Nonlinear mixed models for characterization of growth trajectory of New Zealand rabbits raised in tropical climate

de Sousa, Vanusa Castro,Biagiotti, Daniel,Sarmento, Jose Lindenberg Rocha,Sena, Luciano Silva,Barroso, Priscila Alves,Barjud, Sued Felipe Lacerda,de Sousa Almeida, Marisa Karen,da Silva Santos, Natana Asian Australasian Association of Animal Productio 2022 Animal Bioscience Vol.35 No.5

Objective: The identification of nonlinear mixed models that describe the growth trajectory of New Zealand rabbits was performed based on weight records and carcass measures obtained using ultrasonography. Methods: Phenotypic records of body weight (BW) and loin eye area (LEA) were collected from 66 animals raised in a didactic-productive module of cuniculture located in the southern Piaui state, Brazil. The following nonlinear models were tested considering fixed parameters: Brody, Gompertz, Logistic, Richards, Meloun 1, modified Michaelis-Menten, Santana, and von Bertalanffy. The coefficient of determination (R²), mean squared error, percentage of convergence of each model (%C), mean absolute deviation of residuals, Akaike information criterion (AIC), and Bayesian information criterion (BIC) were used to determine the best model. The model that best described the growth trajectory for each trait was also used under the context of mixed models, considering two parameters that admit biological interpretation (A and k) with random effects. Results: The von Bertalanffy model was the best fitting model for BW according to the highest value of R² (0.98) and lowest values of AIC (6,675.30) and BIC (6,691.90). For LEA, the Logistic model was the most appropriate due to the results of R² (0.52), AIC (783.90), and BIC (798.40) obtained using this model. The absolute growth rates estimated using the von Bertalanffy and Logistic models for BW and LEA were 21.51g/d and 3.16 cm², respectively. The relative growth rates at the inflection point were 0.028 for BW (von Bertalanffy) and 0.014 for LEA (Logistic). Conclusion: The von Bertalanffy and Logistic models with random effect at the asymptotic weight are recommended for analysis of ponderal and carcass growth trajectories in New Zealand rabbits. The inclusion of random effects in the asymptotic weight and maturity rate improves the quality of fit in comparison to fixed models.

Effects of solvent volatilization time on the bond strength of etch-and-rinse adhesive to dentin using conventional or deproteinization bonding techniques

de Sousa, Jose Aginaldo Junior,Carregosa Santana, Marcia Luciana,de Figueiredo, Fabricio Eneas Diniz,Faria-e-Silva, Andre Luis The Korean Academy of Conservative Dentistry 2015 Restorative Dentistry & Endodontics Vol.40 No.3

Objectives: This study determined the effect of the air-stream application time and the bonding technique on the dentin bond strength of adhesives with different solvents. Furthermore, the content and volatilization rate of the solvents contained in the adhesives were also evaluated. Materials and Methods:Three adhesive systems with different solvents (Stae, SDI, acetone; XP Bond, Dentsply De Trey, butanol; Ambar, FGM, ethanol) were evaluated. The concentrations and evaporation rates of each adhesive were measured using an analytical balance. After acid-etching and rinsing, medium occlusal dentin surfaces of human molars were kept moist (conventional) or were treated with 10% sodium hypochlorite for deproteinization. After applying adhesives over the dentin, slight air-stream was applied for 10, 30 or 60 sec. Composite cylinders were built up and submitted to shear testing. The data were submitted to ANOVA and Tukey's test (${\alpha}=0.05$). Results: Stae showed the highest solvent content and Ambar the lowest. Acetone presented the highest evaporation rate, followed by butanol. Shear bond strengths were significantly affected only by the factors of 'adhesive' and 'bonding technique' (p < 0.05), while the factor 'duration of air-stream' was not significant. Deproteinization of dentin increased the bond strength (p < 0.05). Stae showed the lowest bond strength values (p < 0.05), while no significant difference was observed between XP Bond and Ambar. Conclusions: Despite the differences in content and evaporation rate of the solvents, the duration of air-stream application did not affect the bond strength to dentin irrespective of the bonding technique.

FREEZING POINT DEPRESSION OF RAW GOAT'S MILK FROM THE REGION OF GOIÂNIA, BRAZIL

de Sousa, J.T.,Dias, M.J.,Tanezini, C.A.,D'Alessandro, W.T.,de Olineira, B.C.,de Melo Rocha, J.,dos Santos Pontes, I. Asian Australasian Association of Animal Productio 1993 Animal Bioscience Vol.6 No.4

Studies at freezing point depression (FPD) for goat milk are described in this paper. The 432 samples of raw goat milk collected in a period of two years and analysed by the use of an electronic cryoscope gave a mean value of FPD: $-0.565{\pm}0.01^{\circ}C$. Statistical significant differences were found between the morning and evening milk. The evening milk showed better quality considering the lactose and others dissolved solutes. Among the Brown, Saanen and Anglo-nubian goats, the greatest increase in FPD, occurred in the Anglo-nubian breed. The statistical analysis revealed a significant breed difference (p<0.05), when climate variation was observed. The superior and inferior values found to the FPD of the caprine milk (-0.545 to $-0.585^{\circ}C$), is important in establishing regional rules, to improve the quality control criteria and legal interpretation of standards found in the pertinent legislation. The results are also important to improve herd management so that one can increase the animal production which will affect the technological composition, and the nutritional characteristics of the resultant products.

Effect of 10% weight loss on simulated taekwondo match performance : a randomized trial

Leonardo de Sousa Fortes,Gustavo César de Vasconcelos,Bruna Daniella de Vasconcelos Costa,Pedro Pinheiro Paes,Emerson Franchini 한국운동재활학회 2017 JER Vol.13 No.6

Ultrathin Polymer Fibers Coated with an Amorphous SiO2–CaO–P2O5 Bioactive Powders for Biomedical Applications

Lilian de Siqueira,Verônica Ribeiro dos Santos,Juliani Caroline Ribeiro de Araújo,Hugo Gutemberg Patiño de Oliveira Filho,Luana Marotta Reis de Vasconcellos,Eliandra de Sousa Trichês,Alexandre Luiz So 한국섬유공학회 2023 Fibers and polymers Vol.24 No.9

The development of new biomaterials with improved properties is a trend in tissue regeneration. In this way, an innovative approach is employed in this work for obtaining polymer fibers coated with nanoparticles resulting from the simultaneous application of poly (lactic acid) (PLA)/polycaprolactone (PCL) electrospinning and bioactive particles from an amorphous multicomponent silica–calcium–phosphorus system (AMS) electrospraying. The osteogenesis was evaluated in vitro and in vivo using male rats, in which total protein, alkaline phosphatase, and biological performance through histological and histomorphometric analysis were discussed. The morphological results assessed by scanning electron microscopy showed a mesh of PLA/PCL fibers associated with AMS. The spraying of 17.44% of AMS particles in the PLA/PCL electrospun fibers decreased the Young’s modulus and tensile strength. However, the amount of AMS particles sprayed was enough to promote a reduction of 17.8% in the measured contact angle values. Phosphatase alkaline higher mean value was also observed in the fibers when in contact with the AMS, but nonstatistical difference was observed (p > 0.05). It was possible to observe the presence of mineralized nodules deposited on the bottom of the plate and between the fibers. The newly formed bone into defect filled with PLA/PCL-AMS fibers was higher than that observed in the control group. These findings suggest PLA/PCL-AMS fibers as a multifunctional composite system that may be attractive for both bone and dental tissue engineering applications.

Effects of solvent volatilization time on the bond strength of etch-and-rinse adhesive to dentin using conventional or deproteinization bonding techniques

José Aginaldo de Sousa Júnior,Márcia Luciana Carregosa Santana,Fabricio Eneas Diniz de Figueiredo,André Luis Faria-e-Silva 대한치과보존학회 2015 Restorative Dentistry & Endodontics Vol.40 No.3

Objectives: This study determined the effect of the air-stream application time and the bonding technique on the dentin bond strength of adhesives with different solvents. Furthermore, the content and volatilization rate of the solvents contained in the adhesives were also evaluated. Materials and Methods:Three adhesive systems with different solvents (Stae, SDI, acetone; XP Bond, Dentsply De Trey, butanol; Ambar, FGM, ethanol) were evaluated. The concentrations and evaporation rates of each adhesive were measured using an analytical balance. After acid-etching and rinsing, medium occlusal dentin surfaces of human molars were kept moist (conventional) or were treated with 10% sodium hypochlorite for deproteinization. After applying adhesives over the dentin, slight air-stream was applied for 10, 30 or 60 sec. Composite cylinders were built up and submitted to shear testing. The data were submitted to ANOVA and Tukey’s test (α = 0.05). Results: Stae showed the highest solvent content and Ambar the lowest. Acetone presented the highest evaporation rate, followed by butanol. Shear bond strengths were significantly affected only by the factors of ‘adhesive’ and ‘bonding technique’ (p < 0.05), while the factor ‘duration of air-stream’ was not significant. Deproteinization of dentin increased the bond strength (p < 0.05). Stae showed the lowest bond strength values (p < 0.05), while no significant difference was observed between XP Bond and Ambar. Conclusions: Despite the differences in content and evaporation rate of the solvents, the duration of air-stream application did not affect the bond strength to dentin irrespective of the bonding technique.

In vivo Antigenotoxic and Anticlastogenic Effects of Fresh and Processed Cashew (Anacardium occidentale) Apple Juices

Ana Amélia de Carvalho Melo-Cavalcante,Sandra Maria Mendes de Moura Dantas,Aracelli de Sousa Leite,Leomá Albuquerque Matos,João Marcelo de Castro e Sousa,Jaqueline Nascimento Picada,Juliana da Silva 한국식품영양과학회 2011 Journal of medicinal food Vol.14 No.7

Cashew apple juice and cajuina (processed juice) are drinks widely consumed in northeast Brazil. In vitro studies have shown that both juices have antimutagenic activity as well as antioxidant effects. These juices contain vitamins, carotenoids, and phenolic compounds. This in vivo study assessed the antigenotoxic and anticlastogenic effects of both drinks against genotoxicity and mutagenicity induced by cyclophosphamide. The comet, micronucleus, and chromosome aberrations tests were used. Male Swiss mice were divided into 6 groups (5 animals per group) and received the following by gavage, 0.15 mL/10 g body weight: group 1, water; group 2, cashew apple juice; group 3, cajuina juice; group 4, cashew apple juice and cyclophosphamide (50 mg/kg); group 5, cajuina juice and cyclophosphamide; group 6: cyclophosphamide. Both drinks significantly reduced DNA damage of peripheral blood cells (P<.001), with modulation percentages of 60.82% (cashew apple juice) and 82.19% (cajuina) when compared with the cyclophosphamide group. Cashew apple juice and cajuina modulated cyclophosphamide-induced micronucleus frequency, with up to 80.0% inhibition. Cashew apple juice and cajuina decreased the average number of cells with chromosome aberrations in bone marrow of mice by 53% and 65%, respectively. These findings demonstrate the high antigenotoxic and anticlastogenic potential of cashew apple juice and cajuina in vivo, which can be related to the antioxidant compounds found in both drinks.

Impact of Treatment Type on Overall Survival in Elderly Brazilian Women with Breast Cancer

Bello, Marcelo Adeodato,de Menezes, Raquel Ferreira,de Sousa Silva, Brunna,da Silva, Rafael de Carvalho,Cavalcanti, Rousiane Silva,da Costa Moraes, Thayane de Fatima,Tonellotto, Fabiana,de Aguiar, Suz Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.10

Objective: To analyze the survival of elderly patients with breast cancer according to the type of treatment used. Methods: A cohort study of women aged 80 or over with breast cancer registered with the Brazilian National Cancer Institute (Instituto Nacional do $C{\hat{a}}ncer$ - INCA) between 2008 and 2009 was conducted. Prognosis was analyzed according to the cancer treatment performed: surgery, radiotherapy, or hormone therapy. Analysis of the overall 5-year survival rate was performed using the Kaplan - Meier method, and comparisons of curves were undertaken using the log-rank test. For multiple regression analysis, Cox regression was used, adjusting for age and clinical stage, considering values of p < 0.05 as significant. Data were all analyzed using the statistical package SPSS version 20. Results: 70 women with a mean age of $84.0{\pm}3.7years$ at diagnosis participated in the study. The median follow-up time was 37.1 months (range 0.5-75.5), and 31 deaths (44.3%) occurred during this time. The median survival time was 51.2 months (95% CI, 44.9-57.4), higher in those who underwent surgery (p = 0.012) and those who had hormone therapy (p=0.001). Treatment with surgery reduced the risk of death by 61.7% (HR 0.3; 95% CI, 0.1-0.6; p = 0.001) when adjusted for clinical stage and age at diagnosis. However, there was no significant benefit from radiotherapy (HR 1.2; 95% CI, 0.5-2.5; p = 0.694). Conclusion: Treatment with surgery and hormone therapy increased the survival of our Brazilian patients with breast cancer aged 80 or over.

A Systems Engineering Approach for Uncertainty Analysis of a Station Blackout Scenario

de Sousa, J. Ricardo Tavares,Diab, Aya The Korean Society of Systems Engineering 2019 시스템엔지니어링학술지 Vol.15 No.1

After Fukushima Dai-ichi NPP accident, the need for implementation of diverse and flexible coping strategies (FLEX) became evident. However, to ensure the effectiveness of the safety strategy, it is essential to quantify the uncertainties associated with the station blackout (SBO) scenario as well as the operator actions. In this paper, a systems engineering approach for uncertainty analysis (UA) of a SBO scenario in advanced pressurized water reactor is performed. MARS-KS is used as a best estimate thermal-hydraulic code and is loosely-coupled with Dakota software which is employed to develop the uncertainty quantification framework. Furthermore, the systems engineering approach is adopted to identify the requirements, functions and physical architecture, and to develop the verification and validation plan. For the preliminary analysis, 13 uncertainty parameters are propagated through the model to evaluate the stability and convergence of the framework. The developed framework will ultimately be used to quantify the aleatory and epistemic uncertainties associated with an extended SBO accident scenario and assess the coping capability of APR1400 and the effectiveness of the implemented FLEX strategies.

Pharmacological Treatment of Acute Unilateral Vestibulopathy: A Review

Sousa Francisco Alves de,Alves Clara Serdoura,Pinto Ana Nóbrega,Meireles Luís,Rego Ângela Reis 대한청각학회 2024 Journal of Audiology & Otology Vol.28 No.1

There have been few investigations on the epidemiology, etiology, and medical management of acute unilateral vestibulopathy (AUV). Short-term pharmaceutical resolutions include vestibular symptomatic suppressants, anti-emetics, and some cause-based therapies. Anticholinergics, phenothiazines, antihistamines, antidopaminergics, benzodiazepines, and calcium channel antagonists are examples of vestibular suppressants. Some of these medications may show their effects through multiple mechanisms. In contrast, N-acetyl-L-leucine, Ginkgo biloba, and betahistine improve central vestibular compensation. Currently, AUV pathophysiology is poorly understood. Diverse hypotheses have previously been identified which have brought about some causal treatments presently used. According to some publications, acute administration of anti-inflammatory medications may have a deleterious impact on both post-lesional functional recovery and endogenous adaptive plasticity processes. Thus, some authors do not recommend the use of corticosteroids in AUV. Antivirals are even more contentious in the context of AUV treatment. Although vascular theories have been presented, no verified investigations employing anti-clotting or vasodilator medications have been conducted. There are no standardized treatment protocols for AUV to date, and the pharmacological treatment of AUV is still questionable. This review addresses the most current developments and controversies in AUV medical treatment.