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- 저자 : Zhou Pengyue (검색결과 4 건)
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Ensemble learning-based hierarchical retrieval of similar cases for site planning
Wang Pengyue,Guo Maozu,Han Yunsong,Zhao Lingling,Zhou Xiaoping,Zhang Dayu 한국CDE학회 2021 Journal of computational design and engineering Vol.8 No.6
Site planning not only involves the arrangement of a large number of elements but also considers the complexity of urban systems; hence, the design process involves large workloads and is time consuming. Retrieving similar existing cases helps architects optimize or accelerate the design process. This paper proposes a computational approach that provides valuable references by retrieving similar cases. Three types of attributes are extracted to represent a given parcel: land-use attributes, geometric attributes (area, orientation, etc.), and environmental attributes (greening rate, surrounding facilities, etc.). The complete hierarchical retrieval process is divided into three phases. The first phase selects cases whose land-use attributes are consistent with the target parcel. Then, the similarity distances between the given target parcel and the selected cases are calculated using geometric attributes. The eXtreme Gradient Boosting (XGBoost) classifier is adopted to determine which case is similar to the target parcel. Finally, similarity scores of the retrieved cases are calculated based on the environmental attributes to provide more options during the actual design. In total, 1189 cases with different land-use types in Beijing were collected for the case base. The comparative experimental results confirmed that the proposed ensemble learning-based hierarchical retrieval of similar cases approach improves the accuracy of retrieval results. Furthermore, we use a real-world target parcel to demonstrate the superiority and flexibility of the retrieval process.
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Hongli Gong,Boyan Wang,Yi Shi,Yong Shi,Xiyan Xiao,Pengyu Cao,Lei Tao,Yuezhu Wang,Liang Zhou 한국미생물학회 2017 The journal of microbiology Vol.55 No.8
The pharynx is an important site of microbiota colonization, but the bacterial populations at this site have been relatively unexplored by culture-independent approaches. The aim of this study was to characterize the microbiota structure of the pharynx. Pyrosequencing of 16S rRNA gene libraries was used to characterize the pharyngeal microbiota using swab samples from 68 subjects with laryngeal cancer and 28 subjects with vocal cord polyps. Overall, the major phylum was Firmicutes, with Streptococcus as the predominant genus in the pharyngeal communities. Nine core operational taxonomic units detected from Streptococcus, Fusobacterium, Prevotella, Granulicatella, and Veillonella accounted for 21.3% of the total sequences detected. However, there was no difference in bacterial communities in the pharynx from patients with laryngeal cancer and vocal cord polyps. The relative abundance of Firmicutes was inversely correlated with Fusobacteria, Proteobacteria, Actinobacteria, and Bacteroidetes. The correlation was evident at the genus level, and the relative abundance of Streptococcus was inversely associated with Fusobacterium, Leptotrichia, Neisseria, Actinomyces, and Prevotella. This study presented a profile for the overall structure of the microbiota in pharyngeal swab samples. Inverse correlations were found between Streptococcus and other bacterial communities, suggesting that potential antagonism may exist among pharyngeal microbiota.
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Inhibition of acetylation of histones 3 and 4 attenuates aortic valve calcification
Jia Gu,Yan Lu,Menqing Deng,Ming Qiu,Yunfan Tian,Yue Ji,Pengyu Zong,Yongfeng Shao,Rui Zheng,Bin Zhou,Xiangqing Kong,Wei Sun 생화학분자생물학회 2019 Experimental and molecular medicine Vol.51 No.-
Aortic valve calcification develops in patients with chronic kidney disease who have calcium and phosphate metabolic disorders and poor prognoses. There is no effective treatment except valve replacement. However, metabolic disorders put patients at high risk for surgery. Increased acetylation of histones 3 and 4 is present in interstitial cells from human calcific aortic valves, but whether it is involved in aortic valve calcification has not been studied. In this study, we found that treating cultured porcine aortic valve interstitial cells with a high-calcium/high-phosphate medium induced calcium deposition, apoptosis, and expression of osteogenic marker genes, producing a phenotype resembling valve calcification in vivo. These phenotypic changes were attenuated by the histone acetyltransferase inhibitor C646. C646 treatment increased the levels of class I histone deacetylase members and decreased the acetylation of histones 3 and 4 induced by the high-calcium/high-phosphate treatment. Conversely, the histone deacetylase inhibitor suberoylanilide hydroxamic acid promoted valve interstitial cell calcification. In a mouse model of aortic valve calcification induced by adenine and vitamin D treatment, the levels of acetylated histones 3 and 4 were increased in the calcified aortic valves. Treatment of the models with C646 attenuated aortic valve calcification by restoring the levels of acetylated histones 3 and 4. These observations suggest that increased acetylation of histones 3 and 4 is part of the pathogenesis of aortic valve calcification associated with calcium and phosphate metabolic disorders. Targeting acetylated histones 3 and 4 may be a potential therapy for inoperable aortic valve calcification in chronic kidney disease patients.
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Optimization of a double crystal monochromator
Jiang Zheng,Wang Eryan,Song Ruiqiang,Guo Siming,Wu Jinjie,Hou Dongjie,An Zhenghua,Zhou Pengyue 한국물리학회 2021 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.79 No.8
The double crystal diffraction structure based on Bragg diffraction is the core component of the monochromator that is widely used in synchrotron radiation beam lines and monochromatic X-ray radiation devices. The stability of monochromatic X-rays produced by using the T-structure double crystal monochromator at National Institute of Metrology was investigated experimentally. Due to its structural defects, the X-ray flux of the T-structured double crystal monochromator shows poor long-term stability. Inspired by the Channel-cut monochromator structure, we designed a new double crystal monochromator structure to improve the long-term stability of the X-ray flux. Experiments showed that the stability of the monochromatic X-ray flux for the new double crystal monochromator structure was better than 1.0%@1 h, and the energy region and flux rate of the monochromatic X-rays are significantly improved. This work provides a stable and reliable monochromatic X-ray source for the calibration of X/γ detectors such as satellite load detectors, which will contribute to the development of X/γ detection technology.
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