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- 저자 : Zhongnan Zhang (검색결과 2 건)
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Yuanyuan Chen,Zhongnan Li,Xue Bai,Yanmin Feng,Lin Feng,Deyuan Zhang,Huawei Chen,Haosheng Chen 한국바이오칩학회 2021 BioChip Journal Vol.15 No.1
Because of the rapid development of precision medicine, single-cell analysis has attracted increasing research attention, especially for erythrocyte, whose potential role in the formation of vascular plaque (atherosclerosis) has emphasized the importance of flow characteristics of single erythrocytes in bionic microfluidics. Based on the high incidence of vascular plaques among the elderly and those who have received blood transfusions, we hypothesized that cell membrane hardening changes the fluid adaptability of individual erythrocytes. This hypothesis was verified using an in vitro microfluidic technique based on an analysis of the flow morphology and cell trajectory of individual cells. A symmetrical microchannel was fabricated with a central stenosis to simulate a blood vessel containing plaque. During flowing through this microchannel, normal erythrocyte predominantly exhibited deforming, rotating, and lifting morphologies, resulting in discontinuous contact with the channel wall and a narrower distribution. Conversely, hardened erythrocytes exhibited rolling, swinging, and tumbling morphologies, resulting in stable and continuous contact with the channel wall and a wider distribution. These results indicate that cell membrane hardening decrease cell fluid adaptability on a microscopic scale. This research can offer some new insights into vascular plaques research from a bio-tribological and mechanical perspectives.
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Jingyuan Cao,Fei Wang,Shuai Liang,Xue Tong,Zhongnan Zhang,Jian Feng,Haifeng Wang,Xingmao Jiang 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2017 NANO Vol.12 No.10
Nickel nanoparticles embedded in mesoporous silica (Ni/SiO2) were successfully synthesized by microwave-assisted in situ self-assembly method using colloidal silica, urea and nickel nitrate as precursors and glucose as carbon template, which resulted in mesoporous structure of silica through removal of template. Ni nanoparticles were uniformly well-dispersed within mesoporous silica, which were 3.5–4.0nm in diameter and had a very narrow particle size distribution. In addition, particle size of Ni nanoparticles can be controllably adjusted by microwave power. As prepared Ni/SiO2 catalyst exhibited better catalytic activity for reduction of 4-nitrophenol (4-NP) to 4-aminophenol (4-AP) than Ni/SiO2-IM catalyst, which was mainly attributed to confinement effect of mesoporous silica support. This simple and versatile method can also be extended to cover many kinds of other supported catalysts for broad applications in many other catalytic reactions in the future.
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