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Boron nitride nanotube-CREKA peptide as an effective target system to metastatic breast cancer
Ferreira Tiago Hilário,de Oliveira Freitas Luiza Baptista,Fernandes Renata Salgado,dos Santos Virgílio Mateus,Resende Jarbas Magalhães,Cardoso Valbert Nascimento,de Barros André Luís Branco,de Sousa E 한국약제학회 2020 Journal of Pharmaceutical Investigation Vol.50 No.5
Purpose The development of nanomaterials that are capable of recognizing disease-specific biomarkers with high sensitivity and specificity is related to several advances in the field of nanomedicine. Furthermore, the targeted delivery of anticancer agents to tumor tissues enhances their efficiency and reduces their toxic side effects. Boron nitride nanotubes (BNNTs) are nanostructured materials, analog to carbon nanotubes, which present good biocompatibility and morphology suitable for tumor cell internalization. CREKA is a pentapeptide that has a high affinity to fibrin, a protein found in the new tumor vessels in the early stages of metastasis and in thrombosis regions. Methods In this study BNNTs were chemically functionalized with the peptide CREKA, and this system was characterized by Fourier transform infrared spectroscopy (FTIR), thermogravimetric analysis (TGA), zeta potential, scanning electron microscopy, and transmission electron microscopy. Results After the mentioned chemical steps, the FTIR analysis shows an organic phase related to the CREKA, TGA indicates that about 10% of the peptide is firmly attached to BNNT surface. In addition, the radiolabeling process was successful, achieving the purity required for the biodistribution study. In vivo experiments showed that a considerable amount of BNNTCREKA was accumulated at the tumor and metastasis sites. Conclusion The present results indicate an effective targeting of the system to tumor and metastasis sites. Further studies can reveal potential applications of functionalized BNNTs in cancer treatment.
허용학(Yong-Hak Huh),R.E Edwards,M.W. Brown,E.R. de los Rios 대한기계학회 2002 대한기계학회 춘추학술대회 Vol.2002 No.3
Governing parameters on location of crack Initiation and direction of crack initiation were investigated by performing fretting fatigue tests and analysis on Al 2024-T351. Fatigue tests were carried out using biaxial fatigue machine. It was shown that the dominant fatigue crack tended to initiate at the outer edge of one of the four bridge pads, growing at an angle beneath a pad, before turing perpendicular to the orientation of the axial load. Distribution of stresses generated during fretting fatigue loading along the interface was calculated by elastic FE simulation. It can be known that the location of crack initiation can be predicted by using the maximum tangential stress range or the maximum shear stress range. Futhermore, the crack initiation direction can be predicted by a maximum tangential stress range.
Gate-tunable graphene-organic interface barrier for vertical transistor and logic inverter
Parui, Subir,Ribeiro, Má,rio,Atxabal, Ainhoa,Bairagi, Kaushik,Zuccatti, Elisabetta,Safeer, C. K.,Llopis, Roger,Casanova, Fè,lix,Hueso, Luis E. American Institute of Physics 2018 APPLIED PHYSICS LETTERS Vol.113 No.15
Graziotti, Guillermo H.,Menendez, Jose M. Rodriguez,Rios, Clara M.,Cossu, Maria E.,Bosco, Alexis,Affricano, Nestor O.,Ceschel, Alejandra Paltenghi,Moisa, Sonia,Basso, Lorenzo Asian Australasian Association of Animal Productio 2011 Animal Bioscience Vol.24 No.1
The aim was to determine the relationship between muscle structure and meat quality traits in neuromuscular compartments (NMCs: R1, R2, R3, R4) of pig semitendinosus muscle. Barrows from the INTA-MGC genetic line (Argentina) were slaughtered at 100 kg body weight. In each NMC the following parameters were determined: the fibre types I, IIA, IIX and IIB by immunohistochemistry, the fibre cross sectional area (FCSA), the pH of meat after 24 h post-mortem ($pH_{24}$), instrumental meat tenderness (WB) and colour ($L^*$, $a^*$, $b^*$). There were significant differences in the following: $L^*$ (R1 = R4<R2 = R3), $a^*$ (R1>R4>R2 = R3), $b^*$ (R1 = R4<R2 = R3), WB (R2>R1 = R3 = R4), $pH_{24}$ (R1 = R4>R2 = R3). The relative percentages of FCSA were as follows: I (R4>R1>R3>R2), IIA (R1>R4>R3>R2), IIX (R1 = R2 = R3 = R4) and IIB (R2>R3>R1>R4). The correlation values were statistically significant between IIB and WB (R1 and R4, $r_s$ = 0.66), (R2 and R3 $r_s$ = 0.74), IIB and $L^*$ (R1 and R4 $r_s$ = 0.84), IIX and $L^*$ without discriminating NMCs. Our data suggest that the NMC where the sampling takes place is important for determining meat quality traits because of the heterogeneity of the whole muscle.
마르시아 모라에스(M. C. da S. Moraes),엘사 삼파이오(E. Sampaio),히까르도 테노리오(R. S. Tenó,rio),윤홍주(Hong-Joo Yoon),권병혁(Byung-Hyuk Kwon) 한국전자통신학회 2020 한국전자통신학회 논문지 Vol.15 No.1
Brazil Alagoas 주의 동부 지역에서 우적 크기를 측정하는 디즈드로미터(disdrometer)로 산출한 강우량과 강우율의 관계로 우적의 역학 에너지가 예측되었다. 강우의 시작과 끝에서 측정되는 약한 강우 강도에서는 지수 형태의 방정식이 큰 우적의 영향을 억제하였다. 빗방울의 역학 에너지는 거의 모든 강우 강도 범위에서 과소평가 되었다. 결정 계수, 평균 절대 오차, 상대 오차 비율, 평균 절대 오차, 평균 제곱 오차, Willmott의 일치지수 및 신뢰 지수와 같은 성과 지표에 기반을 두어 예측된 강우 역학 에너지가 유용한 결과로 평가되었다. The kinetic energy of the rain drops was predicted in a relation between the rain rate and rain quantity, derived directly from the rain drop size distribution (DSD), which had been measured by a disdrometer located in the eastern state of Alagoas-Brazil. The equation in the form of exponential form suppressed the effects of large drops at low rainfall intensity observed at the beginning and end of the rainfall. The kinetic energy of the raindrop was underestimated in almost rain intensity ranges and was considered acceptable by the performance indicators such as coefficient of determination, average absolute error, percent relative error, mean absolute error, root mean square error, Willmott s concordance index and confidence index.
López-Cánovas Juan L.,Hermán-Sánchez Natalia,del Rio-Moreno Mercedes,Fuentes-Fayos Antonio C.,Lara-López Araceli,Sánchez-Frias Marina E.,Amado Víctor,Ciria Rubén,Briceño Javier,de la Mata Manuel,Casta 생화학분자생물학회 2023 Experimental and molecular medicine Vol.55 No.-
Hepatocellular carcinoma (HCC) pathogenesis is associated with alterations in splicing machinery components (spliceosome and splicing factors) and aberrant expression of oncogenic splice variants. We aimed to analyze the expression and potential role of the spliceosome component PRPF8 (pre-mRNA processing factor 8) in HCC. PRPF8 expression (mRNA/protein) was analyzed in a retrospective cohort of HCC patients (n = 172 HCC and nontumor tissues) and validated in two in silico cohorts (TCGA and CPTAC). PRPF8 expression was silenced in liver cancer cell lines and in xenograft tumors to understand the functional and mechanistic consequences. In silico RNAseq and CLIPseq data were also analyzed. Our results indicate that PRPF8 is overexpressed in HCC and associated with increased tumor aggressiveness (patient survival, etc.), expression of HCC-related splice variants, and modulation of critical genes implicated in cancer-related pathways. PRPF8 silencing ameliorated aggressiveness in vitro and decreased tumor growth in vivo. Analysis of in silico CLIPseq data in HepG2 cells demonstrated that PRPF8 binds preferentially to exons of protein-coding genes, and RNAseq analysis showed that PRPF8 silencing alters splicing events in multiple genes. Integrated and in vitro analyses revealed that PRPF8 silencing modulates fibronectin (FN1) splicing, promoting the exclusion of exon 40.2, which is paramount for binding to integrins. Consistent with this finding, PRPF8 silencing reduced FAK/AKT phosphorylation and blunted stress fiber formation. Indeed, HepG2 and Hep3B cells exhibited a lower invasive capacity in membranes treated with conditioned medium from PRPF8-silenced cells compared to medium from scramble-treated cells. This study demonstrates that PRPF8 is overexpressed and associated with aggressiveness in HCC and plays important roles in hepatocarcinogenesis by altering FN1 splicing, FAK/AKT activation and stress fiber formation.
Cast Aluminum Surface Reinforced with Carbon Nanotube via Solubilization Treatment
Paulo R. O. Brito,Cristhian R. L. Loayza,Mário E. S. Sousa,Eduardo M. Braga,Rômulo S. Angélica,Simone P. A. da Paz,Marcos A. L. Reis 대한금속·재료학회 2022 METALS AND MATERIALS International Vol.28 No.3
Carbon nanotubes (CNTs) are noteworthy, as they reinforce the metallic matrix, due to mechanical properties, such asthe ~ 1.0 TPa Young module. To improve the maintenance of the commercially pure aluminum surface, multi-walled carbonnanotubes were incorporated into the aluminum surface with heat treatment by solid solubilization, in order to improvethe surface properties of aluminum. The aluminum samples were chemically attacked for 30, 60 and 120 s and placed in acontainer with CNTs, being subjected to a temperature of 640 °C for 1 h. Then, the roughness was evaluated by a roughnessmeter for morphology in the scanning electron microscopy. An intensity of aggregation of CNTs was evaluated by XRD, andthe Raman Spectra has evaluated the transfer of charge to the matrix. Microhardness was performed to evaluate the influenceof the incorporation of CNTs in the matrix. The results obtained show that the incorporation of CNTs in the aluminummatrix increases the hardness in approximately 20% of the surface, in comparison with the control sample. The process ofincorporating CNTs into the aluminum matrix by solubilization is a promising, simple and inexpensive alternative to improvethe durability of the aluminum surface.