Effects of Lycopene Alone or Combined with Melatonin on Methotrexate-Induced Nephrotoxicity in Rats

Oguz, Elif,Kocarslan, Sezen,Tabur, Suzan,Sezen, Hatice,Yilmaz, Zehra,Aksoy, Nurten Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.14

Methotrexate (Mtx), used for its anticancer and immunsuppresive properties, is known to be a nephrotoxic agent. We aimed to investigate the effects of lycopene (Lyc) alone or combined with melatonin (Mel) on Mtxinduced nephrotoxicity since both of these agents have antioxidant and anti-inflammatory effects. Nephrotoxicity was induced by intraperitoneal administration of methotrexate at a dose of 20 mg/kg. Treatment both with Lyc alone and Lyc combined with Mel provided significant reduction in tumor necrosis factor-alpha, interleukin 1-beta and ceruloplasmin levels in Mtx administered rats. Hovewer, Lyc combined with Mel provided a significant reduction also in NO levels. Hstopathological examination showed that there was an obvious improvement in the degenerative changes compared to Mtx administrated group with the Lyc combined Mel group giving best protection. In conclusion Lyc alone and combined with Mel provided significant improvement against renal damage caused by Mtx, preseumably via antioxidant and anti-inflammatory activities.

Landfilling of Domestic Waste Water Treatment Plant Sludges, Istanbul Case Study

( Şenol Yildiz ),( Elif Yilmaz ),( M. Sinan Bilgili ) 한국폐기물자원순환학회 2010 APLAS Vol.2010 No.0

A novel poly(glycine methacrylate-co-3-thienylmethyl methacrylate)- polypyrrole-carbon nanotube-horseradish peroxidase composite film electrode for the detection of phenolic compounds

Seyda Korkut Ozoner,Faruk Yilmaz,Asuman Celik,Bulent Keskinler,Elif Erhan 한국물리학회 2011 Current Applied Physics Vol.11 No.3

A novel amperometric biosensor, based on poly(glycine methacrylate-co-3-thienylmethyl methacrylate)-polypyrrole-carbon nanotube {Poly(GMA-co-MTM)/PPy/CNT} composite matrix, was used for the determination of eighteen phenol derivatives. The enzyme, horseradish peroxidase (HRP) was covalently immobilized to this novel composite polymer matrix. The measurement of the phenolic compounds was carried out by the electrode reduction of the generated phenoxy radical, product of the enzymatic reaction, at a fixed voltage of ―50 mV. Optimization of the experimental parameters was performed with regard to pH, operational potential and hydrogen peroxide concentration. The differences in sensitivity,linear range, detection limit and response time observed for series of phenolic compounds were discussed. The biosensor gave no response to m-cresol, o-cresol and p-cresol. Poly(GMA-co-MTM)/PPy/CNT/HRP composite film electrode retained 80% of its initial activity after the usage of 700 measurements in one month.

Evaluation and Management of Antrochoanal Polyps

Huseyin Yaman, MD,Suleyman Yilmaz, MD,Elif Karali, MD,Ender Guclu, MD,Ozcan Ozturk, MD 대한이비인후과학회 2010 Clinical and Experimental Otorhinolaryngology Vol.3 No.2

Antrochoanal polyps (ACPs) are benign polypoid lesions arising from the maxillary antrum and they extend into the choana. They occur more commonly in children and young adults, and they are almost always unilateral. The etiopathogenesis of ACPs is not clear. Nasal obstruction and nasal drainage are the most common presenting symptoms. The differential diagnosis should include the causes of unilateral nasal obstruction. Nasal endoscopy and computed tomography scans are the main diagnostic techniques, and the treatment of ACPs is always surgical. Functional endoscopic sinus surgery (FESS) and powered instrumentation during FESS for complete removal of ACPs are extremely safe and effective procedures. Physicians should focus on detecting the exact origin and extent of the polyp to prevent recurrence.

The glass-ceramic sealant materials obtained from basalt for SOFC

Ediz Ercenk,A. Elif Cicekli,Senol Yilmaz 한양대학교 세라믹연구소 2016 Journal of Ceramic Processing Research Vol.17 No.12

In the current study, utilization possibilities of the basalt based glass-ceramic as a sealant material for solid oxide fuel cell(SOFC) were investigated. Crushed, milled and sieved basalt powders were modified by some additives. The basalt powderand modified mixture were separately melted in alumina crucible and cast into water to obtain glass granules. These granuleswere milled, and exposed to heating microscopy and differential thermal analysis (DTA). Some parameters such as glasstransition and softening temperature were determined by these analyses. The powders were applied on the Crofer 22 APUinterconnector material, and heat treatment was carried out. The interface characteristics between the glass-ceramic layer andinterconnector were characterized using X-ray diffraction analysis (XRD) and scanning electron microscopy (SEM). Theresults showed that the basalt base glass-ceramic sealant material exhibited promising properties to use for SOFC.

Reliability of chest pain risk scores in cancer patients with suspected acute coronary syndrome

Cansu Alyeşil,Serkan Yilmaz,İbrahim Ulaş Özturan,Murat Pekdemir,Elif Yaka,Nurettin Özgür Doğan 대한응급의학회 2020 Clinical and Experimental Emergency Medicine Vol.7 No.4

Objective The history, electrocardiogram, age, risk factors, troponin (HEART), the thrombolysis in myocardial infarction (TIMI), and Global Registry of Acute Coronary Events (GRACE) scores are useful risk stratification tools in the emergency department (ED). However, the accuracy of these scores in the cancer population is not well known. This study aimed to compare the performance of cardiac risk stratification scores in cancer patients with suspected acute coronary syndrome (ACS) in the ED. Methods This prospective cohort study recruited patients with cancer who visited the ED because of suspected ACS. The development of any major adverse cardiac events (MACE) within 6 weeks was recorded, with the study outcome being a MACE within 6 weeks of ED admission. Results A total of 178 patients participated in this study, of whom 5.6% developed a MACE. Statistically significant differences were found between the mean HEART and TIMI scores in predicting MACE. The HEART score had the highest area under the curve (0.64; 95% confidence interval, 0.48–0.81), highest sensitivity (80%), and highest negative predictive value (97.5) in patients with cancer. Conclusion We found a similar rate of MACE in cancer patients with low-risk chest pain compared to that in the general population. However, the HEART, TIMI, and GRACE scores had a lower performance in cancer patients with MACE compared to that in the general population.

Experimental investigation on mechanical properties of Multi Wall Carbon Nanotubes (MWCNT) reinforced aluminium metal matrix composites

İsmail Topcu,Muhammet Ceylan,Elif Burcu Yilmaz 한양대학교 세라믹연구소 2020 Journal of Ceramic Processing Research Vol.21 No.5

The aim of this research is to obtain better micrographs and to perform the mechanical characterization of Multi Wall CarbonNanotubes (MWCNT) consolidated aluminum matrix composite (AMC). This research is focused on the mechanical behaviorand microstructure characteristics in MWCNT consolidated aluminum matrix composites. The composites of MWCNT/Alwere successfully fabricated using powder metallurgy (PM) mechanical alloying (MA) sintering. X-ray diffraction (XRD) andScanning electron microscopy (SEM) micrographs were utilized in order to determine the porosity, density and hardnesscharacteristics to observe if they are affected or not concerning the performance of composites in different reinforced %MWCNT rate conditions. Along with SEM and XRD studies, this study details the homogeneous distribution of nanotubeswhich showed no evidence of decomposition; this was supported by a successive increase in hardness and abrasion resistance. This increase in abrasion resistance and hardness can be accredited to the further activation of the slip system due to thepresence of MWCNTs. Based on the conclusions of this study, the authors determined that the mechanical alloying sinteringmethod provides promising results for the mechanical alloying fabrication of MWCNT/Al composites, especially due to thedifferent % rate reinforced up capabilities.

Use of noninvasive volume assessment methods to predict acute blood loss in spontaneously breathing volunteers

Asim Tomo,Murat Pekdemir,Ibrahim Ulas Ozturan,Nurettin Ozgur Dogan,Elif Yaka,Serkan Yilmaz 대한응급의학회 2021 Clinical and Experimental Emergency Medicine Vol.8 No.1

Objective The use of noninvasive volume assessment methods to predict acute blood loss in spontaneously breathing patients remains unclear. We aimed to investigate changes in the pleth variability index (PVI), vena cava collapsibility index (VCCI), end-tidal carbon dioxide (EtCO2), pulse pressure (PP), and mean arterial pressure (MAP) in spontaneously breathing volunteers after acute loss of 450 mL blood and passive leg raise (PLR). Methods This prospective observational study enrolled healthy volunteers in the blood donation center of an academic hospital. We measured the PVI, EtCO2, VCCI, MAP, and PP before blood donation; at the 0th and 10th minute of blood donation; and after PLR. The primary outcome was the changes in PVI, EtCO2, VCCI, MAP, and PP. Results We enrolled thirty volunteers. There were significant differences among the four obtained measurements of the PVI, EtCO2, and MAP (P<0.001, P<0.001, P<0.001, respectively). Compared to the predonation values, post-hoc analysis revealed an increase in the PVI at the 0th min postdonation (mean difference [MD], 5.4±5.9; 95% confidence interval [CI], -7.6 to -3.1; P<0.001); a decrease in the EtCO2 and MAP at the 0th and 10th minute postdonation, respectively (MD, 2.4±4.6; 95% CI, 0.019 to 4.84; P=0.008 and MD, 6.4±6.4; 95% CI, 3 to 9.7; P<0.001, respectively). Compared with EtCO2 at the 10th minute, the value increased after PLR (MD, 1.8±3.2; 95% CI, 0.074 to 4.44; P=0.006). Conclusion The PVI and EtCO2 could detect early hemodynamic changes after acute blood loss. However, it remains unclear whether they can determine volume status in spontaneously breathing patients.