ) was prepared from compound(Ⅲ_a) by bromination with N-bromosuccinimide(NBS) and the reaction of compound(Ⅳ) and triphenylphosphine produced 1, 2-O-dibenzyl-1, 2-dihydroxybutyl tri-phenylphosphonium bromide(Ⅴ). On the other hand, the reaction with d-mannitol and 2, 2-dimethoxypropane produced 1,2: 5,6-bis-O-isopropylidene-d-mannitol(Ⅵ), and (s)-1, 2-isopropylidene glyceral-dehyde(Ⅶ) was synthesized by the reaction of lead tetraacetate and compound(Ⅵ). The Wittig reaction with phosphonium salt(Ⅴ), glyceraldehyde(Ⅶ) and n-butyllithium pro-duced compound(Ⅷ). The structures of these compounds were identified by means of ^1H-NMR, ^13NMR and IR spectra.
마은숙(Eun Sook Ma) 대한약학회 2002 약학회지 Vol.46 No.6
Dilithiation of 4-(pivaloylamino)pyridine (5) followed by reaction with tetraisopropylthiuram disulfide(TITD) gave rise to 3-(diisopropyldithiocarbamato) 4- pivaloylamino)pyridine (6). 3-Mercapto- 4H-pyrrolopyridine(2) was synthesized from compound 6 by two methods. The first method was that compound 6 was treated with 5M-HCI to form 2-t-butykhiazolo [5,4-c]pyridine (7) and hydrolysed in refluxing 10% NaOH and solid NaOH to prepare bis(4-amino-3-pyridyl)disulfide (8). And compound 8 was reacted with 2,5-dimethoxyteytetrahydrofuran and NaBH4 to afford compound 2. The second method was that compound 6 was hydrolysed with 10% NaOH and followed to react with 2,5-dimethox-ytetrahydmfuran to form compound 11. And then compound 11 was treated with 20% ethanolic KOH solution to synthesize compound 2.
환상 α,β-불포화 카르보닐 화합물의 선택적 에폭시화 및 환원
마은숙(Eun Sook Ma) 대한약학회 2005 약학회지 Vol.49 No.6
Diosgenin (25(R)-spirost-5-en-3 β-ol) was oxidized with 2,3-dichloro-5,6-dicyano-1,4-benzoquinone to form 25(R)-1,4,6-spirostatrien-3-one (1) as rigid cyclic α,β-unsaturated carbonyl compound. This compound was reacted with H2O2, m-chloroperoxybenzoic acid (mCPBA), NaOCl in the presence with (R,R)- or (S,S)-Jacobsen catalyst, tert-butyl-hydroperoxide (TBHP) in Mo(CO)6, and in VO(acac)2 catalyst, respectively. 25(R)-1,4,6-spirostatrien-3-one (1) was reduced with NaBH4, L-Selectride, LiAIH4, BH3(CH3)2S, Superhydride, Red-Al, and lithium tri-tert-butoxyaluminium hydride. And 25(R)-4,6-spirostadien-3β-ol (4) was treated with H2O2, mCPBA, TBHP in D-(-)- and L-(+)-diisopropyltar-trate and Ti(O-iPr)4 condition (Sharpless asymmetric epoxidation), TBHP in Mo(CO)6 and in VO(acac)2 catalyst, respectively.
마은숙(Eun Sook Ma) 대한약학회 2001 약학회지 Vol.45 No.6
(S)-5-lodo-2-aminoindan HCI (7) was synthesized for developing a serotonergic agent. (S)-Phenylalanine was protected with trifluoroacetyl group and compound 2 was prepared by direct iodination in acetic acid and in the presence of I2, KIO4, and sulfuric acid. Compound 3 was cyclized by Friedel-Crafts reaction and reduced with NaBH4 to form 5-iodo-2-(N- trifluroacetyl) aminoindan-1-ol (4) . This compound was reduced to indan derivative 5 using the triethylsilane and BF3 · Et2O. It was basified with K2CO3 solution and treated with saturated HCI in ethyl ether to isolate compound 7.
마은숙 대구효성가톨릭대학교 응용과학연구소 1991 응용과학연구논문집 Vol.1 No.-
5-Chloro-and 5-hydroxyantranilic acid were esterified with methanol and ethanol in the presence of c-H_2SO_4. 5-Hydroxyanthranilates were reacted with p-toluenesul-fonyl chloride in triethylamine to give 5-p-toluenesulfonyoxyanthrani -late derivatives. According to Schotten-Baumann method, these compounds were reacted with phenoxyacetyl chloride and dl-2-phenoxypropionyl chloride to afford correspoding amide derivatives. And then N-substituted-5-p-tosyloxyanthranilates were reacted with NaI in dry acetone. N-phenoxyacethyl-5-iodoanthranilic acid ethyl ester was synthesized but three compounds were not reacted with NaI. The struture of synthesized compounds was identified with IR and NMR spectra.