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Common Genetic Variations in the MUC5AC Gene are Not Related to Helicobacter pylori Serologic Status
Zhou, Cheng-Jiang,Zhang, Liu-Wei,Gao, Fang,Zhang, Bin,Wang, Ying,Chen, Da-Fang,Jia, Yan-Bin Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.24
Several lines of evidence suggest that MUC5AC genetic polymorphisms might confer susceptibility to H. pylori infection and therefore gastric cancer risk. We here assessed the association of common polymorphisms in the MUC5AC gene with H. pylori seroprevalence using an LD-based tagSNP approach in a north-western Chinese Han population. A total of 12 tagSNPs were successfully genotyped among 281 unrelated ethnic Han Chinese who had no cancer history, and no identifiable gastric disease or genetic disease. No significant association between any alleles, genotypes or haplotypes and H. pylori seroprevalence was observed. Our results suggest that common genetic variations in MUC5AC gene might not make a major contribution to the risk of H. pylori infection.
Zhou Xuefei,Miao Wei,Cheng Wenxi,Lin Haowei,Lin Haowei,Zheng Hongjuan,Cheng Qiaohuan,Wang Renjie,Yao Chenxue,Liu Xiaobo 한국화학공학회 2023 Korean Journal of Chemical Engineering Vol.40 No.6
A series of poly(arylene ether nitrile) containing versatile carboxyl and sulfonic groups (CSPEN) were magnetically functionalized by ferroferric oxide (Fe3O4), and the obtained magnetic adsorbents (Fe3O4/CSPEN) were used to remove methylene blue (MB) dye from aqueous solution. The systematical characterizations that including scanning electron microscope (SEM), X-ray powder diffractometer (XRD), X-ray photoelectron spectroscopy (XPS), vibrating sample magnetometer (VSM), Fourier transform infrared (FTIR) certified that the Fe3O4/CSPEN possessed versatile functional groups and magnetic separation properties. The batch adsorption studies revealed that the Fe3O4/CSPEN not only displayed high selective adsorption ability for cationic MB in the presence of anionic MO, but also exhibited a removal efficiency as high as 98.2%. Besides, the adsorption kinetics and isotherm matched well with pseudo-second-order model and Langmuir model, respectively, and the maximum adsorption capacity of Fe3O4/CSPEN for MB was 92.029 mg/g. The FTIR and Brunauer-Emmett-Teller (BET) analyses confirmed that the outstanding adsorption capacity of Fe3O4/CSPEN was attributed to their own microporous structure and the electrostatic interaction with MB. Therefore, the modified magnetic adsorbent can be used to selectively remove cationic dye from aqueous solution.
Cheng Zhou,Shemin Zhu,Xiuming Wu,Bo Jiang,Tao Cen,Shubao Shen 한국생물공학회 2010 Biotechnology and Bioprocess Engineering Vol.15 No.3
Penicillin acylase (PA) is known to regulate the microenvironment of nanospores. In this study, nanopores containing chemically-modified macromolecules co-assembled with immobilized PA were constructed. We also investigated the various types of functionalized mesocellular siliceous foams (MCFs) commonly used for the immobilization of PA by measuring the catalytic performance and stability of each PA preparation. Amino-MCF activated by p-benzoquinone was chosen as the optimum support for PA immobilization. Successful modification of macromolecules was verified by FT-IR and ultraviolet (UV)spectroscopy. The specific activity of PA co-assembled with dextran 10 k was 99.1 U/mg, which was 1.5-fold that of pristine immobilized PA, while the optimum pH was shifted to neutral. Compared to pristine immobilized and free PA, the optimum temperatures for the modified PA were 5 and 10oC higher, respectively. The residual activity of the ficoll derivative of PA after treatment at 50oC for 6 h was 70%, and this was later increased to 214.5% compared to that of pristine immobilized PA. The dextran 10 k derivative of PA exhibited 90.2% residual activity after 25times of continuous use. The results show that chemicallymodified macromolecules co-assembled with PA in amino-MCF provided a suitable microenvironment for enzyme stability.
Zhou, Zhong-Liu,Yin, Wen-Qing,Zou, Xiao-Peng,Huang, Dan-Ying,Zhou, Cui-Liu,Li, Lian-Mei,Chen, Ke-Cheng,Guo, Zi-Ying,Lin, San-Qing 한국응용생명화학회 2014 Applied Biological Chemistry (Appl Biol Chem) Vol.57 No.6
The extraction and solvent partition of the leaves of Eucalyptus citriodora, and repeated column chromatography for n-BuOH fraction yielded a new flavonoid glycoside, citrioside C (1), along with three known flavonoid glycosides (2-4). The latter were identified with kaempferol-3-O-${\beta}$-$\small{D}$-glucopyranosyl (12)-${\alpha}$-$\small{L}$-rhamnoside (2), kaempferol-3-O-${\alpha}$-$\small{L}$-rhamnoside (3), and quercetin-3-O-${\alpha}$-$\small{L}$-rhamnoside (4). Their chemical structures were identified on the basis of spectroscopic data analyses including NMR, MS, UV, and IR. All constitutents were isolated for the first time from the leaves of Eucalyptus citriodora. The potential antivirus activity of all the isolated compounds was evaluated. Compound 4 showed potent antiviral activity against respiratory syncytial virus with 50% inhibition concentration ($IC_{50}$) value of $1.9{\mu}g/mL$ and selective index value of 9.8.
Stability and dynamic deforming process for structureof coronary artery stents
Cheng-Ti Zhou,He-Yan Dong 한국물리학회 2005 Current Applied Physics Vol.5 No.5
Coronary stent is of a micro cylindrical net structure. In this paper stability and dynamic deforming process for structure of cor-onary artery stents in percutaneous coronary intervention (PCI) was studied by measurements of stent deformation under pressureand theoretical analysis. In PCI, a stent has two stages of loading (1) the stage stent in inated, and (2) the stage stent is left, and isunder the pressure of the shrinkage of the artery. For the rst stage, the change of the stent diameter was measured by the obser-vation with a microscope. Loaddisplacement curves of the stent in the ination process were got. The maximum deformation rateof the inating stent was 2.0 mm/s at the right end of the stent at the inating time 15.5 s. In the second stage, the buckling behaviorof the stent was studied. An ‘‘Intelligent Electronic Measurement Apparatus’’ was used for the buckling test of stents. Some newbuckling phenomena of multi-buckling were revealed in the tests. These results will be important for the research of the stentproperties..
Zhou, Liben,Cheng, Weizhong,Wang, Deng,Li, Zhaolei,Zhou, Haijun,Guo, Weijie The Korean Electrochemical Society 2022 Journal of electrochemical science and technology Vol.13 No.1
The synergistic effect of 2-chloromethylbenzimidazole (2-CBI) and potassium iodide (KI) for mild steel in 1 M hydrochloric acid solution was investigated by potentiodynamic polarization curves and electrochemical impedance spectroscopy (EIS). The results showed that, with the addition of 100 ppm potassium iodide, the inhibition efficiecy (IE) of 100 ppm 2-CBI in 1 M hydrochloric acid had been improved from 91.14% to 96.15%. And synergistic parameter of 100 ppm 2-CBI with different amounts of potassium iodide is always greater than 1. The adsorption of potassium iodide combining with 100 ppm 2-CBI obeys to the Langmuir adsorption isotherm. Thermodynamic adsorption parameters, including ∆G<sup>0</sup><sub>ads</sub>, ∆H<sub>a</sub> and ∆S<sub>a</sub> of the adsorption of the combinned inhibitor, as well as the E<sub>a</sub> of the mild steel corrosion in 1 M HCl with the combinned inhibitor, were calculated.
Cheng Zhou,Shubao Shen,Bo Jiang,Zecui Sheng,Shemin Zhu 한국화학공학회 2011 Korean Journal of Chemical Engineering Vol.28 No.3
Chemically modified macromolecules were assembled with adsorptive trypsin in mesoporous silica foams (MCFs) to establish covalent linkage. Effects of catalytic properties and stability of immobilized trypsin were examined. The addition of chemically modified protein (BSA) and polysaccharide (ficoll) to the immobilized trypsin exhibited high coupled yield (above 90%) and relative activities (174.5% and 175.9%, respectively), showing no protein leaching after incubating for 10 h in buffers. They showed broader pH and temperature profiles, while the half life of thermal stability of BSA-modified preparation at 50 ℃ increased to 1.3 and 2.3 times of unmodified and free trypsin,respectively. The modified trypsin in aqueous-organic solvents exhibited 100% activity after 6 h at 50 ℃. The kinetic parameters of trypsin preparations and suitable pore diameter of MCFs warranted compatibility of covalent modification for substrate transmission. The covalent crowding modification for immobilized trypsin in nanopores establishes suitable and accessible microenvironment and renders possibility of biological application.
Zhou Weiwei,Hou Shuai,Deng Shu,Peng Yang,Fu Wei,Zhou Yang,Yang Jie,Peng Cheng 한국조직공학과 재생의학회 2023 조직공학과 재생의학 Vol.20 No.3
BACKGROUND: Hyaluronic acid dermal fillers are composed of cross-linked viscoelastic particles with high biocompatibility. The performance of the fillers is determined by the viscoelastic properties of particles and the connecting force between particles. However, the relationships among the properties of fillers, the interaction of the gels and the surrounding tissue are not clear enough. METHOD: Four kinds of typical dermal filler were selected in this research to reveal the interaction between the gels and cells. A series of analytical tools was applied to characterize the structure and physicochemical properties of the gel, as well as observing their interaction with the surrounding tissues in vivo and discussing their internal mechanism. RESULT: The large particles internal the gel and the high rheological properties endow the Restylane2 with excellent support. However, these large-size particles have a significant impact on the metabolism of the local tissue surrounding the gel. Juve´derm3 present gel integrity with the high cohesiveness and superior support. The rational matching of large and small particles provides the Juve´derm3 with supporting capacity and excellent biological performance. Ifresh is characterized by small-size particles, moderate cohesiveness, good integrity, lower viscoelasticity and the superior cellular activity located the surrounding tissues. Cryohyaluron has high cohesion and medium particle size and it is prominent in cell behaviors involving localized tissues. Specific macroporous structure in the gel may facilitate the nutrients delivering and removing the waste. CONCLUSION: It’s necessary to make the filler both sufficient support and biocompatibility through the rational matching of particle sizes and rheological properties. Gels with macroporous structured particle showed an advantage in this area by providing a space inside the particle.
Cheng Zhou,Shubao Shen,Xiumin Wu,Bo Jiang 한국화학공학회 2011 Korean Journal of Chemical Engineering Vol.28 No.12
Immobilized trypsin in mesoporous silica foams was used to catalyze dipeptide synthesis in hydrophilic organic solvent instead of soluble form. The area surface of nano support was measured. The catalytic activity, coupled yield and kinetic characterization of immobilized trypsin were examined. Bz-Arg-OEt was chosen as the acyl donor with Lys-OH as the nucleophile. The trypsin-catalyzed synthesis condition was optimized, such as catalytic temperature,pH, reaction time, physical properties and content of organic solvents, together with the added enzyme amount. The immobilized trypsin showed 112.8% of residual activity with 91.9% of coupled yield, and the kinetic parameters exhibited accessibility for transmission. The product yield of 5.8% was reached at the optimum conditions for enzymatic synthesis of dipeptide: 800 mg of wet immobilized trypsin (200 mg/g support) was used in Tris-HCl buffer (0.1 mol/L, pH 8.0) containing 80% (v/v) ethanol solvents for 6 h of reaction time at 35 oC. This attempt of immobilized strategy for trypsin in nanopores renders the possibility of wide application of inorganic nano-sized support in catalytic synthesis process, which can avoid usage of large amounts of organic solvents in washing steps by chemical methods and reduce the tedious purification process of its soluble form.