http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Preparation and in vivo evaluation of immediate-release pellet containing celecoxib solid dispersion
Park, Chun-Woong,Tung, Nguyen-Thach,Son, Dao-Danh,Kim, Ju-Young,Rhee, Yun-Seok,Kang, Seung-Yeop,Park, Shin-Ae,Hwang, Kyu-Mok,Oh, Tack-Oon,Ha, Jung-Myung,Chi, Sang-Cheol,Park, Eun-Seok 한국약제학회 2012 Journal of Pharmaceutical Investigation Vol.42 No.3
The aim of this study was to make use of small size of immediate-release (IR) pellet and amorphous state of solid dispersion to increase solubility of celecoxib (CLX), a drug in BCS class II. Primary, binary and ternary solid dispersions were developed to choose the final components for solid dispersion. A ternary novel solid dispersion was prepared by incorporation of one aqueous soluble polymer (povidone k17; PVP 17PF), Methacrylate copolymer-based gastric soluble polymer ($Eudragit^{(R)}$ EPO) and one pH modulator (MgO). This combination was effective to increase solubility in pH 1.2 up to 25-30 %. The mechanism of solubility enhancement was proven by DSC, PRXD, and FT-IR. Accordingly, hydrogen bonding or electrostatic interaction of CLX with PVP/$Eudragit^{(R)}$ EPO was the main cause to form the amorphous state of CLX within polymer cluster which increasing solubility of drug. Besides, MgO played an important role to change microenviroment for solid dispersion. Pellets containing this solid dispersion were prepared by extrusion and spheronization technique. Effect of four kinds of additive (calcium hydrogen phosphate dihydrate,$NaHCO_3$, crospovidone, and sodium dodecyl sulfate) on dissolution of CLX from IR pellet was also determined. Because of highest dissolution rate, formulation using sodium dodecyl sulfate was used for pharmacokinetics study. Solid dispersion-IR pellet formulation presented bioequivalence and lower variability in comparison with reference product.
Three Cases of Synchronous Solid Tumor and Multiple Myeloma
Sang Hoon Ji,이지연,Mi Jung Oh,Keun Woo Park,Kihyun Kim,정철원,Young-Hyuck Im,Keunchil Park,oon Oh Park,임도형,Se-Hoon Lee,Young Suk Park,Mark H Lee,박병배,Won Seog Kim,Won Ki Kang 대한암학회 2004 Cancer Research and Treatment Vol.36 No.5
The association between a multiple myeloma and a secondary solid tumor is not well established. Some reports showed an increased risk of secondary solid neoplasms in multiple myeloma patients, but others have not. Three cases of the synchronous occurrence of multiple myelomas and solid tumors, namely, a small cell carcinoma of the lung, an adenocarcinoma of the colon and a squamous carcinoma of the pyriform sinus were experienced at our hospital. Therefore, herein is reported the clinical courses and treatment results. The stage of multiple myeloma was Durie-Salmon stage I in all of three cases; therefore, the solid tumors were treated as a primary target because the prognosis of early stage multiple myeloma is generally better than that of advanced solid tumor, while a smoldering or stage I myeloma do not need primary therapy until progression of the multiple myeloma. Two patients died of their solid tumors, but one patient is alive. (Cancer Res Treat. 2004;36:338-340)
Oh, Chang-Hyun,Park, Chong-Oon,Hyun, Dong-Keun,Park, Hyung-Chun,Yoon, Seung-Hwan The Korean Neurosurgical Society 2008 Journal of Korean neurosurgical society Vol.44 No.4
Objective : The cranioplasty and ventriculoperitoneal (VP) shunt operation have been used to treat a large cranial defect with posttraumatic hydrocephalus (PTH). The aim of this study was to evlauate the difference of outcomes between in the shunting after the cranioplasty (group 1) and the cranioplasty after the shunting (group 2) in a large flaccid cranial defect with PTH. Methods : In this study, a retrospective review was done on 23 patients undergoing the cranioplasty and VP shunt operation after the decompressive craniectomy for a refractory intracranial hypertension from 2002 to 2005. All of 23 cases had a large flaccid concave cranial defect and PTH. Ten cases belong to group 1 and 13 cases to group 2. The outcomes after operations were compared in two groups 6 months later. Results : The improvement of Glasgow outcome scale (GOS) was seen in 8 cases (80.0%) of total 10 cases in group 1, and 6 cases (46.2%) of 13 cases in group 2. Three (75.0%) of 4 cases with hemiparesis in group 1 and 3 of 6 cases (50.0%) in group 2 were improved. All cases (2 cases) with decrease of visual acuity were improved in each group. Dysphasia was improved in 3 of 5 cases (60%) in group 1 and 4 of 6 cases (66.6%) in group 2. Conclusion : These results suggest that outcomes in group 1 may be better than in group 2 for a large flaccid concave cranial defect with PTH.
Oh, Chang Hyun,Shim, Yu Shik,Yoon, Seung Hwan,Park, Hyeong-Chun,Park, Chong Oon,Lee, Myoung Seok The Korean Neurosurgical Society 2013 Journal of Korean neurosurgical society Vol.53 No.1
Objective : There are few published studies which have documented psychopathological abnormalities in patients with of adolescent idiopathic scoliosis (AIS) The aim of this study was to evaluate the psychopathological influence of AIS in Korean 19-year-old males. Methods : The authors compared the Korean military multiphasic personal inventory (KMPI) military profiles of 105 AIS cases (more than 10 degrees of Cobb's angle without surgical treatment) with the KMPI profiles of 108 normal controls. The AIS group was split depending on Cobb's angle to further evaluate this relation by the severity of AIS. Results : A significantly decreased result on the faking-good response scale and an significantly increased result on the faking-bad response were observed in the AIS group compared to the control (p<0.012). The neurosis scale results, including anxiety, depression and somatization symptoms, were significantly increased in the AIS group compared to the control (p<0.010). The severity level of personality disorder and schizophrenia were also significantly increased in the AIS group (p<0.010). Differences in KMPI scale scores were not related to the severity of AIS. Conclusion : Young males with AIS tend to have abnormal results on the multiphasic personal inventory test compared to normal volunteers, suggesting that AIS may be related to psychopathology in the young male group in Korea. Although these psychopathology in AIS were differently observed compared to normal controls, but not interfered with military life. Clinicians are recommended to pay attention the psychopathological traits of patients with AIS.
Park, Chun-Woong,Kim, Ju-Young,Rhee, Yun-Seok,Oh, Tack-Oon,Ha, Jeong-Myung,Park, Eun-Seok Informa Healthcare 2012 Drug development and industrial pharmacy Vol.38 No.10
<P>The objective of this study was to achieve an optimal formulation of spray dried matrix type controlled-release (MTCR) microparticles containing tamsulosin hydrochloride for orally disintegrating tablet. To control the release rate of tamsulosin hydrochloride, Acrylate-methacrylate copolymer (Eudragit<SUP>®</SUP> L-100 or Eudragit<SUP>®</SUP> S-100) and ethylcellulose were employed on the composition of MTCR microparticles. Physicochemical properties of MTCR microparticles such as particle size and SEM were characterized. Pharmacokinetic parameters of tamsulosin hydrochloride were evaluated in the rats after oral administration. MTCR microparticles were spherical microparticles of around 10 µm diameter with a corrugated surface. ODTs containing MTCR microparticles were disintegrated within 30 s and MTCR microparticles were able to control the release rate of tamsulosin hydrochloride following Fickian diffusion mechanism. The <I>in vitro</I> release rates of tamsulosin hydrochloride from MTCR microparticles were proportional to the ratio of Acrylate-methacrylate copolymer to ethylcellulose. Moreover, MTCR microparticles retarded the <I>in vivo</I> release rate of tamsulosin hydrochloride without reducing the bioavailability. Our results suggest that MTCR microparticles may be potential oral dosage forms to control the release and to improve the bioavailability of tamsulosin hydrochloride.</P>
Rhee, Yun-Seok,Park, Seok,Lee, Tae-Won,Park, Chun-Woong,Nam, Tae-Young,Oh, Tack-Oon,Jeon, Ji-Woong,Han, Sang-Beom,Lee, Dong-Soo,Park, Eun-Seok 대한약학회 2008 Archives of Pharmacal Research Vol.31 No.7
The aim of this study was to examine the in vitro/in vivo relationship of the drug release behavior of a sustained-release formulation of gabapentin. The immediate-release formulation was used as the reference formulation. The dissolution test was employed using pH 1.2, 4.0, or 6.8 buffer solution, or water, to determine the in vitro release behaviors of gabapentin tablets. Gabapentin was released completely within 1 h from the immediate-release tablet and released for 12 h from the sustained-release tablet. A single dose (600 mg) of each formulation was orally administered to four beagle dogs under fasted conditions, and the pharmacokinetic parameters were calculated. Although the sustained-release tablet did not disintegrate and had slow drug release characteristics, it showed similar pharmacokinetic parameters to the immediate-release tablet, which rapidly disintegrated and showed fast drug release. Thus, the in vivo release of gabapentin did not correlate with in vitro release of drug.
Rhee, Yun-Seok,Park, Seok,Lee, Tae-Won,Park, Chun-Woong,Nam, Tae-Young,Oh, Tack-Oon,Jeon, Ji-Woong,Lee, Dong-Soo,Park, Eun-Seok 대한약학회 2008 Archives of Pharmacal Research Vol.31 No.6
Acamprosate calcium is a highly soluble drug with low permeability that is used to maintain abstinence in alcohol-dependent patients. The aim of this study was to investigate the relationship between in vitro and in vivo behaviors of acamprosate from enteric-coated tablets. The in vitro release behavior of acamprosate tablets in pH 6.8 buffer solution was determined in three dissolution conditions, 50 and 150 rpm (paddle method) and 180 rpm (basket method). The results of this in vitro experiment indicated that acamprosate tablets hardly disintegrated, and drug dissolution was retarded despite the extremely hydrophilic nature of the drug. A single dose ($333\;mg{\times}2$ tablets) of each formulation was orally administered to four beagle dogs under fasting conditions, and the pharmacokinetic parameters were calculated. The mean $AUC_{0-48}$, $C_{max}$, $T_{lag}$ and $T_{max}$ for the two types of tablets ranged from $41.5-53.6\;{\mu}g{\cdot}h/mL$, $4.3-4.5\;{\mu}g/mL$, 2.0-2.5 h and 3.8-4.0 h, respectively. In conclusion, it is suggested that retarded drug release from the tablets and the low drug permeability may result in poor absorption and erratic bioavailability of this drug in humans.
Effects of metal- and fiber-reinforced composite root canal posts on flexural properties
Kim, Su-Hyeon,Oh, Tack-Oon,Kim, Ju-Young,Park, Chun-Woong,Baek, Seung-Ho,Park, Eun-Seok JAPANESE SOCIETY FOR DENTAL MATERIALS AND DEVICES 2016 Dental materials journal Vol.35 No.1
<P>The aim of this study was to observe the effects of different test conditions on the flexural properties of root canal post. Metal and fiber-reinforced composite root canal posts of various diameters were measured to determine flexural properties using a three-point bending test at different conditions. In this study, the span length/post diameter ratio of root canal posts varied from 3.0 to 10.0. Multiple regression models for maximum load as a dependent variable were statistically significant. The models for flexural properties as dependent variables were statistically significant, but linear regression models could not be fitted to data sets. At a low span length/post diameter ratio, the flexural properties were distorted by occurrence of shear stress in short samples. It was impossible to obtain high span length/post diameter ratio with root canal posts. The addition of parameters or coefficients is necessary to appropriately represent the flexural properties of root canal posts.</P>
Yun-Seok Rhee,Seok Park,Tae-Won Lee,Chun-Woong Park,Tae-Young Nam,Tack-Oon Oh,Ji-Woong Jeon,Dong-Soo Lee,Eun-Seok Park 대한약학회 2008 Archives of Pharmacal Research Vol.31 No.6
Acamprosate calcium is a highly soluble drug with low permeability that is used to maintain abstinence in alcohol-dependent patients. The aim of this study was to investigate the relationship between in vitro and in vivo behaviors of acamprosate from enteric-coated tablets. The in vitro release behavior of acamprosate tablets in pH 6.8 buffer solution was determined in three dissolution conditions, 50 and 150 rpm (paddle method) and 180 rpm (basket method). The results of this in vitro experiment indicated that acamprosate tablets hardly disintegrated, and drug dissolution was retarded despite the extremely hydrophilic nature of the drug. A single dose (333 mg×2 tablets) of each formulation was orally administered to four beagle dogs under fasting conditions, and the pharmacokinetic parameters were calculated. The mean AUC0-48, Cmax, Tlag and Tmax for the two types of tablets ranged from 41.5-53.6 μg·h/mL, 4.3-4.5 μg/mL, 2.0-2.5 h and 3.8-4.0 h, respectively. In conclusion, it is suggested that retarded drug release from the tablets and the low drug permeability may result in poor absorption and erratic bioavailability of this drug in humans.