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A new saponin from Acanthopanax koreanum with anti-inflammatory activity
leducdat,Nguyen Phuong Thao,Bui Thi Thuy Luyen,BUIHUU TAI,우미희,Zahid Manzoor,Irshad Ali,고영상,김영호 대한약학회 2017 Archives of Pharmacal Research Vol.40 No.3
Twelve saponins were isolated from the leavesof Acanthopanax koreanum, including one new lupanetypetriterpene glycoside, named acankoreoside R (1),together with 11 known triterpenoid saponins (2–12). Theirstructures were elucidated by 1D and 2D nuclear magneticresonance (NMR), mass spectroscopic data (MS). All ofthe fractions and isolated saponins were evaluated for antiinflammatoryactivities in lipopolysaccharide (LPS)-stimulatedbone marrow-derived dendritic cells (BMDCs) byELISA. Among them, compounds 1–5, 7, 10, and 12showed strong inhibitions towards interleukin-12 (IL-12)production with IC50 values ranging from 1.59 to 5.46 lM. Other compounds were weak or inactive toward IL-12 p40production.
Anti-inflammatory Triterpenes and Glyceryl Glycosides from Kandelia candel (L.) Druce
Le Duc Dat,NGUYEN PHUONG THAO,BUIHUU TAI,Bui Thi Thuy Luyen,양서영,김소현,구정은,고영상,Nguyen The Cuong,Nguyen Hoai Nam,Nguyen Van Thanh,Phan Van Kiem,Chau Van Minh,김영호 한국생약학회 2015 Natural Product Sciences Vol.21 No.3
Phytochemical investigation of Kandelia candel resulted in the isolation of six triterpenes (1 - 5) and two glyceryl glycosides (6 and 7) and their structures were determined by comparing the spectroscopic data with those of reported values. In present study, we described the inhibitory effects of fractions and isolated compounds from K. candel on pro-inflammatory cytokines (IL-12 p40, IL-6, and TNF-a) production in lipopolysaccharide (LPS) stimulated bone marrow-derived dendritic cells (BMDCs). Results indicated that compounds 3, 6, and 7 showed potent inhibition on IL-6 production (IC50 values at less than 0.5 mM, respectively). Meanwhile, compounds 6 and 7 exhibited strong inhibitory effects on the production of TNF-a (IC50 values of 1.7 ? 0.1 and 5.5 ? 0.2 mM). Compounds 1 and 3 were also showed the inhibitory effects on IL-12 p40 production (IC50 values of 8.9 ? 0.4 and 3.3 ? 0.1 mM, respectively).