Trends and Analysis of Cancer Incidence for Common Male and Female Cancers in the Population of Punjab Province of Pakistan during 1984 to 2014

Masood, Khalid,Masood, Andleeb,Zafar, Junaid,Shahid, Abubaker,Kamran, Mujahid,Murad, Sohail,Masood, Misbah,Alluddin, Zafar,Riaz, Masooma,Akhter, Naseem,Ahmad, Munir,Ahmad, Fayyaz,Akhtar, Javaid,Naeem, Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.13

Background: The Pakistan Atomic Energy Commission Cancer Registry (PAECCR) program has made availability of a common cancer incidence database possible in Pakistan. The cancer incidence data from nuclear medicine and oncology institutes were gathered and presented. Materials and Methods: The cancer incidence data for the last 30 years (1984-2014) are included to describe a data set of male and female patients. The data analysis concerning occurrence, trends of common cancers in male and female patients, stage-wise distribution, and mortality/follow-up cases is also incorporated for the last 10 years (2004-2014). Results: The total population of provincial capital Lahore is 9,800,000. The total number of cancer cases was 80,390 (males 32,156, females 48,134). The crude incidence rates in PAECCR areas were 580.8/$10^5$ during 2010 to 885.4/$10^5$ in 2014 (males 354.1/$10^5$, females 530.1/$10^5$). The cancer incidence rates for head and neck (15.70%), brain tumors (10.5%), and non-Hodgkin lymphoma (NHL, 9.53%) were found to be the highest in male patients, whereas breast cancer (46.7%), ovary tumors (6.80%), and cervix (6.31%) cancer incidence rates were observed to be the most common in female patients. The age range distribution of diagnosed and treated patients in conjunction with the percentage contribution of cancer patients from 15 different cities of Punjab province treated at the Institute of Nuclear Medicine and Oncology, Lahore are also included. Leukemia was found to be the most common cancer for the age group of 1-12 years. It has been identified that the maximum number of diagnosed cases were found in the age range of 51-60 years for males and 41-50 years for female cancer patients. Conclusions: Overall cancer incidence of the thirty years demonstrated that head and neck and breast cancers in males and in females respectively are the most common cancers in Punjab province in Pakistan, at rates almost the highest in Asia, requiring especial attention. The incidence of brain, NHL, and prostate cancers among males and ovarian and cervix cancers among females have increased rapidly. These data from a major population of Punjab province should be helpful for implementation of appropriate planning, prevention and cancer control measures and for determination of risk factors within the country.

Advanced Business Process Management with Digital Innovations (Review)

Masood Ahmed Khalid,Muhammad Jawad Ibrahim International Journal of Computer ScienceNetwork S 2023 International journal of computer science and netw Vol.23 No.6

Many organizations are looking for digital innovation to apply in business process management and this information revolution leaves its effect on the businesses and anticipate competitors. In this article, investigates the strength of the relationship between business process management (BMP) and Digital Innovations (DI) since it has been underdeveloped. The results and findings are extracted from international survey with explanations of expert panel to generalized a positive and moderate link of multiple factors that are affecting the strategic decision-making in business process management. It is extended to the Technology Organization Environment (TOE) framework and contour organizations along their Digital Process Innovation (DPI).

Electroactive Polyimides: Synthesis, Characterization and Photophysics

Khalid, Naila,Siddiqi, Humaira Masood,Park, O. Ok Informa UK (TaylorFrancis) 2017 Polymer-plastics technology and engineering Vol.56 No.8

<P>.</P>

Screening for Lynch Syndrome in Young Colorectal Cancer Patients from Saudi Arabia Using Microsatellite Instability as the Initial Test

Alqahtani, Masood,Grieu, Fabienne,Carrello, Amerigo,Amanuel, Benhur,Mashour, Miral,Alattas, Rabab,Al-Saleh, Khalid,Alsheikh, Abdulmalik,Alqahtani, Sarah,Iacopetta, Barry Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.4

Background: Lynch Syndrome (LS) is a familial cancer condition caused by germline mutations in DNA mismatch repair genes. Individuals with LS have a greatly increased risk of developing colorectal cancer (CRC) and it is therefore important to identify mutation carriers so they can undergo regular surveillance. Tumor DNA from LS patients characteristically shows microsatellite instability (MSI). Our aim here was to screen young CRC patients for MSI as a first step in the identification of unrecognized cases of LS in the Saudi population. Materials and Methods: Archival tumor tissue was obtained from 284 CRC patients treated at 4 institutes in Dammam and Riyadh between 2006 and 2015 and aged less than 60 years at diagnosis. MSI screening was performed using the BAT-26 microsatellite marker and positive cases confirmed using the pentaplex MSI analysis system. Positive cases were screened for BRAF mutations to exclude sporadic CRC and were evaluated for loss of expression of 4 DNA mismatch repair proteins using immunohistochemistry. Results: MSI was found in 33/284 (11.6%) cases, of which only one showed a BRAF mutation. Saudi MSI cases showed similar instability in the BAT-26 and BAT-25 markers to Australian MSI cases, but significantly lower frequencies of instability in 3 other microsatellite markers. Conclusions: MSI screening of young Saudi CRC patients reveals that approximately 1 in 9 are candidates for LS. Patients with MSI are strongly recommended to undergo genetic counselling and germline mutation testing for LS. Other affected family members can then be identified and offered regular surveillance for early detection of LS-associated cancers.

In Silico Study of Human Gap Junction Beta-2 Protein by Homology Modeling

Shehzadi, Abida,Masood, Khalid Korea Genome Organization 2010 Genomics & informatics Vol.8 No.2

Asp66his, Asp54Lys, and Asp50Asn are mutations in connexin 26 that are observed in the clinic and give rise to autosomal dominant syndromes. They are the result of point mutations in the human gap junction ${\beta}-2$ gene. In order to investigate the structural mechanism of Bart-Pumphrey Syndrome, Keratitis-Ichthyosis-Deafness Syndrome, and Vohwinkel Syndrome, homology modeling was carried out. Asp66 has direct contact with Asn62 by two hydrogen bonds in the wild-type protein, and in Asp66His, the biggest change observed is a tremendous energy increase caused by hydrogen bond breakage to Asn62. Shifts in the side chain and new hydrogen bond formation are observed for Lys54 compared to the wild-type protein (Asn54) and result in closer contact to Val84. Asp50Asn causes a significant decrease in bond energy, and residual charge reversal repels the ion and metabolites and, hence, inhibits their transportation. Such perturbations are likely to be a factor contributing to abnormal functioning of ion channels, resulting cell death and disease.

In Silico Study of Human Gap Junction Beta-2 Protein by Homology Modeling

Abida Shehzadi,Khalid Masood 한국유전체학회 2010 Genomics & informatics Vol.8 No.2

Asp66his, Asp54Lys, and Asp50Asn are mutations in connexin 26 that are observed in the clinic and give rise to autosomal dominant syndromes. They are the result of point mutations in the human gap junction β-2 gene. In order to investigate the structural mechanism of Bart-Pumphrey Syndrome, Keratitis-Ichthyosis-Deafness Syndrome, and Vohwinkel Syndrome, homology modeling was carried out. Asp66 has direct contact with Asn62 by two hydrogen bonds in the wild-type protein, and in Asp66His, the biggest change observed is a tremendous energy increase caused by hydrogen bond breakage to Asn62. Shifts in the side chain and new hydrogen bond formation are observed for Lys54 compared to the wild-type protein (Asn54) and result in closer contact to Val84. Asp50Asn causes a significant decrease in bond energy, and residual charge reversal repels the ion and metabolites and, hence, inhibits their transportation. Such perturbations are likely to be a factor contributing to abnormal functioning of ion channels, resulting cell death and disease.

Xylanolytic Modification in Wheat Flour and its Effect on Dough Rheological Characteristics and Bread Quality Attributes

Zulfiqar Ahmad,Nauman Khalid,Masood Sadiq Butt,Anwaar Ahmed 한국응용생명화학회 2013 Applied Biological Chemistry (Appl Biol Chem) Vol.56 No.6

Effects of various xylanase treatments applied at different stages of bread making process on dough rheological characteristics and bread quality attributes were investigated. Different doses (200, 400, 600, 800, and 1000 IU) of purified enzyme were applied at two stages (tempering and mixing). In milling and dough making processes, both types of flour (subjected to enzyme treatment during tempering and flour mixing) exhibited decreasing trend in water absorption, dough development time, dough stability, softening of dough, dough mixing time, viscosity peak, set back, and increasing tendency in peak height and pasting temperature. Treatments during tempering resulted in more significant effects as compared to applications during flour mixing. The dough rising during proofing resulted in enhancement from 137±3.21% (control) to maximum value (192.33±2.90%), when 600 IU of xylanases were applied to 1 kg of wheat grains during tempering. The bread sensory attributes also exhibited significant improvement in response to various doses of purified enzymes.

Xylanolytic Modification in Wheat Flour and its Effect on Dough Rheological Characteristics and Bread Quality Attributes

Ahmad, Zulfiqar,Butt, Masood Sadiq,Ahmed, Anwaar,Khalid, Nauman The Korean Society for Applied Biological Chemistr 2013 Applied Biological Chemistry (Appl Biol Chem) Vol.56 No.6

Effects of various xylanase treatments applied at different stages of bread making process on dough rheological characteristics and bread quality attributes were investigated. Different doses (200, 400, 600, 800, and 1000 IU) of purified enzyme were applied at two stages (tempering and mixing). In milling and dough making processes, both types of flour (subjected to enzyme treatment during tempering and flour mixing) exhibited decreasing trend in water absorption, dough development time, dough stability, softening of dough, dough mixing time, viscosity peak, set back, and increasing tendency in peak height and pasting temperature. Treatments during tempering resulted in more significant effects as compared to applications during flour mixing. The dough rising during proofing resulted in enhancement from $137{\pm}3.21$% (control) to maximum value ($192.33{\pm}2.90$%), when 600 IU of xylanases were applied to 1 kg of wheat grains during tempering. The bread sensory attributes also exhibited significant improvement in response to various doses of purified enzymes.

Operators that Reduce Work and Information Overload

Sabir Abbas,Shane zahra,Muhammad Asif,khalid masood International Journal of Computer ScienceNetwork S 2023 International journal of computer science and netw Vol.23 No.9

The "information roadway" will give us an impact of new PC based assignments and administrations, yet the unusualness of this new condition will ask for another style of human-PC association, where the PC transforms into a sharp, dynamic and customized partner. Interface administrators are PC programs that use Artificial Intelligence frameworks to give dynamic help to a customer with PC based errands. Operators drastically change the present client encounter, through the similitude that a specialist can go about as an individual collaborator. The operator procures its capability by gaining from the client and from specialists helping different clients. A couple of model administrators have been gathered using this methodology, including authorities that give customized help with meeting planning, electronic mail taking care of, Smart Personal Assistant and choice of diversion. Operators help clients in a scope of various ways: they perform assignments for the client's sake; they can prepare or educate the client, they enable diverse clients to work together and they screen occasions and methods.