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Lim, Myong Cheol,Yoo, Heong Jong,Song, Yong Jung,Seo, Sang-Soo,Kang, Sokbom,Kim, Sun Ho,Yoo, Chong Woo,Park, Sang-Yoon Asian Society of Gynecologic Oncology; Korean Soci 2017 Journal of Gynecologic Oncology Vol.28 No.4
<P><B>Objective</B></P><P>To investigate the survival outcomes in patients with bulky stage IIIC and IV ovarian cancer, treated by primary debulking surgery (PDS) and selective use of neoadjuvant chemotherapy (NAC) according to institutional criteria.</P><P><B>Methods</B></P><P>Medical records for advanced ovarian cancer patients who were treated at National Cancer Center (NCC) between December 2000 and March 2009 were retrospectively reviewed in the comprehensive cancer center. Bulky stage IIIC and IV ovarian cancer cases were included. Current NCC indication for NAC is determined based on patients' performance status and/or computerized tomography (CT) findings indicating difficult cytoreduction. After NAC, all traces of regressed metastatic ovarian cancer, potentially including chemotherapy-resistant cancer cells, were surgically removed.</P><P><B>Results</B></P><P>Of the 279 patients with bulky stage IIIC and IV, 143 (51%) underwent PDS and 136 (49%) received NAC. No gross residual and residual tumor measuring ≤1 cm was achieved in 66% and 96% of the PDS group and 79% and 96% of the NAC group, respectively. The median progression-free survival (PFS) and overall survival (OS) time were 20 months and not reached, but might be estimated more than 70 months in the PDS group and 15 and 70 months in the NAC group, respectively.</P><P><B>Conclusion</B></P><P>Extensive cytoreductive surgery to minimize residual tumor and selective use of NAC based on the institutional criteria could result in improved survival outcomes. Until further studies can be done to define the selection criteria for NAC after surgery, institutional criteria for NAC should consider the ability of the surgeon and institutional capacity.</P>
曺南仲,裵明,朴世鍾,姜亨求,尹鍾晩 대한감염학회 1982 감염 Vol.14 No.1
Clinical analysis of widal test was done on 105 cases of typhoid fever, 55 cases of paratyphoid fever and 50 cases of non-typhoid fever treated at Chonnom National University from January 1978 to June 1981. The following results were obtained. 1) of 435 patients suspected as typhoid fever clinically, who received both blood and stool culture, 105 cases of typhoid fever and 55 cases of paratyphoid fever(52 cases: paratyphoid A, 3 cases: paratyphoid B) were4 confirmed bacteriogically. 2) Of 105 cases of confirmed typhoid fever, organism was isolated by blood culture in 82 cases(78%) and stool culture in 25 cases(24%) in which 2 cases are confirmed both culture. 3) Widal test as a O titer was significantly positive in 42 cases, in which 22 cases(53%) during first week of illness, 13 cases(31%) during second week, 6 cases(14%) during third week and 1 cases(2%) during the forth week. 4) Of the 105 patients studied, 61 cases(58%) had an significant abnormal H and/or O titer (over 1:160), in which 42 cases (40%) had abnormal O titer, 50 cases (48%) abnormal H titer, 11 cases (10%) abnormal O titer only and 19 cases (18%) abnormal H titer only. In 44 cases (42%) widal test was normal.
CHUNG, Hwan-Suck,KANG, Moonkyu,CHO, Chongwoon,PARVEZ, Shoukat,PARK, Chong-heong,KIM, Dongwoo,OH, Joonghwan,KIM, Hongyeoul,SHIN, Minkyu,HONG, Moochang,KIM, Yangseok,BAE, Hyunsu WHO COLLABORATING CENTRE FOR TRADITIONAL MEDICINE 2007 東西醫學硏究所 論文集 Vol.2007 No.-
Moutan cortex (MC) is one of the most widely used Oriental herbal medicines for treating inflammatory diseases. In this study, the efTect of MC on lipopolysaccharide (LPS) and rccombinant interferon-gamma(rIF)-indiiced productioii ofnitric oxide (NO) and tumor necrosis factor (TNFγ)-aIpha were examined using mouse perituneal macrophages. MC inhibited the LPS/rIFN-γ-induced expression of inducible nitric oxide synthase (iNOS) and TNF-alpha release. To clarify the mechanism involved, the effect of MC on the activation of nuclear factor (NF)-kappaB was examined. The LPS/rIFN-γ-induced activation of NF-kappaB was almost completely blocked by MC at 0.5 mg/ml. These findings demonstrate that the inhibition of the LPS/rlFN-γ-induced production of NO and TNF-atpha by MC is due to the inhibition of NF-kappaB activation.