Global Overview of the Transnational Alliance for Regenerative Therapies in Cardiovascular Syndromes (TACTICS) Recommendations

Fern&aacute,ndez-Avilé,s, Francisco,Sanz-Ruiz, Ricardo,Climent, Andreu M.,Badimon, Lina,Bolli, Roberto,Charron, Dominique,Fuster, Valentin,Janssens, Stefan,Kastrup, Jens,Kim, Hyo-Soo,Lü,sche American Heart Foundation 2018 Circulation research Vol.122 No.2

HIGHEST REDSHIFT IMAGE OF NEUTRAL HYDROGEN IN EMISSION: A CHILES DETECTION OF A STARBURSTING GALAXY AT <i>z</i> = 0.376

Fern&aacute,ndez, Ximena,Gim, Hansung B.,Gorkom, J. H. van,Yun, Min S.,Momjian, Emmanuel,Popping, Attila,Chomiuk, Laura,Hess, Kelley M.,Hunt, Lucas,Kreckel, Kathryn,Lucero, Danielle,Maddox, Natasha,Oo American Astronomical Society 2016 ASTROPHYSICAL JOURNAL LETTERS - Vol.824 No.1

<P>Our current understanding of galaxy evolution still has many uncertainties associated with the details of the accretion, processing, and removal of gas across cosmic time. The next generation of radio telescopes will image the neutral hydrogen (H I) in galaxies over large volumes at high redshifts, which will provide key insights into these processes. We are conducting the COSMOS H I Large Extragalactic Survey (CHILES) with the Karl G. Jansky Very Large Array, which is the first survey to simultaneously observe H I from z = 0 to z similar to 0.5. Here, we report the highest redshift H I 21 cm detection in emission to date of the luminous infrared galaxy COSMOS J100054.83+023126.2 at z = 0.376 with the first 178 hr of CHILES data. The total H I mass is (2.9 +/- 1.0) x 10(10) M-circle dot and the spatial distribution is asymmetric and extends beyond the galaxy. While optically the galaxy looks undisturbed, the H I distribution suggests an interaction with a candidate companion. In addition, we present follow-up Large Millimeter Telescope CO observations that show it is rich in molecular hydrogen, with a range of possible masses of (1.8-9.9) x 10(10) M-circle dot. This is the first study of the H I and CO in emission for a single galaxy beyond z similar to 0.2.</P>

Deep SDSS optical spectroscopy of distant halo stars : II. Iron, calcium, and magnesium abundances⋆⋆⋆

Fern&aacute,ndez-Alvar, E.,Allende Prieto, C.,Schlesinger, K. J.,Beers, T. C.,Robin, A. C.,Schneider, D. P.,Lee, Y. S.,Bizyaev, D.,Ebelke, G.,Malanushenko, E.,Malanushenko, V.,Oravetz, D.,Pan, K.,Simm EDP Sciences 2015 Astronomy and astrophysics Vol.577 No.-

Active tailoring of nanoantenna plasmonic fields using few-cycle laser pulses

Choi, S.,Ciappina, M. F.,Pé,rez-Hern&aacute,ndez, J. A.,Landsman, A. S.,Kim, Y.-J.,Kim, S. C.,Kim, D. American Physical Society 2016 Physical Review A Vol.93 No.2

<P>Plasmonic nanoatennas are a versatile tool for coherently manipulating light on a nanoscale by confining electric fields of the driving laser into subwavelength volumes, thereby significantly enhancing electric near fields. It is normally assumed that the time-dependent spectral properties of these near fields are independent of the duration of the driving laser pulse. Here we show that when a few-cycle laser pulse shines on a bow-tie nanoantenna, its spectral properties are dramatically modified, as evidenced by a large shift of the center wavelength of the near field, relative to the driving laser. In addition, for certain geometries, a second color appears in the near field, creating conditions for generation of an isolated attosecond pulse at megahertz repetition rate. Our results open the door to frequency-tunable ultrafast sources at nanometer scale without tuning the frequency of the driving laser.</P>

Hippocampal morphology and cognitive functions in community-dwelling older people: the Lothian Birth Cohort 1936

Valdé,s Hern&aacute,ndez, Maria del Carmen,Cox, Simon R.,Kim, Jaeil,Royle, Natalie A.,Muñ,oz Maniega, Susana,Gow, Alan J.,Anblagan, Devasuda,Bastin, Mark E.,Park, Jinah,Starr, John M.,Ward Elsevier 2017 NEUROBIOLOGY OF AGING Vol.52 No.-

<P>Structural measures of the hippocampus have been linked to a variety of memory processes and also to broader cognitive abilities. Gross volumetry has been widely used, yet the hippocampus has a complex formation, comprising distinct subfields which may be differentially sensitive to the deleterious effects of age, and to different aspects of cognitive performance. However, a comprehensive analysis of multidomain cognitive associations with hippocampal deformations among a large group of cognitively normal older adults is currently lacking. In 654 participants of the Lothian Birth Cohort 1936 (mean age = 72.5, SD = 0.71 years), we examined associations between the morphology of the hippocampus and a variety of memory tests (spatial span, letter-number sequencing, verbal recall, and digit backwards), as well as broader cognitive domains (latent measures of speed, fluid intelligence, and memory). Following correction for age, sex, and vascular risk factors, analysis of memory subtests revealed that only right hippocampal associations in relation to spatial memory survived type 1 error correction in subiculum and in CA1 at the head (<I>β</I> = 0.201, <I>p</I> = 5.843 × 10<SUP>−4</SUP>, outward), and in the ventral tail section of CA1 (<I>β</I> = −0.272, <I>p</I> = 1.347 × 10<SUP>−5</SUP>, inward). With respect to latent measures of cognitive domains, only deformations associated with processing speed survived type 1 error correction in bilateral subiculum (<I>β</I><SUB><I>absolute</I></SUB> ≤ 0.247, <I>p</I> < 1.369 × 10<SUP>−4</SUP>, outward), bilaterally in the ventral tail section of CA1 (<I>β</I><SUB><I>absolute</I></SUB> ≤ 0.242, <I>p</I> < 3.451 × 10<SUP>−6</SUP>, inward), and a cluster at the left anterior-to-dorsal region of the head (<I>β</I> = 0.199, <I>p</I> = 5.220 × 10<SUP>−6</SUP>, outward). Overall, our results indicate that a complex pattern of both inward and outward hippocampal deformations are associated with better processing speed and spatial memory in older age, suggesting that complex shape-based hippocampal analyses may provide valuable information beyond gross volumetry.</P>

Yaw motion analysis of a FPSO turret mooring system under wave drift forces

Sanchez-Mondragon, J.,V&aacute,zquez-Hern&aacute,ndez, A.O.,Cho, S.K.,Sung, H.G. Elsevier 2018 Applied ocean research Vol.74 No.-

<P><B>Abstract</B></P> <P>In order to evaluate the dynamic behavior of a FPSO-turret system, experimental tests in engineering wave basin have been performed. During the realization of experimental test large slow yaw rotations were detected in the dynamic behavior of the vessel during regular and irregular wave conditions tests. In order to study this phenomenon, an analytical method was developed in order to predict the maximum yaw angle reached under the slow yaw varying oscillations of a single point moored FPSO-turret system dependent of the regular mean wave drift forces and the turret position. The results for the proposed analytical method were verified by comparing it with experimental and simulated results. Then, the proposed method allows to identify the critical regular wave periods than can provoke large yaw rotations as an alternative for the stability tests by bifurcation analysis. On the other hand, the performed yaw motion simulations take into account the following aspects: the turret position, and the force and momentum associated with the mooring system variations (in function of the FPSO center of gravity positions and regular mean wave drift forces). Analyzing the time domain simulations it is possible to identify that large yaw motion is reached faster when the turret is near the CG and so, as the turret moves away, the yaw motions become slower.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Analytical yaw stability condition is developed. </LI> <LI> FPSO-turret dynamic study under wave drift forces on regular wave conditions. </LI> <LI> Numerical simulations and experimental results compared the yaw stability condition. </LI> <LI> Turret position configuration variations associated with yaw instabilities. </LI> </UL> </P>

3D shape analysis of the brain's third ventricle using a midplane encoded symmetric template model

Kim, Jaeil,Valdé,s Hern&aacute,ndez, Maria del C.,Royle, Natalie A.,Maniega, Susana Muñ,oz,Aribisala, Benjamin S.,Gow, Alan J.,Bastin, Mark E.,Deary, Ian J.,Wardlaw, Joanna M.,Park, Jinah Elsevier Scientific Publishers 2016 COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE Vol.129 No.-

<▼1><P><B>Highlights</B></P><P>•<P>Present a model-based approach to investigate the morphology of the third ventricle.</P>•<P>Assess the regional deformations in relation to the atrophy of surrounding structures.</P>•<P>Use a symmetric template model with the midplane definition for unbiased analysis.</P>•<P>Achieve a robust surface modeling using a progressive surface deformation.</P>•<P>Validate the method on a healthy aging sample with different clinical variables.</P></P></▼1><▼2><P><B>Background</B></P><P>Structural changes of the brain's third ventricle have been acknowledged as an indicative measure of the brain atrophy progression in neurodegenerative and endocrinal diseases. To investigate the ventricular enlargement in relation to the atrophy of the surrounding structures, shape analysis is a promising approach. However, there are hurdles in modeling the third ventricle shape. First, it has topological variations across individuals due to the inter-thalamic adhesion. In addition, as an interhemispheric structure, it needs to be aligned to the midsagittal plane to assess its asymmetric and regional deformation.</P><P><B>Method</B></P><P>To address these issues, we propose a model-based shape assessment. Our template model of the third ventricle consists of a midplane and a symmetric mesh of generic shape. By mapping the template's midplane to the individuals’ brain midsagittal plane, we align the symmetric mesh on the midline of the brain before quantifying the third ventricle shape. To build the vertex-wise correspondence between the individual third ventricle and the template mesh, we employ a minimal-distortion surface deformation framework. In addition, to account for topological variations, we implement geometric constraints guiding the template mesh to have zero width where the inter-thalamic adhesion passes through, preventing vertices crossing between left and right walls of the third ventricle. The individual shapes are compared using a vertex-wise deformity from the symmetric template.</P><P><B>Results</B></P><P>Experiments on imaging and demographic data from a study of aging showed that our model was sensitive in assessing morphological differences between individuals in relation to brain volume (i.e. proxy for general brain atrophy), gender and the fluid intelligence at age 72. It also revealed that the proposed method can detect the regional and asymmetrical deformation unlike the conventional measures: volume (median 1.95 ml, IQR 0.96 ml) and width of the third ventricle. Similarity measures between binary masks and the shape model showed that the latter reconstructed shape details with high accuracy (Dice coefficient ≥0.9, mean distance 0.5 mm and Hausdorff distance 2.7 mm).</P><P><B>Conclusions</B></P><P>We have demonstrated that our approach is suitable to morphometrical analyses of the third ventricle, providing high accuracy and inter-subject consistency in the shape quantification. This shape modeling method with geometric constraints based on anatomical landmarks could be extended to other brain structures which require a consistent measurement basis in the morphometry.</P></▼2>

An equatorial ultra iron-poor star identified in BOSS

Allende Prieto, C.,Fern&aacute,ndez-Alvar, E.,Aguado, D. S.,Gonz&aacute,lez Hern&aacute,ndez, J. I.,Rebolo, R.,Lee, Y. S.,Beers, T. C.,Rockosi, C. M.,Ge, J. EDP Sciences 2015 Astronomy and astrophysics Vol.579 No.-

The pulsating hot subdwarf Balloon 090100001: results of the 2005 multisite campaign

Baran, A.,Oreiro, R.,Pigulski, A.,Hern&aacute,ndez, F. Pé,rez,Ulla, A.,Reed, M. D.,Rodrí,guez-Ló,pez, C.,Moskalik, P.,Kim, S.-L.,Chen, W.-P.,Crowe, R.,Siwak, M.,Armendarez, L.,Binder Blackwell Publishing Ltd 2009 MONTHLY NOTICES- ROYAL ASTRONOMICAL SOCIETY Vol.392 No.3

<P>ABSTRACT</P><P>We present the results of a multisite photometric campaign on the pulsating B-type hot subdwarf star Balloon 090100001 (Bal09). The star is one of the two known hybrid hot subdwarfs with both long- and short-period oscillations, theoretically attributed to <I>g</I> and <I>p</I> modes. The campaign involved eight telescopes with three obtaining <I>UBVR</I> data, four <I>B</I>-band data and one Strömgren <I>uvby</I> photometry. The campaign covered 48 nights, providing a temporal resolution of 0.36 μHz with a detection threshold of about 0.2 mmag in <I>B</I>-filter data.</P><P>Bal09 has the richest pulsation spectrum of any known pulsating subdwarf B star, and our analysis detected 114 frequencies including 97 independent and 17 combination ones. Most of the 24 <I>g</I>-mode frequencies are between 0.1 and 0.4 mHz. Of the remaining 73, presumably <I>p</I> modes, 72 group into four distinct regions near 2.8, 3.8, 4.7 and 5.5 mHz. The density of frequencies requires that some modes must have degrees ℓ larger than 2. The modes in the 2.8 mHz region have the largest amplitudes. The strongest mode (<I>f</I><SUB>1</SUB>) is most likely radial, while the remaining ones in this region form two nearly symmetric multiplets: a triplet and quintuplet, attributed to rotationally split ℓ= 1 and 2 modes, respectively. We find clear increases of splitting in both multiplets between the 2004 and 2005 observing campaigns, amounting to ∼15 per cent on average. The observed splittings imply that the rotational rate in Bal09 depends on stellar latitude and is the fastest on the equator. We also speculate on the possible reasons for the changes of splitting. The only plausible explanation we find is torsional oscillation. This hypothesis, however, needs to be verified in the future by detailed modelling. In this context, it is very important to monitor the splittings on a longer time-scale as their behaviour may help to explain this interesting phenomenon.</P><P>The amplitudes of almost all terms detected in both 2004 and 2005 were found to vary. This is evident even during one season; for example, amplitudes of modes <I>f</I><SUB>8</SUB> and <I>f</I><SUB>C</SUB> were found to change by a factor of 2–3 within about 50 d during 2005.</P><P>We use a small grid of models to constrain the main mode (<I>f</I><SUB>1</SUB>), which most likely represents the radial fundamental pulsation. The groups of <I>p</I>-mode frequencies appear to lie in the vicinity of the consecutive radial overtones, up to the third one. Despite the large number of <I>g</I>-mode frequencies observed, we failed to identify them, most likely because of the disruption of asymptotic behaviour by mode trapping. The observed frequencies were not, however, fully exploited in terms of seismic analysis which should be done in the future with a larger grid of reliable evolutionary models of hot subdwarfs.</P>

Associations between hippocampal morphology, diffusion characteristics, and salivary cortisol in older men

Cox, Simon R.,Valdé,s Hern&aacute,ndez, Maria del Carmen,Kim, Jaeil,Royle, Natalie A.,MacPherson, Sarah E.,Ferguson, Karen J.,Muñ,oz Maniega, Susana,Anblagan, Devasuda,Aribisala, Benjamin Pergamon Press 2017 Psychoneuroendocrinology Vol.78 No.-

<▼1><P><B>Highlights</B></P><P>•<P>Elevated cortisol does not appear to be associated with regional variations in hippocampal shape.</P>•<P>Novel shape morphology analysis applied to study possible effect of cortisol on hippocampus.</P>•<P>Mean diffusivity in hippocampus is associated with reactive cortisol slope in older men.</P></P></▼1><▼2><P>High, unabated glucocorticoid (GC) levels are thought to selectively damage certain tissue types. The hippocampus is thought to be particularly susceptible to such effects, and though findings from animal models and human patients provide some support for this hypothesis, evidence for associations between elevated GCs and lower hippocampal volumes in older age (when GC levels are at greater risk of dysregulation) is inconclusive. To address the possibility that the effects of GCs in non-pathological ageing may be too subtle for gross volumetry to reliably detect, we analyse associations between salivary cortisol (diurnal and reactive measures), hippocampal morphology and diffusion characteristics in 88 males, aged ∼73 years. However, our results provide only weak support for this hypothesis. Though nominally significant peaks in morphology were found in both hippocampi across all salivary cortisol measures (standardised <I>β</I> magnitudes < 0.518, <I>p<SUB>uncorrected</SUB></I> > 0.0000003), associations were both positive and negative, and none survived false discovery rate correction. We found one single significant association (out of 12 comparisons) between a general measure of hippocampal diffusion and reactive cortisol slope (<I>β</I> <I>=</I> 0.290, <I>p</I> = 0.008) which appeared to be driven predominantly by mean diffusivity but did not survive correction for multiple testing. The current data therefore do not clearly support the hypothesis that elevated cortisol levels are associated with subtle variations in hippocampal shape or microstructure in non-pathological older age.</P></▼2>