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Rah, So-Young,Lee, Young-Hoon,Kim, Uh-Hyun Federation of American Societies for Experimental 2017 The FASEB Journal Vol.31 No.7
<P>LPS has been shown to induce hepatocyte autophagy, but little is known about how LPS is able to do this during acute toxic liver injury. Our aim was to determine the existence of any selective Ca<SUP>2+</SUP> signaling coupling to hepatocyte autophagy in response to LPS. LPS increased the autophagic process in hepatocytes, and CD38 knockdown prevented this response. Ned19, a specific inhibitor for nicotinic acid adenine dinucleotide phosphate (NAADP), prevented LPS-mediated Ca<SUP>2+</SUP> signaling and autophagosome formation in hepatocytes. CD38 overexpression protected the liver from LPS/<SMALL>D</SMALL>-galactosamine (GalN)-induced injury, and NAADP administration promoted autophagosome formation and protected hepatocytes from injury induced by LPS/GalN. Autophagy was promoted by the up-regulation of autophagy-related gene expression <I>via</I> NAADP-mediated Ca<SUP>2+</SUP> signaling in response to LPS. However, CD38-knockout mice displayed down-regulation in hepatocyte gene expression. Ned19 also inhibited the NAADP-stimulated induction of gene expression by inhibiting the LPS-induced nuclear translocation of transcription factor EB (TFEB). Hepatocyte autophagy protects against LPS-induced liver injury <I>via</I> the CD38/NAADP/Ca<SUP>2+</SUP>/TFEB pathway. The role of NAADP-mediated Ca<SUP>2+</SUP> signaling in the autophagic process will help elucidate the complexities of autophagy regulation, which is essential toward the discovery of new therapeutic tools against acute liver injury.—Rah, S.-Y., Lee, Y.-H., Kim, U.-H. NAADP-mediated Ca<SUP>2+</SUP> signaling promotes autophagy and protects against LPS-induced liver injury.</P>
Dong Hoon Lee,Sang Hoon Rah,Ie Na Yoon 대한안과학회 2009 Korean Journal of Ophthalmology Vol.23 No.4
A 32-year-old female who had undergone the silicone oil removal procedure presented with visual disturbance in her left eye. Several months previous, she had cataract surgery in a private clinic, and a month later she had a Nd:YAG laser procedure for posterior capsulotomy. The slit-lamp examination revealed silicone oil droplets that had adhered to the intraocular lens where the posterior capsulotomy was performed. She had experienced high myopia as a manifestation of the resulting refractive changes. We replaced the previous intraocular lens with a new acrylic intraocular lens with resulting improvement to her vision. Here we report the case of a female patient with a history of silicone oil removal surgery where the resulting silicone bubbles had not been removed thoroughly and remained in the vitreous cavity. These bubbles subsequently adhered to the intraocular lens following YAG laser posterior capsulotomy, resulting in refractive changes. We recommend that implanting a silicone intraocular lens in anyone with a history of the silicone oil removal procedure or who has a possible history of silicone oil use should be avoided. Korean J Ophthalmol 2009;23:309-311
羅秀均,朱鑑鎬,安秉勳 최신의학사 1973 最新醫學 Vol.16 No.1
The results of the treatment upon total of 79 cases of closed and open fracture of the tibia treated in the year 1966 through 1971 at the Department of Orthopedic Surgery, National Medical Center has been analyzed comparatively in this report. 1. Primary bony union occurred in all the cases of closed fractures of 30 cases, whereas 38 cases had primary bony union among 49 cases of open fractures. Further, 16 cases out of 25 cases of open fracture, of which wound was treated by primary closure, had primary bony union, whereas, 22 cases out of 24 cases of open fracture, of which wound was treated by delayed primary closure, had primary bony union. The incidence of bony union was considerably higher in the group of open fracture of which wound was treated by delayed primary closure than that of the group of primary closure. 2. The incidence of primary healing of the wound in the group of delayed primary closure was remarkably higher than that of the group of primary closure of the wound. As 11 cases out of 25 cases had primary healing of the wound in the group of primary closure, whereas 21 cases out of 24 cases had primary healing of the wound in the group of delayed primary closure. 3. The mean duration of bony union in closed fracture was 19 weeks, and that of open fracture treated with primary closure of the wound was 25 weeks, whereas that in the group of delayed primary closure of the wound was 20 weeks. Bony union occurred earlier in the group of delayed primary closure than in the group of primary closure of the wound. 4. The incidence of the complications, such as infection, osteomyelitis, non union, occurred higher in the group of primary closure than that of delayed primary closure of the wound. The complications occurred remarkably higher in the group of primary osteosynthesis in open fracture of the tibia.
Rah, Jeong-Eun,Kim, Gwe-Ya,Oh, Do Hoon,Kim, Tae Hyun,Kim, Jong Won,Kim, Dae Yong,Park, Sung Yong,Shin, Dongho BioMed Central 2016 Radiation oncology Vol.11 No.-
<P><B>Background</B></P><P>The purpose of this study is to evaluate the dosimetric benefits of a proton arc technique for treating tumors of the para-aortic lymph nodes (PALN).</P><P><B>Method</B></P><P>In nine patients, a proton arc therapy (PAT) technique was compared with intensity modulated radiation therapy (IMRT) and proton beam therapy (PBT) techniques with respect to the planning target volume (PTV) and organs at risk (OAR). PTV coverage, conformity index (CI), homogeneity index (HI) and OAR doses were compared. Organ-specific radiation induced cancer risks were estimated by applying organ equivalent dose (OED) and normal tissue complication probability (NTCP).</P><P><B>Results</B></P><P>The PAT techniques showed better PTV coverage than IMRT and PBT plans. The CI obtained with PAT was 1.19 ± 0.02, which was significantly better than that for the IMRT techniques. The HI was lowest for the PAT plan and highest for IMRT. The dose to the OARs was always below the acceptable limits and comparable for all three techniques. OED results calculated based on a plateau dose–response model showed that the risk of secondary cancers in organs was much higher when IMRT or PBT were employed than when PAT was used. NTCPs of PAT to the stomach (0.29 %), small bowel (0.69 %) and liver (0.38 %) were substantially lower than those of IMRT and PBT.</P><P><B>Conclusion</B></P><P>This study demonstrates that there is a potential role for PAT as a commercialized instrument in the future to proton therapy.</P>
Tolerance design of patient‐specific range qa using the dmaic framework in proton therapy
Rah, Jeong‐,Eun,Shin, Dongho,Manger, Ryan P.,Kim, Tae Hyun,Oh, Do Hoon,Kim, Dae Yong,Kim, Gwe‐,Ya Published for the American Association of Physicis 2018 Medical physics Vol.45 No.2
<P>Conclusion: DMAIC framework can be used to provide an effective QA by setting customized tolerances. When tolerance design is customized, the quality is reasonably balanced with time and cost demands. (c) 2017 American Association of Physicists in Medicine</P>