Protective effects of vitamins C and E on dichlorodiphenyltrichloroethane-induced genotoxicity and hepatotoxicity in human liver cells

Xiao Ting Jin,Li Song,Xiang Yuan Liu,Hang Qing Li,Long Cheng,Zhuo Yu Li1,,Z. Y. Li 대한독성 유전단백체 학회 2017 Molecular & cellular toxicology Vol.13 No.2

Dichlorodiphenoxytrichloroethane (DDT), a persistent organic pollutant and hepatotoxicant, is used to control the malaria. However, scarce information exists on relevant effective inhibitors of DDT’ toxicity. The aim of this study was to investigate protective effects of natural antioxidants vitamin C (VC) or/and vitamin E (VE) on p,pʹ-DDT-induced genotoxicity and hepatotoxicity in human liver cells. p,pʹ-DDT exposure increased levels of chromatin condensation, comet parameter, micronucleus induction and DPC coefficient of HL-7702 cells in a dose-dependent manner. Also, an increase in mRNA levels of CYP1A1 as well as CYP3A4, and a decrease in UGT along with GST were observed. Interestingly, supplementation with VC or/and VE prevented p,pʹ-DDT-caused alterations in DNA damage and phase metabolism gene expressions, and the combination of VC and VE had a more protective effect than VC or VE alone. These findings illustrated that VC or/and VE could be beneficial for the alleviation of p,pʹ-DDT-incurred toxicity in human liver cells.

Effect of Sub-Structure and Precipitation Behavior on Mechanical Properties of Al–xCu–Li Alloys

Yu‑zhuo Li,Guang‑jun Zeng,Ding‑ding Lu,Zhen‑zhen Liu,San‑xi Deng,Peng‑cheng Ma,Yong‑lai Chen,Rui‑feng Zhang,Jin‑feng Li 대한금속·재료학회 2023 METALS AND MATERIALS International Vol.29 No.11

The tensile properties and microstructure of extruded and cold rolled 2A55 Al–Li alloys with different Cu content werestudied. After solution treatment, the strength of extruded sheets is slightly higher than that of cold rolled sheets due to strongdeformation texture and high density of substructure. However, the strength change order is different with the increase of Cucontent with T6-24 h. The extruded sample with higher Cu content have higher strength due to many dense T1precipitates. The δ′/θ′/δ′ composite precipitates and θ′ precipitates suppress the formation of T1precipitates, which cause cold rolled samplewith higher Cu content shows lower strength. Additionally, many fine T1precipitates nucleate at the sub-grain boundariesformed in the extrusion process, which have a significant effect on the mechanical property.

Strain-rate effects on interaction between Mode I matrix crack and inclined elliptic inclusion under dynamic loadings

Li, Ying,Qiu, Wan-Chao,Ou, Zhuo-Cheng,Duan, Zhuo-Ping,Huang, Feng-Lei Techno-Press 2012 Structural Engineering and Mechanics, An Int'l Jou Vol.44 No.6

The strain rate effects on the interaction between a Mode I matrix crack and an inclined elliptic matrix-inclusion interface under dynamic tensile loadings were investigated numerically, and the results are in agreement with previous experimental data. It is found, for a given material system, that there are the first and the second critical strain rates, by which three kinds of the subsequent crack growth patterns can be classified in turn with the increasing strain rate, namely, the crack deflection, the double crack mode and the perpendicular crack penetration. Moreover, such a crack deflection/penetration behavior is found to be dependent on the relative interfacial strength, the inclined angle and the inclusion size. In addition, it is shown that the so-called strain rate effect on the dynamic strength of granule composites can be induced directly from the structural dynamic response of materials, not be entirely an intrinsic material property.

韩国中低端化妆品进入中国市场模式的思考

Li Lian Hua(李莲,花),Li Zhuo(李卓) 대한경영교육학회 2016 경영교육저널 Vol.27 No.1

With the increase of China's national income, people has changed the idea of "beauty" and increased the demand for cosmetics, China has overtaken Japan as the world's second largest cosmetics consumer. As the "Korean wave" isescalating, coupled with the south Korean cosmetics in high technical content, good quality, reasonable price, its share in China has been rising year by year, in 2015, South Korea has surpassed Japan and the United States, became the second largest exporter of cosmetics in China only after France. On December 20th, 2015, China and South Korea free trade agreement(FTA) took effect, it will promote more and more south Korean cosmetics to enter the Chinese market. Almost sixty percent of low and middle in come earners and 37million college students in China, will form the huge mid-range cosmetics consumer groups. As China's "Internet+" and the Wechat business development, China's cosmetics market environment is changing recently. In this background, this paper aims to grasp the new change and put forward some rationalization proposals for the South Korean mid-range cosmetics entering the Chinese market step by step. 随着中国国民收入的增加, 人们对'美'的观念发生了变化, 对化妆品的需求不断增加, 中国已超越日本成长为世界第二大化妆品消费国。随着'韩流'越演越烈, 再加上韩国化妆品技术含量高、品质好, 价格合理, 其在中国的占有率逐年攀升, 2015年, 韩国已超越日本和美国, 成为仅次于法国的第二大对华化妆品出口国。2015年12月20日, 中韩自由贸易协定(FTA)的正式生效, 这将会促进越来越多的韩国化妆品进入中国市场。中国有近六成的中低收入者和3700万的在校大学生, 会形成庞大的中低端化妆品消费群体。随着中国"互联网+"和微商的发展, 目前, 中国化妆品市场销售环境在变化。在这样的背景下, 本文力争把脉新变化, 为韩国中低端化妆品更有步骤的进军中国市场提出几点合理化的建议。

Two New Phenolic Compounds from the Fruiting Bodies of Ganoderma tropicum

Li-Li Hu,Qing-Yun Ma,Sheng-Zhuo Huang,Zhi-Kai Guo,Jianchun Guo,Hao Fu Dai,You-Xing Zhao 대한화학회 2013 Bulletin of the Korean Chemical Society Vol.34 No.3

Chemical investigation of the fruiting bodies of Ganoderma tropicum led to the isolation of two new phenolic compounds, ganodermatropins A (1) and B (2). Their structures were elucidated by spectroscopic techniques (MS, 1D and 2D NMR). Ganodermatropin A exhibited antimicrobial activity against Staphylococcus aureus.

Cluster analysis of city-level carbon mitigation in South Korea

Zhuo Li(이탁) 한국컴퓨터정보학회 2023 韓國컴퓨터情報學會論文誌 Vol.28 No.7

최근 지구온난화로 인한 폭염, 태풍, 폭설 등 기후변화를 급증하고 있다. 미국 뉴욕에서 개최된 제 25차 기후변화 당사국총회(COP25)에 따른 세계 각국은 탄소중립 달성하기 위한 협상을 진행했다. 도시는 경제발전뿐만 아니라 탄소중립 과정에서도 중요한 역할을 수행한다. 본 연구는 이산화탄소와 관계되는 경제요인 및 환경요인을 고려하여 엘보우 규칙 (Elbow method) 과 K-means 군집 알고리즘을 활용하여 한국 63개 도시의 탄소배출 현황을 분석하였다. 연구결과에 따른 한국 도시는 기술집약 도시, 경공업 도시, 미래 혁신도시, 중공업 도시, 서비스 집약도시 및 농촌, 가정생산집약도시로 구분될 수 있고 향후 시도별 탄소중립 목표를 실천하기 위해 구체적인 제안을 제시하였다. The phenomenon of climate change is deteriorating which increased heatwaves, typhoons and heavy snowfalls in recent years. Followed by the 25th United nations framework convention on climate change(COP25), the world countries have achieved a consensus on achieving carbon neutrality. City plays a crucial role in achieving carbon mitigation as well as economic development. Considering economic and environmental factors, we selected 63 cities in South Korea to analyze carbon emission situation by Elbow method and K-means clustering algorithm. The results reflected that cities in South Korea can be categorized into 6 clusters, which are technology-intensive cities, light-manufacturing intensive cities, central-innovation intensive cities, heavy-manufacturing intensive cities, service-intensive cities, rural and household-intensive cities. Specific suggestions are provided to improve city-level carbon mitigation development.

The WNT/Ca2+ pathway promotes atrial natriuretic peptide secretion by activating protein kinase C/transforming growth factor-β activated kinase 1/activating transcription factor 2 signaling in isolated beating rat atria

Li Zhi-yu,Liu Ying,Han Zhuo-na,Li Xiang,Wang Yue-ying,Cui Xun,Zhang Ying 대한약리학회 2022 The Korean Journal of Physiology & Pharmacology Vol.26 No.6

WNT signaling plays an important role in cardiac development, but abnormal activity is often associated with cardiac hypertrophy, myocardial infarction, remodeling, and heart failure. The effect of WNT signaling on regulation of atrial natriuretic peptide (ANP) secretion is unclear. Therefore, the purpose of this study was to investigate the effect of Wnt agonist 1 (Wnta1) on ANP secretion and mechanical dynamics in beating rat atria. Wnta1 treatment significantly increased atrial ANP secretion and pulse pressure; these effects were blocked by U73122, an antagonist of phospholipase C. U73122 also abolished the effects of Wnta1-mediated upregulation of protein kinase C (PKC) β and γ expression, and the PKC antagonist Go 6983 eliminated Wnta1-induced secretion of ANP. In addition, Wnta1 upregulated levels of phospho-transforming growth factor-β activated kinase 1 (p-TAK1), TAK1 banding 1 (TAB1) and phospho-activating transcription factor 2 (p-ATF2); these effects were blocked by both U73122 and Go 6983. Wnta1-induced ATF2 was abrogated by inhibition of TAK1. Furthermore, Wnta1 upregulated the expression of T cell factor (TCF) 3, TCF4, and lymphoid enhancer factor 1 (LEF1), and these effects were blocked by U73122 and Go 6983. Tak1 inhibition abolished the Wnta1-induced expression of TCF3, TCF4, and LEF1 and Wnta1-mediated ANP secretion and changes in mechanical dynamics. These results suggest that Wnta1 increased the secretion of ANP and mechanical dynamics in beating rat atria by activation of PKC–TAK1–ATF2–TCF3/LEF1 and TCF4/LEF1 signaling mainly via the WNT/Ca2+ pathway. It is also suggested that WNT–ANP signaling is implicated in cardiac physiology and pathophysiology.

Effect of ZnO on the microstructures and piezoelectric properties of K0.5Na0.5NbO3 ceramics

Zhuo Li,Xiangbang Cheng,Zhonghua Yao,Yang Liu,Hanxin Liu,Minghe Cao 한양대학교 세라믹연구소 2009 Journal of Ceramic Processing Research Vol.10 No.5

Lead-free ZnO added K0.5Na0.5NbO3 piezoelectric ceramics have been prepared by a conventional solid state process. The XRD results show that all the K0.5Na0.5NbO3 ceramics with various ZnO contents are single phase with an orthorhombic perovskite structure. The bulk density obtained by the Archimedes method indicates that the addition of ZnO improves the density of K0.5Na0.5NbO3 ceramics under the same sintering conditions. Especially, at a level of 1 mol% ZnO, the sample sintered at 1100 oC for 1h exhibits the highest bulk density (ρ = 4.28 g/㎤) and shows optimal piezoelectric properties, d33 = 135 pC/N and kp = 0.40. Lead-free ZnO added K0.5Na0.5NbO3 piezoelectric ceramics have been prepared by a conventional solid state process. The XRD results show that all the K0.5Na0.5NbO3 ceramics with various ZnO contents are single phase with an orthorhombic perovskite structure. The bulk density obtained by the Archimedes method indicates that the addition of ZnO improves the density of K0.5Na0.5NbO3 ceramics under the same sintering conditions. Especially, at a level of 1 mol% ZnO, the sample sintered at 1100 oC for 1h exhibits the highest bulk density (ρ = 4.28 g/㎤) and shows optimal piezoelectric properties, d33 = 135 pC/N and kp = 0.40.

How High School Mathematics Teachers Use New Textbook : A Case Study from China

( Zhuo Li ),( Jiansheng Bao ) 한국수학교육학회 2023 수학교육연구 Vol.26 No.4

In this paper, we propose a theoretical framework for Chinese high school mathematics teachers use new textbooks based on the work of Remillard (1999) and Chau (2014). Based on this framework, a multiple case approach was used to investigate how two high school mathematics teachers from Shanghai use new textbooks. The results suggest that in the curriculum mapping arena, both the novice teacher and the expert teacher often planned to appropriate the unit content, and sometimes planned to add supplemental content. When organizing the unit content, novice teacher always planned to follow the new textbook in sequence, while expert teacher often would follow the new textbook in sequence, but sometimes planned to rearrange the unit content. In the design arena, both the novice teacher and the expert teacher tended to appropriate the introduced tasks and definitions. The novice teacher often planned to appropriate the example problems and exercise problems, while the expert teacher often intended to flexibly use the example problems and exercise problems. In the construction arena, the novice teacher seldom adjusted the planned tasks; in contrast, the expert teacher adjusted the planned tasks more frequently. In the reflection arena, the novice teacher often thought she should improve the mathematics tasks, while the expert teacher almost always thought he needed to improve the mathematics tasks. The framework shown in this paper provides a tool to investigate how mathematics teachers use textbooks.

COMPARISON OF DHA-RICH Schizochytrium ALGAL MEAL AND OIL ON GROWTH, PHYSIOLOGICAL RESPONSES AND TISSUE FATTY ACID PROFILES OF GROUPER, Epinephelus coioides

Li-Chao Zhuo,Man-Ting Chiu,Yu-Hung Lin 한국수산과학회 양식분과 2015 한국수산과학회 양식분과 학술대회 Vol.2015 No.5