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Short Report : Acromegaloid Facial Appearance Syndrome with Generalized Hypertrichosis Terminalis
방찬일 ( Chan Yl Bang ),한성협 ( Sung Hyub Han ),변지원 ( Ji Won Byun ),양보희 ( Bo Hee Yang ),송희진 ( Hee Jin Song ),인승균 ( Seung Gyun In ),신정현 ( Jeong Hyun Shin ),최광성 ( Gwang Seong Choi ) 대한피부과학회 2011 大韓皮膚科學會誌 Vol.49 No.2
Acromegaloid facial appearance (AFA) syndrome is a rare autosomal dominant disease, consisting of an acromegaloid face, a bulbous nose, and narrowing of the palpaebral fissure. In 1996, Irvin first reported a case of a combination of acromegaloid facial appearance syndrome and congenital hypertrichosis, and reported this case as a new disease of acromegaloid facial appearance with generalized hypertrichosis terminalis, which is differentiated from both AFA syndrome and congenital hypertrichosis/gingival hyperplasia. We report herein the first Korean case of acromegaloid facial appearance with generalized hypertrichosis terminalis. (Korean J Dermatol 2011; 49(2):184~187)
방찬일 ( Chan Yl Bang ),변지원 ( Ji Won Byun ),신정현 ( Jeong Hyun Shin ),황승식 ( Seung Sik Hwang ),최광성 ( Gwang Seong Choi ) 대한피부과학회 2013 대한피부과학회지 Vol.51 No.12
Background: Female pattern hair loss (FPHL) is the most common type of pattern hair loss in women. It has been suggested that FPHL is associated with several serological abnormalities. Objective: The aim of this study is to investigate the clinical characteristics and serological abnormalities of the Korean FPHL patients and to compare them with the data from the Korea National Health and Nutrition Examination Survey V and other relative reports. Methods: We retrospectively evaluated the age, duration and comorbidities in 264 Korean patients who have been diagnosed with FPHL. Serum levels of serum iron, total iron binding capacity, ferritin, hemoglobin, free thyroxine (T4), thyroid stimulating hormone, testosterone and 25-(OH) vitamin D were being investigated. Results: FPHL was most commonly found in patients aged from 20 to 29 years old and 55% of the patients visited the hospital one year after the onset of FPHL. In FPHL patients, the levels of testosterone, hemoglobin, serum ferritin, 25-(OH) vitamin D, thyroid stimulating hormone were all significantly higher than the average Korean adult women. And, the free thyroxine level was significantly lower than the average Korean adult women. When analyzed according to the menopausal status, premenopausal FPHL patients showed significantly higher serum levels of hemoglobin, ferritin, and 25-(OH) vitamin D than those of the Korean adult women. But, the postmenopausal FPHL patients showed significantly higher serum levels of 25-(OH) vitamin D than those of Korean adult women. Conclusion: The levels of ferritin, testosterone and vitamin D of FPHL patients were elevated higher than those of the Korean adult women. To confirm these results in the future, further large scaled evaluation is suggested.
방찬일 ( Chan Yl Bang ),변지원 ( Ji Won Byun ),양보희 ( Bo Hee Yang ),신정현 ( Jeong Hyun Shin ),최광성 ( Gwang Seong Choi ),송희진 ( Hee Jin Song ) 대한피부과학회 2011 대한피부과학회지 Vol.49 No.4
Circumscribed palmar or plantar hypokeratosis is a rare dermatosis, and it consists of asymptomatic erythematous, well-circumscribed and depressed patch with scaly borders on the palm or sole. It usually affects middle-aged or elderly women. Histopathologically, it has a sharp stair between the normal and involved skin, and a demarcated area with an abrupt decrease in the horny layer thickness. We report herein a case of circumscribed palmar hypokeratosis that was successfully treated with cryotherapy. (Korean J Dermatol 2011;49(4):345∼347)
Case Reports : A Case of Cicatricial Alopecia Associated with Erlotinib
( Bo Hee Yang ),( Chan Yl Bang ),( Ji Won Byun ),( Sung Hyub Han ),( Hee Jin Song ),( Seung Gyun In ),( Jeong Hyun Shin ),( Gwang Seong Choi ) 대한피부과학회 2011 Annals of Dermatology Vol.23 No.3s
Erlotinib is a small-molecule tyrosine kinase inhibitor (TKI) of the epidermal growth factor receptor (EGFR). Erlotinib has been used primarily to treat non-small cell lung cancer. In addition to its role in tumor cells, EGFR is also an important regulator of growth and differentiation in the skin and hair. Therefore, EGFR-TKIs have been associated with a number of cutaneous side effects including follicular acneiform eruptions, cutaneous xerosis, chronic paronychia, desquamation, seborrheic dermatitis, and hair texture changes. Herein, we report a rare case of a 61-year-old woman who was treated with erlotinib and experienced cicatricial alopecia. (Ann Dermatol 23(S3) S350~S353, 2011)
A Case of Cicatricial Alopecia Associated with Erlotinib
Yang, Bo Hee,Bang, Chan Yl,Byun, Ji Won,Han, Sung Hyub,Song, Hee Jin,In, Seung Gyun,Shin, Jeong Hyun,Choi, Gwang Seong Korean Dermatological Association; The Korean Soci 2011 Annals of Dermatology Vol.23 No.suppl3
<P>Erlotinib is a small-molecule tyrosine kinase inhibitor (TKI) of the epidermal growth factor receptor (EGFR). Erlotinib has been used primarily to treat non-small cell lung cancer. In addition to its role in tumor cells, EGFR is also an important regulator of growth and differentiation in the skin and hair. Therefore, EGFR-TKIs have been associated with a number of cutaneous side effects including follicular acneiform eruptions, cutaneous xerosis, chronic paronychia, desquamation, seborrheic dermatitis, and hair texture changes. Herein, we report a rare case of a 61-year-old woman who was treated with erlotinib and experienced cicatricial alopecia.</P>
양보희 ( Bo Hee Yang ),방찬일 ( Chan Yl Bang ),변지원 ( Ji Won Byun ),한성협 ( Sung Hyub Han ),송희진 ( Hee Jin Song ),인승균 ( Seung Gyun In ),신정현 ( Jeong Hyun Shin ),최광성 ( Gwang Seong Choi ) 대한피부과학회 2011 대한피부과학회지 Vol.49 No.2
Acantholytic squamous cell carcinoma is a well-defined, rare variant of squamous cell carcinoma in which significant portions of the neoplastic tissue show, on microscopy, a pseudoglandular or tubular pattern. It usually presents in aged patients as an erythematous nodule with scales, crust, and ulceration on sun-exposed areas. Herein we report a case of acantholytic squamous cell carcinoma that occurred on the Rt 4th toeweb of a 70-year-old man. (Korean J Dermatol 2011; 49(2):195~197)