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- 저자 : Zhuofan Liu (검색결과 2 건)
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Chen Shoucheng,Huang Zhuwei,Visalakshan Rahul Madathiparambil,Liu Haiwen,Bachhuka Akash,Wu You,Dabare Panthihage Ruvini L.,Luo Pu,Liu Runheng,Gong Zhuohong,Xiao Yin,Vasilev Krasimir,Chen Zhuofan,Chen 한국생체재료학회 2023 생체재료학회지 Vol.27 No.00
Background: Transepithelial medical devices are increasing utilized in clinical practices. However, the damage of continuous natural epithelial barrier has become a major risk factor for the failure of epithelium-penetrating implants. How to increase the “epithelial barrier structures” (focal adhesions, hemidesmosomes, etc.) becomes one key research aim in overcoming this difficulty. Directly targeting the in situ “epithelial barrier structures” related proteins (such as fibronectin) absorption and functionalization can be a promising way to enhance interface-epithelial integration. Methods: Herein, we fabricated three plasma polymerized bio-interfaces possessing controllable surface chemistry. Their capacity to adsorb and functionalize fibronectin (FN) from serum protein was compared by Liquid Chromatography- Tandem Mass Spectrometry. The underlying mechanisms were revealed by molecular dynamics simulation. The response of gingival epithelial cells regarding the formation of epithelial barrier structures was tested. Results: Plasma polymerized surfaces successfully directed distinguished protein adsorption profiles from serum protein pool, in which plasma polymerized allylamine (ppAA) surface favored adsorbing adhesion related proteins and could promote FN absorption and functionalization via electrostatic interactions and hydrogen bonds, thus subsequently activating the ITG β1-FAK-mTOR signaling and promoting gingival epithelial cells adhesion. Conclusion: This study offers an effective perspective to overcome the current dilemma of the inferior interfaceepithelial integration by in situ protein absorption and functionalization, which may advance the development of functional transepithelial biointerfaces. Graphical Abstract: Tuning the surface chemistry by plasma polymerization can control the adsorption of fibronectin and functionalize it by exposing functional protein domains. The functionalized fibronectin can bind to human gingival epithelial cell membrane integrins to activate epithelial barrier structure related signaling pathway, which eventually enhances the formation of epithelial barrier structure.
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Yi Ren,Yu Nie,Wei Ran,Zhuofan Liu,Lixia Wang,Chao Lou,Wei Chen 대한금속·재료학회 2024 METALS AND MATERIALS International Vol.30 No.2
Lattice structures with excellent mechanical performance can be achieved through delicate design. In this work, inspired bythe soft–hard multiphase crystals, three types of dual phase lattice structures (DPLS) composed of body-centered cubic withZ-struts (BCCZ) matrix phase and face and body-centered cubic with Z-struts (FBCCZ) reinforcement phase were designedand fabricated by selective laser melting (SLM) using 316L stainless steel powder. Quasi-static compression experimentand numerical simulation were carried out to investigate their mechanical properties, energy absorption and deformationbehavior. The results showed that the mechanical properties of all DPLS samples were higher than that of single phaseBCCZ lattice structure. The four-body diagonal DPLS sample exhibited the highest specific strength and specific stiffness,which was 9.0% and 14.2% higher than single phase BCCZ lattice structure; while, the two-face diagonal DPLS sample hadthe highest specific energy absorption value of 17.45 J/g. Besides, the experimental and simulated results revealed that thearrangements and volume fraction of reinforcement phase had a significant impact on the performance, deformation behaviorand internal stress distribution of the DPLS samples during compressive deformation.
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